Objective
Aging drives cognitive impairment and general health demise increasing the susceptibility to neurodegenerative disorders in healthy individuals. It is also associated with changes in the gut-microbiota and a general increase in the secretion of stress hormones, known to have debilitating effects when sustained. The gut-microbiota has recently emerged has a crucial modulator of cognitive abilities and general health. Nonetheless, the causes and consequences of the gut-microbiota changes seen in aging are currently unknown. In this application, we propose to study the importance of the age-associated gut-microbiota changes on brain functions, by swapping the gut-microbiota from aged mice into young mice and vice-versa. This will allow knowing the contribution of the gut-microbiota in the cognitive decline and depressive state associated with aging. Furthermore, we will test if the increase in stress hormones known to occur during aging are upstream of those age-associated microbiota changes, by testing the involvement of the amygdala to the hypothalamus-adrenal axis in this phenomena. This will be achieved by using a chemo-genetic approach to control the activation of each component of this pathway. This project will provide the first description of the functional repercussions of the age-associated changes in the gut-microbiota composition on learning and memory deficits and depression, and possibly elucidate one of the upstream mechanisms responsible. The outcome of this work will pave the way toward the elaboration of probiotic treatments against the detrimental effect of aging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.