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Vision and Navigation in Mouse Cortex

Objective

One of the main functions of the visual system is to help the animal navigate through its environment, and one of the main ways that animals navigate is by using visual landmarks. Visually-guided navigation requires a change of coordinates from an eye-centered to a world-centered representation of the external environment. We know much about the two ends of this transformation, i.e. about the visual selectivity of neurons in Primary visual cortex and the place selectivity of place cells in hippocampus CA1. However, little is known about how this transition happens along the way. The recent development of virtual reality environment might help filling this gap: mice can navigate through an artificial environment while their head is fixed, therefore enabling a careful monitoring of the animal behavior, accurate control of the displayed visual inputs and the stability of the recording. In this project, we propose to investigate the transition from an eye-centered to a world-centered representation across the successive visual areas of the mouse cortex. Using a combination of electrophysiological and imaging techniques, we will record simultaneously in hippocampus CA1 and in different visual cortical areas while head-fixed mice navigate through a virtual maze to get a reward at specific locations. We will also take advantage of the virtual reality setup to modify visual cues and navigational cues such as to estimate the nature of the modulation of visually driven responses by navigational information. This approach will help understand how visual processing in cortical areas is modulated by the animal’s position in the environment. We believe that it will also set the foundations for a new field of research that investigates the function of the visual cortex as part of the navigation system rather than a simple feature analyzer of the visual scene.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2015

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Coordinator

UNIVERSITY COLLEGE LONDON
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 195 454,80
Address
GOWER STREET
WC1E 6BT LONDON
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 195 454,80
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