Objective
Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity. The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesis. Furthermore, to increase biomass production and maintain redox homeostasis, ECs shunt glycolytic intermediates into glycolysis side-pathways. Further ECs diverge from pre-existing blood vessel into avascular tissue, the scarcer external glucose levels will become. Currently, how ECs maintain the generation of glycolytic intermediates under such conditions remains unknown. One possibility is the de-novo synthesis of these intermediates through gluconeogenesis (GNG).
To date, nothing is known about GNG metabolism in ECs, which underscores the novelty of my proposal. GNG is particularly interesting since preliminary findings indicate that ECs express all enzymes involved in GNG, and impairing this pathway decreases EC proliferation and sprouting. Therefore, through a multi-angled approach, I will unravel the role of GNG in ECs and uncover its contribution to blood vessel sprouting both in normal and pathological angiogenesis.
Ultimately this project will explore whether blocking GNG may inhibit pathological angiogenesis (e.g. cancer) and translate my findings into therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell metabolism
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.