Periodic Reporting for period 1 - miRCaP (Innovative nanoparticle formulation for a miR-133 based treatment of cardiac hypertrophy)
Période du rapport: 2016-12-01 au 2018-05-31
The answer to this problem consisted here in the evaluation of an unconventional strategy for the non-invasive and nanoparticle-based delivery of therapeutic miR-133 mimics to the diseased heart. In the first part of the project, calcium phosphate-based nanoparticles (CaPs) loaded with miR mimics were generated and assessed for quality and stability. Then, activities were dedicated to the evaluation of miR-CaP biocompatibility and delivery of miR mimics to the heart. Subsequently, the research plan continued with assessment of delivery of miR-133 mimic to diseased heart and evaluation of the therapeutic effect.