Chemistry and Biology in Synergy - Studies of hydrogenases using a combination of synthetic chemistry and biological tools

Project Information

CaBiS

Grant agreement ID: 714102

DOI

10.3030/714102

Project closed

EC signature date 14 November 2016

Start date 1 February 2017

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 494 880,00

EU contribution

€ 1 494 880,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

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Publications

Peer reviewed articles (13)

The reactivity of molecular oxygen and reactive oxygen species with [FeFe] hydrogenase biomimetics: reversibility and the role of the second coordination sphere

Author(s): Vincent C.-C. Wang, Charlène Esmieu, Holly J. Redman, Gustav Berggren, Leif Hammarström
Published in: Dalton Transactions, Issue 49/3, 2020, Page(s) 858-865, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9dt04618f

[FeFe]-hydrogenase maturation : H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy

Author(s): Brigitta Németh; Moritz Senger; Holly J. Redman; Pierre Ceccaldi; Joan B. Broderick; Ann Magnuson; Sven T. Stripp; Michael Haumann; Gustav Berggren
Published in: Journal of Biological Inorganic Chemistry, Issue 1, 2020, ISSN 1432-1327
Publisher: Springer Nature
DOI: 10.26434/chemrxiv.12168303

Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture

Author(s): Henrik Land, Alina Sekretareva, Ping Huang, Holly J. Redman, Brigitta Németh, Nakia Polidori, Lívia S. Mészáros, Moritz Senger, Sven T. Stripp, Gustav Berggren
Published in: Chemical Science, Issue 11/47, 2020, Page(s) 12789-12801, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc03319g

The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions

Author(s): Brigitta Németh, Henrik Land, Ann Magnuson, Anders Hofer, Gustav Berggren
Published in: Journal of Biological Chemistry, Issue 295/33, 2020, Page(s) 11891-11901, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011419

From protein engineering to artificial enzymes – biological and biomimetic approaches towards sustainable hydrogen production

Author(s): C. Esmieu, P. Raleiras, G. Berggren
Published in: Sustainable Energy & Fuels, Issue 2/4, 2018, Page(s) 724-750, ISSN 2398-4902
Publisher: The Royal Society of Chemistry
DOI: 10.1039/C7SE00582B

In vivo activation of an [FeFe] hydrogenase using synthetic cofactors

Author(s): N. Khanna, C. Esmieu, L. S. Mészáros, P. Lindblad, G. Berggren
Published in: Energy & Environmental Science, Issue 10/7, 2017, Page(s) 1563-1567, ISSN 1754-5692
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7EE00135E

In Vivo EPR Characterization of Semi-Synthetic [FeFe] Hydrogenases

Author(s): Lívia S. Mészáros, Brigitta Németh, Charlène Esmieu, Pierre Ceccaldi, Gustav Berggren
Published in: Angewandte Chemie International Edition, Issue 57/10, 2018, Page(s) 2596-2599, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201710740

Generation of a functional, semisynthetic [FeFe]-hydrogenase in a photosynthetic microorganism

Author(s): Adam Wegelius, Namita Khanna, Charlène Esmieu, Giovanni Davide Barone, Filipe Pinto, Paula Tamagnini, Gustav Berggren, Peter Lindblad
Published in: Energy & Environmental Science, Issue 11/11, 2018, Page(s) 3163-3167, ISSN 1754-5692
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ee01975d

Monitoring H-cluster assembly using a semi-synthetic HydF protein

Author(s): Brigitta Németh, Charlène Esmieu, Holly J. Redman, Gustav Berggren
Published in: Dalton Transactions, Issue 48/18, 2019, Page(s) 5978-5986, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8dt04294b

Synthesis of a miniaturized [FeFe] hydrogenase model system

Author(s): Charlène Esmieu, Meiyuan Guo, Holly J. Redman, Marcus Lundberg, Gustav Berggren
Published in: Dalton Transactions, Issue 48/7, 2019, Page(s) 2280-2284, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8dt05085f

Spectroscopic investigations under whole cell conditions provide new insight into the metal hydride chemistry of [FeFe]-hydrogenase

Author(s): Lívia Mészáros, Pierre Ceccaldi, Marco Lorenzi, Holly Jayne Redman, Emanuel Pfitzner, Joachim Heberle, Moritz Senger, Sven Timo Stripp, Gustav Berggren
Published in: Chemical Science, 2020, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc00512f

Discovery of novel [FeFe]-hydrogenases for biocatalytic H 2 -production

Author(s): Henrik Land, Pierre Ceccaldi, Lívia S. Mészáros, Marco Lorenzi, Holly J. Redman, Moritz Senger, Sven T. Stripp, Gustav Berggren
Published in: Chemical Science, Issue 10/43, 2019, Page(s) 9941-9948, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc03717a

Semi-synthetic hydrogenases—in vitro and in vivo applications

Author(s): Lívia S. Mészáros; Henrik Land; Holly J. Redman; Gustav Berggren
Published in: Current Opinion in Green and Sustainable Chemistry, 2021, ISSN 2452-2236
Publisher: Elsevier
DOI: 10.1016/j.cogsc.2021.100521