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Rheumatoid Arthritis Caught Early: investigating biological mechanisms preceding chronification of joint inflammation to identify patients prior to presentation of classic chronic arthritis

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Publications

Intermetatarsal bursitis, a novel feature of juxta-articular inflammation in early rheumatoid arthritis that is related to clinical signs: results of a longitudinal MRI-study

Author(s): Bastiaan T van Dijk, Yousra J Dakkak, Xanthe M E Matthijssen, Ellis Niemantsverdriet, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: Arthritis Care Res (Hoboken), 2021, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.24640

Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

Author(s): Ellis Niemantsverdriet, Erik B. van den Akker, Debbie M. Boeters, Susan J. F. van den Eeden, Annemieke Geluk, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02361-2

Walking disabilities are associated with tenosynovitis at the metatarsophalangeal joints: A longitudinal MRI‐study in early arthritis

Author(s): Yousra J. Dakkak, Fenne Wouters, Xanthe M.E. Matthijssen, Monique Reijnierse, Annette H.M. van der Helm‐van Mil
Published in: Arthritis Care & Research, 2020, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.24452

Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways

Author(s): Matthijssen XME, Niemantsverdriet E, Le Cessie S, van der Helm-van Mil AHM
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa658

Do autoantibody-responses mature between presentation with arthralgia suspicious for progression to rheumatoid arthritis and development of clinically apparent inflammatory arthritis? A longitudinal serological study.

Author(s): Fenne Wouters; Ellis Niemantsverdriet; Nazike Salioska; Annemarie L. Dorjée; René E. M. Toes; Annette H M van der Helm-van Mil; Annette H M van der Helm-van Mil
Published in: Ann Rheum Dis, 2020, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218221

Not only synovitis but also tenosynovitis needs to be considered: why it is time to update textbook images of rheumatoid arthritis

Author(s): Rogier C, Hayer S, van der Helm-van Mil AHM
Published in: Annals of the Rheumatic Diseases, 2019, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216350

DMARD-free remission as novel treatment target in rheumatoid arthritis: A systematic literature review of achievability and sustainability

Author(s): M Verstappen, E van Mulligen, P H P de Jong, A H M van der Helm-Van Mil
Published in: RMD Open, 6/1, 2020, Page(s) e001220, ISSN 2056-5933
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2020-001220

Morning stiffness precedes the development of RA and associates with systemic and subclinical joint inflammation in arthralgia patients

Author(s): Doortje I. Krijbolder, Fenne Wouters, Elise van Mulligen, Annette H.M. van der Helm-van Mil
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab651

Work participation is reduced during the development of RA, months before clinical arthritis manifests

Author(s): Rogier C, de Jong PHP, van der Helm-van Mil AHM, van Mulligen E
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab793

Do magnetic resonance imaging-detected erosions predict progression to rheumatoid arthritis in patients presenting with clinically suspect arthralgia? A longitudinal study

Author(s): F Wouters, XME Matthijssen, DM Boeters, RM Ten Brinck, AHM Van Der Helm-Van Mil, E Niemantsverdriet
Published in: Scandinavian Journal of Rheumatology, 49/6, 2020, Page(s) 461-467, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2020.1737221

Referring early arthritis patients within 6 weeks versus 12 weeks after symptom onset: an observational cohort study

Author(s): Ellis Niemantsverdriet, Maxime Dougados, Bernard Combe, Annette H M van der Helm-van Mil
Published in: The Lancet Rheumatology, 2/6, 2020, Page(s) e332-e338, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(20)30061-8

Subclinical synovitis in arthralgia: how often does it result in clinical arthritis? Reflecting on starting points for disease-modifying anti-rheumatic drug treatment

Author(s): Rogier C, Wouters F, van Boheemen L, van Schaardenburg D, de Jong PHP, van der Helm-van Mil AHM
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa774

Realising early recognition of arthritis in times of increased telemedicine: the value of patient-reported swollen joints

Author(s): Rogier C, van Dijk BT, Brouwer E, de Jong PHP, van der Helm-van Mil AHM
Published in: Annals of the Rheumatic Diseases, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219513

Undifferentiated arthritis; a changing population who did not benefit from enhanced DMARD-strategies – results from a 25-years longitudinal inception cohort

Author(s): M. Verstappen, X.M.E. Matthijssen, A.H.M. van der Helm-van Mil
Published in: Rheumatology (Oxford), 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab880

Tenosynovitis has a high sensitivity for early ACPA-positive and ACPA-negative RA: a large cross-sectional MRI study

Author(s): Matthijssen XME, Wouters F, Sidhu N, Niemantsverdriet E, van der Helm-van Mil A.
Published in: Ann Rheum Dis, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219302

During development of rheumatoid arthritis, intermetatarsal bursitis may occur before clinical joint swelling: a large imaging study in patients with clinically suspect arthralgia

Author(s): Bastiaan T van Dijk, Fenne Wouters, Elise van Mulligen, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab830

The value of inquiring about functional impairments for early identification of inflammatory arthritis: a large cross-sectional derivation and validation study from the Netherlands

Author(s): Bastiaan van Dijk, Hanna W van Steenbergen, Ellis Niemantsverdriet, Elisabeth Brouwer, Annette van der Helm-van Mil
Published in: BMJ Open, 10/12, 2020, Page(s) e040148, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-040148

Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis

Author(s): M. Verstappen, E. Niemantsverdriet, X. M. E. Matthijssen, S. le Cessie, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02368-9

Preventing progression from arthralgia to arthritis: targeting the right patients

Author(s): Hanna W. van Steenbergen, José A. Pereira da Silva, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil
Published in: Nature Reviews Rheumatology, 14/1, 2017, Page(s) 32-41, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/nrrheum.2017.185

The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it of additional benefit?

Author(s): Aleid C Boer, Debbie M Boeters, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2018-213143, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213143

Sequence of joint tissue inflammation during rheumatoid arthritis development

Author(s): R. M. ten Brinck, H. W. van Steenbergen, A. H. M. van der Helm–van Mil
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1756-z

Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

Author(s): Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1587-y

Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis

Author(s): Debbie M Boeters, Aleid C Boer, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 78/1, 2018, Page(s) 144-146, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213851

Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study

Author(s): Leonie E Burgers, Robin M ten Brinck, Annette H M van der Helm-van Mil
Published in: Rheumatology, 58/1, 2018, Page(s) 86-93, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/key220

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia

Author(s): Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1824-z

Which patients presenting with arthralgia eventually develop rheumatoid arthritis? The current state of the art

Author(s): Debbie M Boeters, Karim Raza, Annette H M vander Helm-van Mil
Published in: RMD Open, 3/2, 2017, Page(s) e000479, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2017-000479

Are MRI-detected erosions specific for RA? A large explorative cross-sectional study

Author(s): Debbie M Boeters, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Robert B M Landewé, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2017-212252, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212252

Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review

Author(s): Yousra J Dakkak, Désirée M van der Heijde, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: RMD Open, 4/2, 2018, Page(s) e000796, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000796

Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example

Author(s): Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1591-2

Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis

Author(s): Aleid C Boer, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 78/1, 2018, Page(s) e1-e1, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212867

Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study

Author(s): L. E. Burgers, D. M. Boeters, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1553-8

Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar

Author(s): Aleid C. Boer, Annelies Boonen, Annette H. M. van der Helm van Mil
Published in: Arthritis Care & Research, 70/7, 2018, Page(s) 987-996, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.23497

Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis

Author(s): Robin M ten Brinck, Hanna W van Steenbergen, Annette H M van der Helm-van Mil
Published in: RMD Open, 4/2, 2018, Page(s) e000748, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000748

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

Author(s): Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1845-7

Difficulties making a fist in clinically suspect arthralgia: an easy applicable phenomenon predictive for RA that is related to flexor tenosynovitis

Author(s): Fenne Wouters, Florus J van der Giesen, Xanthe M E Matthijssen, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 78/10, 2019, Page(s) 1438-1439, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215402

Contribution of tenosynovitis of small joints to the symptom morning stiffness in patients presenting with undifferentiated and rheumatoid arthritis

Author(s): AC Boer, DM Boeters, E Niemantsverdriet, AHM van der Helm-van Mil
Published in: Scandinavian Journal of Rheumatology, 2020, Page(s) 1-5, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2019.1696404

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia

Author(s): Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-2002-z

Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care

Author(s): L. E. Burgers, J. A. van der Pol, T. W. J. Huizinga, C. F. Allaart, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1893-z

Rheumatoid Arthritis and Tenosynovitis at the Metatarsophalangeal Joints: An Anatomic and MRI Study of the Forefoot Tendon Sheaths

Author(s): Yousra J. Dakkak, Friso P. Jansen, Marco C. DeRuiter, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Radiology, 295/1, 2020, Page(s) 146-154, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.2020191725

Reliability of Magnetic Resonance Imaging (MRI) Scoring of the Metatarsophalangeal Joints of the Foot according to the Rheumatoid Arthritis MRI Score

Author(s): Yousra J. Dakkak, Xanthe M.E. Matthijssen, Désirée van der Heijde, Monique Reijnierse, Annette H. van der Helm-van Mil
Published in: The Journal of Rheumatology, 2019, Page(s) jrheum.190258, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.190258

Improving the feasibility of MRI in clinically suspect arthralgia for prediction of rheumatoid arthritis by omitting scanning of the feet

Author(s): Aleid C Boer, Fenne Wouters, Yousra J Dakkak, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez436

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA

Author(s): Xanthe ME Matthijssen, Tom WJ Huizinga, Ellis Niemantsverdriet, Annette HM van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-215843, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215843

ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

Author(s): Debbie M. Boeters, Leonie E. Burgers, Eric H. Sasso, Tom W. J. Huizinga, Annette H. M. van der Helm – van Mil
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1902-2

Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis

Author(s): Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-2102-9

Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status

Author(s): Debbie M Boeters, Leonie E Burgers, René EM Toes, Annette van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 78/11, 2019, Page(s) 1497-1504, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214868

Window of opportunity in rheumatoid arthritis – definitions and supporting evidence: from old to new perspectives

Author(s): Leonie E Burgers, Karim Raza, Annette H van der Helm - van Mil
Published in: RMD Open, 5/1, 2019, Page(s) e000870, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000870

The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis

Author(s): Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02162-7

The value of the squeeze test for detection of subclinical synovitis in patients with arthralgia suspicious for progression to RA

Author(s): Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa082

MRI detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis

Author(s): Navkiran Sidhu, Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology (Oxford), 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab515

Is shoulder involvement in clinically suspect arthralgia an early feature of rheumatoid arthritis? A longitudinal ultrasound study

Author(s): Rogier C, van der Ven M, van der Helm-van Mil AHM, de Jong PHP
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa052

Increased frequency of intermetatarsal and submetatarsal bursitis in early rheumatoid arthritis: a large case-controlled MRI study

Author(s): Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil, Monique Reijnierse
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02359-w

Unraveling heterogeneity within ACPA-negative rheumatoid arthritis; the subgroup of patients with a strong clinical and serological response to initiation of DMARD-treatment favor disease resolution

Author(s): M. Verstappen, H.W. van Steenbergen, P.H.P. de Jong, A.H.M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 2022, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02671-z

Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population

Author(s): Xanthe M E Matthijssen, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2020, Page(s) annrheumdis-2020-217609, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-217609

Comparison between 1.5T and 3.0T MRI: both field strengths sensitively detect subclinical inflammation of hand and forefoot in patients with arthralgia

Author(s): Doortje I. Krijbolder, Marloes Verstappen, Fenne Wouters, Leroy R. Lard, Petronella DM de Buck, Josien J.Veris-van Dieren, Johannes L. Bloem, Monique Reijnierse, Annette H.M. van der Helm-van Mil
Published in: Scandinavian Journal of Rheumatology, 2021, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2021.1935313

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands

Author(s): Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Tom W. J. Huizinga, Annette H. M. van der Helm–van Mil
Published in: PLOS Medicine, 17/9, 2020, Page(s) e1003296, ISSN 1549-1676
Publisher: PLOS
DOI: 10.1371/journal.pmed.1003296