Rheumatoid Arthritis Caught Early: investigating biological mechanisms preceding chronification of joint inflammation to identify patients prior to presentation of classic chronic arthritis

Publications

Peer reviewed articles (40)

Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

Author(s): Ellis Niemantsverdriet, Erik B. van den Akker, Debbie M. Boeters, Susan J. F. van den Eeden, Annemieke Geluk, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-02361-2

Walking disabilities are associated with tenosynovitis at the metatarsophalangeal joints: A longitudinal MRI‐study in early arthritis

Author(s): Yousra J. Dakkak, Fenne Wouters, Xanthe M.E. Matthijssen, Monique Reijnierse, Annette H.M. van der Helm‐van Mil
Published in: Arthritis Care & Research, 2020, ISSN 2151-464X
DOI: 10.1002/acr.24452

DMARD-free remission as novel treatment target in rheumatoid arthritis: A systematic literature review of achievability and sustainability

Author(s): M Verstappen, E van Mulligen, P H P de Jong, A H M van der Helm-Van Mil
Published in: RMD Open, Issue 6/1, 2020, Page(s) e001220, ISSN 2056-5933
DOI: 10.1136/rmdopen-2020-001220

Do magnetic resonance imaging-detected erosions predict progression to rheumatoid arthritis in patients presenting with clinically suspect arthralgia? A longitudinal study

Author(s): F Wouters, XME Matthijssen, DM Boeters, RM Ten Brinck, AHM Van Der Helm-Van Mil, E Niemantsverdriet
Published in: Scandinavian Journal of Rheumatology, Issue 49/6, 2020, Page(s) 461-467, ISSN 0300-9742
DOI: 10.1080/03009742.2020.1737221

Referring early arthritis patients within 6 weeks versus 12 weeks after symptom onset: an observational cohort study

Author(s): Ellis Niemantsverdriet, Maxime Dougados, Bernard Combe, Annette H M van der Helm-van Mil
Published in: The Lancet Rheumatology, Issue 2/6, 2020, Page(s) e332-e338, ISSN 2665-9913
DOI: 10.1016/s2665-9913(20)30061-8

The value of inquiring about functional impairments for early identification of inflammatory arthritis: a large cross-sectional derivation and validation study from the Netherlands

Author(s): Bastiaan van Dijk, Hanna W van Steenbergen, Ellis Niemantsverdriet, Elisabeth Brouwer, Annette van der Helm-van Mil
Published in: BMJ Open, Issue 10/12, 2020, Page(s) e040148, ISSN 2044-6055
DOI: 10.1136/bmjopen-2020-040148

Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis

Author(s): M. Verstappen, E. Niemantsverdriet, X. M. E. Matthijssen, S. le Cessie, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-02368-9

Preventing progression from arthralgia to arthritis: targeting the right patients

Author(s): Hanna W. van Steenbergen, José A. Pereira da Silva, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil
Published in: Nature Reviews Rheumatology, Issue 14/1, 2017, Page(s) 32-41, ISSN 1759-4790
DOI: 10.1038/nrrheum.2017.185

The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it of additional benefit?

Author(s): Aleid C Boer, Debbie M Boeters, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2018-213143, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2018-213143

Sequence of joint tissue inflammation during rheumatoid arthritis development

Author(s): R. M. ten Brinck, H. W. van Steenbergen, A. H. M. van der Helm–van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
DOI: 10.1186/s13075-018-1756-z

Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

Author(s): Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
DOI: 10.1186/s13075-018-1587-y

Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis

Author(s): Debbie M Boeters, Aleid C Boer, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/1, 2018, Page(s) 144-146, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2018-213851

Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study

Author(s): Leonie E Burgers, Robin M ten Brinck, Annette H M van der Helm-van Mil
Published in: Rheumatology, Issue 58/1, 2018, Page(s) 86-93, ISSN 1462-0324
DOI: 10.1093/rheumatology/key220

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia

Author(s): Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-1824-z

Which patients presenting with arthralgia eventually develop rheumatoid arthritis? The current state of the art

Author(s): Debbie M Boeters, Karim Raza, Annette H M vander Helm-van Mil
Published in: RMD Open, Issue 3/2, 2017, Page(s) e000479, ISSN 2056-5933
DOI: 10.1136/rmdopen-2017-000479

Are MRI-detected erosions specific for RA? A large explorative cross-sectional study

Author(s): Debbie M Boeters, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Robert B M Landewé, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2017-212252, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2017-212252

Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review

Author(s): Yousra J Dakkak, Désirée M van der Heijde, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: RMD Open, Issue 4/2, 2018, Page(s) e000796, ISSN 2056-5933
DOI: 10.1136/rmdopen-2018-000796

Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example

Author(s): Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
DOI: 10.1186/s13075-018-1591-2

Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis

Author(s): Aleid C Boer, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/1, 2018, Page(s) e1-e1, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2017-212867

Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study

Author(s): L. E. Burgers, D. M. Boeters, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
DOI: 10.1186/s13075-018-1553-8

Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar

Author(s): Aleid C. Boer, Annelies Boonen, Annette H. M. van der Helm van Mil
Published in: Arthritis Care & Research, Issue 70/7, 2018, Page(s) 987-996, ISSN 2151-464X
DOI: 10.1002/acr.23497

Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis

Author(s): Robin M ten Brinck, Hanna W van Steenbergen, Annette H M van der Helm-van Mil
Published in: RMD Open, Issue 4/2, 2018, Page(s) e000748, ISSN 2056-5933
DOI: 10.1136/rmdopen-2018-000748

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

Author(s): Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-1845-7

Difficulties making a fist in clinically suspect arthralgia: an easy applicable phenomenon predictive for RA that is related to flexor tenosynovitis

Author(s): Fenne Wouters, Florus J van der Giesen, Xanthe M E Matthijssen, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/10, 2019, Page(s) 1438-1439, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2019-215402

Contribution of tenosynovitis of small joints to the symptom morning stiffness in patients presenting with undifferentiated and rheumatoid arthritis

Author(s): AC Boer, DM Boeters, E Niemantsverdriet, AHM van der Helm-van Mil
Published in: Scandinavian Journal of Rheumatology, 2020, Page(s) 1-5, ISSN 0300-9742
DOI: 10.1080/03009742.2019.1696404

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia

Author(s): Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-2002-z

Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care

Author(s): L. E. Burgers, J. A. van der Pol, T. W. J. Huizinga, C. F. Allaart, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-1893-z

Rheumatoid Arthritis and Tenosynovitis at the Metatarsophalangeal Joints: An Anatomic and MRI Study of the Forefoot Tendon Sheaths

Author(s): Yousra J. Dakkak, Friso P. Jansen, Marco C. DeRuiter, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Radiology, Issue 295/1, 2020, Page(s) 146-154, ISSN 0033-8419
DOI: 10.1148/radiol.2020191725

Reliability of Magnetic Resonance Imaging (MRI) Scoring of the Metatarsophalangeal Joints of the Foot according to the Rheumatoid Arthritis MRI Score

Author(s): Yousra J. Dakkak, Xanthe M.E. Matthijssen, Désirée van der Heijde, Monique Reijnierse, Annette H. van der Helm-van Mil
Published in: The Journal of Rheumatology, 2019, Page(s) jrheum.190258, ISSN 0315-162X
DOI: 10.3899/jrheum.190258

Improving the feasibility of MRI in clinically suspect arthralgia for prediction of rheumatoid arthritis by omitting scanning of the feet

Author(s): Aleid C Boer, Fenne Wouters, Yousra J Dakkak, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2019, ISSN 1462-0324
DOI: 10.1093/rheumatology/kez436

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA

Author(s): Xanthe ME Matthijssen, Tom WJ Huizinga, Ellis Niemantsverdriet, Annette HM van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-215843, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2019-215843

ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

Author(s): Debbie M. Boeters, Leonie E. Burgers, Eric H. Sasso, Tom W. J. Huizinga, Annette H. M. van der Helm – van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
DOI: 10.1186/s13075-019-1902-2

Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis

Author(s): Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-2102-9

Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status

Author(s): Debbie M Boeters, Leonie E Burgers, René EM Toes, Annette van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/11, 2019, Page(s) 1497-1504, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2018-214868

Window of opportunity in rheumatoid arthritis – definitions and supporting evidence: from old to new perspectives

Author(s): Leonie E Burgers, Karim Raza, Annette H van der Helm - van Mil
Published in: RMD Open, Issue 5/1, 2019, Page(s) e000870, ISSN 2056-5933
DOI: 10.1136/rmdopen-2018-000870

The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis

Author(s): Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-02162-7

The value of the squeeze test for detection of subclinical synovitis in patients with arthralgia suspicious for progression to RA

Author(s): Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2020, ISSN 1462-0324
DOI: 10.1093/rheumatology/keaa082

Increased frequency of intermetatarsal and submetatarsal bursitis in early rheumatoid arthritis: a large case-controlled MRI study

Author(s): Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil, Monique Reijnierse
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
DOI: 10.1186/s13075-020-02359-w

Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population

Author(s): Xanthe M E Matthijssen, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2020, Page(s) annrheumdis-2020-217609, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2020-217609

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands

Author(s): Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Tom W. J. Huizinga, Annette H. M. van der Helm–van Mil
Published in: PLOS Medicine, Issue 17/9, 2020, Page(s) e1003296, ISSN 1549-1676
DOI: 10.1371/journal.pmed.1003296