Rheumatoid Arthritis Caught Early: investigating biological mechanisms preceding chronification of joint inflammation to identify patients prior to presentation of classic chronic arthritis

Publications

Patient burden and joint inflammation during development of RA from arthralgia: is it similar in ACPA-positive and ACPA-negative disease?

Author(s): Sarah J H Khidir, Doortje I Krijbolder, Herman K Glas, Elise van Mulligen, Annette H M van der Helm-van Mil
Published in: Rheumatology (Oxford), 2024, ISSN 0049-0172
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1093/rheumatology/keae044

Delayed Referral of Female Patients With Rheumatoid Arthritis: Where Are We Now? A Study Spanning 3 Decades.

Author(s): van Dijk BT, van der Helm-van Mil AHM.
Published in: Journal of Rheumatology, 2022, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.220429

Intermetatarsal bursitis, a novel feature of juxta-articular inflammation in early rheumatoid arthritis that is related to clinical signs: results of a longitudinal MRI-study

Author(s): Bastiaan T van Dijk, Yousra J Dakkak, Xanthe M E Matthijssen, Ellis Niemantsverdriet, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: Arthritis Care Res (Hoboken), 2021, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.24640

Joint Damage Over Time in Patients With Early Rheumatoid Arthritis Follows Trajectories Related to Distinct Courses of Disease Activity.

Author(s): Dumoulin QA, Verstappen M, van der Helm-van Mil AHM, van Steenbergen HW.
Published in: J Rheumatol, 2023, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.220531

ACPA-negative and ACPA-positive RA patients achieving disease resolution demonstrate distinct patterns of MRI-detected joint-inflammation.

Author(s): Verstappen M, Matthijssen XME, Connolly SE, Maldonado MA, Huizinga TWJ, van der Helm-van Mil AHM.
Published in: Rheumatology (Oxford), 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac294

Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

Author(s): Ellis Niemantsverdriet, Erik B. van den Akker, Debbie M. Boeters, Susan J. F. van den Eeden, Annemieke Geluk, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02361-2

Walking disabilities are associated with tenosynovitis at the metatarsophalangeal joints: A longitudinal MRI‐study in early arthritis

Author(s): Yousra J. Dakkak, Fenne Wouters, Xanthe M.E. Matthijssen, Monique Reijnierse, Annette H.M. van der Helm‐van Mil
Published in: Arthritis Care & Research, 2020, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.24452

Towards a simplified fluid-sensitive MRI protocol in small joints of the hand in early arthritis patients: reliability between modified Dixon and regular Gadolinium enhanced TSE fat saturated MRI-sequences.

Author(s): Boeren AMP, Niemantsverdriet E, Verstappen M, Wouters F, Bloem JL, Reijnierse M, van der Helm-van Mil AHM
Published in: Skeletal Radiol, 2022, ISSN 0364-2348
Publisher: Springer Verlag
DOI: 10.1007/s00256-022-04238-8

The value of MRI for detecting subclinical joint inflammation in clinically suspect arthralgia.

Author(s): Boeren AMP, Oei EHG, van der Helm-van Mil AHM.
Published in: RMD Open, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2021-002128

Preventive interventions in individuals at risk for Rheumatoid Arthritis: State of the art and perspectives

Author(s): van der Helm-van Mil AHM.
Published in: Joint Bone Spine, 2023, ISSN 1297-319X
Publisher: Elsevier Masson
DOI: 10.1016/j.jbspin.2023.105543

Value of imaging detected joint inflammation in explaining fatigue in RA at diagnosis and during the disease course: a large MRI study

Author(s): Matthijssen XME, Wouters F, Sidhu N, van der Helm-van Mil AHM
Published in: Ann Rheum Dis, 2021, ISSN 2056-5933
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2021-001599

Hand function is already reduced before RA development and reflects subclinical tenosynovitis

Author(s): Doortje Isabelle Krijbolder; Sarah J H Khidir; Xanthe M E Matthijssen; Robin M ten Brinck; Jill van Aken; Irene Speyer; Florus J van der Giesen; Elise van Mulligen; Annette H M van der Helm-van Mil
Published in: RMD Open, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2022-002885

Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways

Author(s): Matthijssen XME, Niemantsverdriet E, Le Cessie S, van der Helm-van Mil AHM
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa658

Do autoantibody-responses mature between presentation with arthralgia suspicious for progression to rheumatoid arthritis and development of clinically apparent inflammatory arthritis? A longitudinal serological study.

Author(s): Fenne Wouters; Ellis Niemantsverdriet; Nazike Salioska; Annemarie L. Dorjée; René E. M. Toes; Annette H M van der Helm-van Mil; Annette H M van der Helm-van Mil
Published in: Ann Rheum Dis, 2020, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-218221

No excess mortality in contemporary undifferentiated arthritis, in contrast to rheumatoid arthritis: a study with a follow-up of at least 10 years

Author(s): Marloes Verstappen and Tom WJ Huizinga and Annette HM van der Helm-van Mil
Published in: Ann Rheum Dis, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222145

Not only synovitis but also tenosynovitis needs to be considered: why it is time to update textbook images of rheumatoid arthritis

Author(s): Rogier C, Hayer S, van der Helm-van Mil AHM
Published in: Annals of the Rheumatic Diseases, 2019, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216350

DMARD-free remission as novel treatment target in rheumatoid arthritis: A systematic literature review of achievability and sustainability

Author(s): M Verstappen, E van Mulligen, P H P de Jong, A H M van der Helm-Van Mil
Published in: RMD Open, Issue 6/1, 2020, Page(s) e001220, ISSN 2056-5933
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2020-001220

Exploratory analysis of the TREAT EARLIER trial: is the efficacy of temporary methotrexate treatment dose-dependent?

Author(s): Doortje I Krijbolder, Hido D Boom, Annette H M van der Helm-van Mil
Published in: Lancet Rheumatology, 2023, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(23)00164-9

Morning stiffness precedes the development of RA and associates with systemic and subclinical joint inflammation in arthralgia patients

Author(s): Doortje I. Krijbolder, Fenne Wouters, Elise van Mulligen, Annette H.M. van der Helm-van Mil
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab651

Clinically suspect arthralgia patients with a low educational attainment have an increased risk of developing inflammatory arthritis.

Author(s): Khidir SJH, Boeren AMP, Boonen A, de Jong PHP, van Mulligen E, van der Helm-van Mil AHM
Published in: Rheumatology (Oxford)., 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac446

Work participation is reduced during the development of RA, months before clinical arthritis manifests

Author(s): Rogier C, de Jong PHP, van der Helm-van Mil AHM, van Mulligen E
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab793

Do magnetic resonance imaging-detected erosions predict progression to rheumatoid arthritis in patients presenting with clinically suspect arthralgia? A longitudinal study

Author(s): F Wouters, XME Matthijssen, DM Boeters, RM Ten Brinck, AHM Van Der Helm-Van Mil, E Niemantsverdriet
Published in: Scandinavian Journal of Rheumatology, Issue 49/6, 2020, Page(s) 461-467, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2020.1737221

a survey among participants of the TREAT EARLIER trial and healthcare professionals

Author(s): Doortje I Krijbolder; Sarah J H Khidir; Annette HM van der Helm-van Mil
Published in: RMD Open, 2023, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003031

Joint involvement in RA starts predominantly in the hands: functional, clinical and imaging studies in clinically suspect arthralgia and during progression to RA.

Author(s): Khidir SJH, van Dijk BT, Krijbolder DI, Verstappen M, van Mulligen E, van der Helm-van Mil AHM.
Published in: RMD Open, 2023, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003107

Patients with rheumatoid arthritis presenting with mono- or oligo-arthritis and high VAS-ratings remain the most fatigued during 5 years of follow-up

Author(s): Anna M P Boeren, Marloes Verstappen, Agnes E M Looijen, Pascal H P de Jong, Annette H M van der Helm-van Mil
Published in: Rheumatology (Oxford), 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kead429

Referring early arthritis patients within 6 weeks versus 12 weeks after symptom onset: an observational cohort study

Author(s): Ellis Niemantsverdriet, Maxime Dougados, Bernard Combe, Annette H M van der Helm-van Mil
Published in: The Lancet Rheumatology, Issue 2/6, 2020, Page(s) e332-e338, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(20)30061-8

Subclinical synovitis in arthralgia: how often does it result in clinical arthritis? Reflecting on starting points for disease-modifying anti-rheumatic drug treatment

Author(s): Rogier C, Wouters F, van Boheemen L, van Schaardenburg D, de Jong PHP, van der Helm-van Mil AHM
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa774

An ultrasound negative for subclinical synovitis in arthralgia patients: is it helpful in identifying those not developing arthritis?

Author(s): Rogier C, Frazzei G, Kortekaas MC, Verstappen M, Ohrndorf S, van Mulligen E, van Vollenhoven RF, van Schaardenburg D, de Jong PHP, van der Helm-van Mil AHM.
Published in: Rheumatology (Oxford), 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac239

Realising early recognition of arthritis in times of increased telemedicine: the value of patient-reported swollen joints

Author(s): Rogier C, van Dijk BT, Brouwer E, de Jong PHP, van der Helm-van Mil AHM
Published in: Annals of the Rheumatic Diseases, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219513

Correspondence on `Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis

Author(s): Quirine A Dumoulin and Xanthe M E Matthijssen and Fenne Wouters and Doortje I Krijbolder and Ellis Niemantsverdriet and Annette H M van der Helm-van Mil
Published in: Ann Rheum Dis, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220511

Undifferentiated arthritis; a changing population who did not benefit from enhanced DMARD-strategies – results from a 25-years longitudinal inception cohort

Author(s): M. Verstappen, X.M.E. Matthijssen, A.H.M. van der Helm-van Mil
Published in: Rheumatology (Oxford), 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab880

Which inflamed tissues explain a positive metatarsophalangeal squeeze test? A large imaging study to clarify a common diagnostic procedure.

Author(s): van Dijk BT, Dakkak YJ, Krijbolder DI, Jendé van Zeben D, Tchetverikov I, Reijnierse M, van der Helm-van Mil AHM.
Published in: Rheumatology (Oxford), 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac019

Tenosynovitis has a high sensitivity for early ACPA-positive and ACPA-negative RA: a large cross-sectional MRI study

Author(s): Matthijssen XME, Wouters F, Sidhu N, Niemantsverdriet E, van der Helm-van Mil A.
Published in: Ann Rheum Dis, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219302

Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis

Author(s): Wouters F, Maurits MP, van Boheemen L, Verstappen M, Mankia K, Matthijssen XME, Dorjée AL, Emery P, Knevel R, van Schaardenburg D, Toes REM, van der Helm-van Mil AHM.
Published in: Ann Rheum Dis, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220546

The Natural Sequence in Which Subclinical Inflamed Joint Tissues Subside or Progress to Rheumatoid Arthritis: A Study of Serial MRIs in the TREAT EARLIER Trial.

Author(s): Krijbolder DI, Matthijssen XME, van Dijk BT, van Steenbergen HW, Boeters DM, Willemze A, Schouffoer AA, van der Helm-van Mil AHM.
Published in: Arthritis Reumatol, 2023, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.42527

Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study.

Author(s): den Hollander NK, Verstappen M, Sidhu N, van Mulligen E, Reijnierse M, van der Helm-van Mil AHM.
Published in: Rheumatology (Oxford), 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac017

During development of rheumatoid arthritis, intermetatarsal bursitis may occur before clinical joint swelling: a large imaging study in patients with clinically suspect arthralgia

Author(s): Bastiaan T van Dijk, Fenne Wouters, Elise van Mulligen, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab830

The value of inquiring about functional impairments for early identification of inflammatory arthritis: a large cross-sectional derivation and validation study from the Netherlands

Author(s): Bastiaan van Dijk, Hanna W van Steenbergen, Ellis Niemantsverdriet, Elisabeth Brouwer, Annette van der Helm-van Mil
Published in: BMJ Open, Issue 10/12, 2020, Page(s) e040148, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-040148

Improving our understanding of the paradoxical protective effect of obesity on radiographic damage: a large magnetic resonance imaging-study in early arthritis.

Author(s): den Hollander NK, van der Helm-van Mil AHM, van Steenbergen HW.
Published in: Rheumatology (Oxford), 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kead320

Grip strength reduction in clinically suspect arthralgia: natural trajectories and improvement after treatment

Author(s): Krijbolder DI, Wouters F, Niemantsverdriet E, van der Helm-van Mil AHM.
Published in: RMD Open, 2023, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003110

Association of Interosseous Tendon Inflammation in the Hand with Different Early Arthritides in a Ten Year MRI Study

Author(s): Bastiaan T van Dijk, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: Artritis Rheumatol, 2023, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.42626

Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis

Author(s): M. Verstappen, E. Niemantsverdriet, X. M. E. Matthijssen, S. le Cessie, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02368-9

Preventing progression from arthralgia to arthritis: targeting the right patients

Author(s): Hanna W. van Steenbergen, José A. Pereira da Silva, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil
Published in: Nature Reviews Rheumatology, Issue 14/1, 2017, Page(s) 32-41, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/nrrheum.2017.185

The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it of additional benefit?

Author(s): Aleid C Boer, Debbie M Boeters, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2018-213143, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213143

Sequence of joint tissue inflammation during rheumatoid arthritis development

Author(s): R. M. ten Brinck, H. W. van Steenbergen, A. H. M. van der Helm–van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1756-z

Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

Author(s): Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1587-y

Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis

Author(s): Debbie M Boeters, Aleid C Boer, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/1, 2018, Page(s) 144-146, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213851

Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study

Author(s): Leonie E Burgers, Robin M ten Brinck, Annette H M van der Helm-van Mil
Published in: Rheumatology, Issue 58/1, 2018, Page(s) 86-93, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/key220

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia

Author(s): Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1824-z

Which patients presenting with arthralgia eventually develop rheumatoid arthritis? The current state of the art

Author(s): Debbie M Boeters, Karim Raza, Annette H M vander Helm-van Mil
Published in: RMD Open, Issue 3/2, 2017, Page(s) e000479, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2017-000479

Are MRI-detected erosions specific for RA? A large explorative cross-sectional study

Author(s): Debbie M Boeters, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Robert B M Landewé, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2017-212252, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212252

Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review

Author(s): Yousra J Dakkak, Désirée M van der Heijde, Monique Reijnierse, Annette H M van der Helm-van Mil
Published in: RMD Open, Issue 4/2, 2018, Page(s) e000796, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000796

Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example

Author(s): Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1591-2

Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis

Author(s): Aleid C Boer, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/1, 2018, Page(s) e1-e1, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212867

Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study

Author(s): L. E. Burgers, D. M. Boeters, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-018-1553-8

Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar

Author(s): Aleid C. Boer, Annelies Boonen, Annette H. M. van der Helm van Mil
Published in: Arthritis Care & Research, Issue 70/7, 2018, Page(s) 987-996, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.23497

Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis

Author(s): Robin M ten Brinck, Hanna W van Steenbergen, Annette H M van der Helm-van Mil
Published in: RMD Open, Issue 4/2, 2018, Page(s) e000748, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000748

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

Author(s): Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1845-7

Difficulties making a fist in clinically suspect arthralgia: an easy applicable phenomenon predictive for RA that is related to flexor tenosynovitis

Author(s): Fenne Wouters, Florus J van der Giesen, Xanthe M E Matthijssen, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/10, 2019, Page(s) 1438-1439, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215402

Contribution of tenosynovitis of small joints to the symptom morning stiffness in patients presenting with undifferentiated and rheumatoid arthritis

Author(s): AC Boer, DM Boeters, E Niemantsverdriet, AHM van der Helm-van Mil
Published in: Scandinavian Journal of Rheumatology, 2020, Page(s) 1-5, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2019.1696404

A search to the target tissue in which RA-specific inflammation starts: a detailed MRI study to improve identification of RA-specific features in the phase of clinically suspect arthralgia

Author(s): Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-2002-z

Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care

Author(s): L. E. Burgers, J. A. van der Pol, T. W. J. Huizinga, C. F. Allaart, A. H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1893-z

Rheumatoid Arthritis and Tenosynovitis at the Metatarsophalangeal Joints: An Anatomic and MRI Study of the Forefoot Tendon Sheaths

Author(s): Yousra J. Dakkak, Friso P. Jansen, Marco C. DeRuiter, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Radiology, Issue 295/1, 2020, Page(s) 146-154, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.2020191725

Reliability of Magnetic Resonance Imaging (MRI) Scoring of the Metatarsophalangeal Joints of the Foot according to the Rheumatoid Arthritis MRI Score

Author(s): Yousra J. Dakkak, Xanthe M.E. Matthijssen, Désirée van der Heijde, Monique Reijnierse, Annette H. van der Helm-van Mil
Published in: The Journal of Rheumatology, 2019, Page(s) jrheum.190258, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.190258

Improving the feasibility of MRI in clinically suspect arthralgia for prediction of rheumatoid arthritis by omitting scanning of the feet

Author(s): Aleid C Boer, Fenne Wouters, Yousra J Dakkak, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez436

Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA

Author(s): Xanthe ME Matthijssen, Tom WJ Huizinga, Ellis Niemantsverdriet, Annette HM van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-215843, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215843

ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

Author(s): Debbie M. Boeters, Leonie E. Burgers, Eric H. Sasso, Tom W. J. Huizinga, Annette H. M. van der Helm – van Mil
Published in: Arthritis Research & Therapy, Issue 21/1, 2019, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-019-1902-2

Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis

Author(s): Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-2102-9

Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status

Author(s): Debbie M Boeters, Leonie E Burgers, René EM Toes, Annette van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, Issue 78/11, 2019, Page(s) 1497-1504, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214868

Window of opportunity in rheumatoid arthritis – definitions and supporting evidence: from old to new perspectives

Author(s): Leonie E Burgers, Karim Raza, Annette H van der Helm - van Mil
Published in: RMD Open, Issue 5/1, 2019, Page(s) e000870, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2018-000870

The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis

Author(s): Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02162-7

The value of the squeeze test for detection of subclinical synovitis in patients with arthralgia suspicious for progression to RA

Author(s): Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa082

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

Author(s): HENDY KRISTYANTO, NIENKE J. BLOMBERG, LINDA M. SLOT, ELLEN I. H. VAN DER VOORT, PRISCILLA F. KERKMAN, ALEIDA BAKKER, LEONIE E. BURGERS, ROBIN M. TEN BRINCK, ANNETTE H. M. VAN DER HELM-VAN MIL, HERGEN SPITS, DOMINIQUE L. BAETEN, TOM W.J. HUIZINGA, RENÉ E. M. TOES, AND HANS U. SCHERER
Published in: Sci. Transl. Med, 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz5327

MRI detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis

Author(s): Navkiran Sidhu, Fenne Wouters, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Published in: Rheumatology (Oxford), 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab515

Automatic quantification of tenosynovitis on MRI of the wrist in patients with early arthritis: a feasibility study

Author(s): Evgeni Aizenberg, Denis P. Shamonin, Monique Reijnierse, Annette H. M. van der Helm-van Mil & Berend C. Stoel
Published in: EUR Radiol, 2018, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-018-5807-2

Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study.

Author(s): Dakkak YJ, van Dijk BT, Jansen FP, Wisse LJ, Reijnierse M, van der Helm-van Mil AHM, DeRuiter MC.
Published in: Arthritis Res Ther, 2022, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.1186/s13075-022-02841-7

Identifying MRI-detected inflammatory features specific for rheumatoid arthritis: two-fold feature reduction maintains predictive accuracy in clinically suspect arthralgia patients

Author(s): Aizenberg, E. and Ten Brinck, R. M. and Reijnierse, M. and van der Helm-van Mil, A. H. M. and Stoel, B. C.
Published in: Semin Arthritis Rheum, 2019, ISSN 0049-0172
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semarthrit.2018.04.005

Interosseous tendon inflammation in the hands of patients with clinically suspect arthralgia: analysis of {MRI} data from a prospective cohort study

Author(s): Bastiaan T van Dijk and Lambertus J Wisse and Hanna W van Steenbergen and Monique Reijnierse and Sarah J H Khidir and Marco C DeRuiter and Annette H M van der Helm-van Mil
Published in: Lancet Rheumatology, 2023, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(23)00129-7

Disentangling heterogeneity in contemporary undifferentiated arthritis – A large cohort study using latent class analysis

Author(s): N.K. den Hollander; M. Verstappen; B.T. van Dijk; A.H.M. van der Helm - van Mil; H.W. van Steenbergen
Published in: Semin Arthritis Rheum, Issue 22, 2023, ISSN 0049-0172
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semarthrit.2023.152251

When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk

Author(s): Dumoulin QA, Boeren AMP, Krijbolder DI, Willemze A, de Jong PHP, van Mulligen E, van Steenbergen H, van der Helm-van Mil AHM
Published in: RMD Open, 2024, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003785

Is shoulder involvement in clinically suspect arthralgia an early feature of rheumatoid arthritis? A longitudinal ultrasound study

Author(s): Rogier C, van der Ven M, van der Helm-van Mil AHM, de Jong PHP
Published in: Rheumatology, 2020, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keaa052

Increased frequency of intermetatarsal and submetatarsal bursitis in early rheumatoid arthritis: a large case-controlled MRI study

Author(s): Yousra J. Dakkak, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil, Monique Reijnierse
Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02359-w

Management of contemporary early undifferentiated arthritis: data on EULAR’s recommendation on the risk of persistent disease

Author(s): Nikolet K den Hollander and Marloes Verstappen and Tom WJ Huizinga and Annette van der Helm-van Mil
Published in: Ann Rheum Dis, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-221821

The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis.

Author(s): Heutz JW, Rogier C, Niemantsverdriet E, van den Eeden SJF, de Jong PHP, Lubberts E, Geluk A, van der Helm-van Mil AHM.
Published in: Rheumatology (Oxford), 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kead238

Unraveling heterogeneity within ACPA-negative rheumatoid arthritis; the subgroup of patients with a strong clinical and serological response to initiation of DMARD-treatment favor disease resolution

Author(s): M. Verstappen, H.W. van Steenbergen, P.H.P. de Jong, A.H.M. van der Helm-van Mil
Published in: Arthritis Research & Therapy, 2022, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02671-z

Patient-reported swelling in arthralgia patients at risk for rheumatoid arthritis: is it of value?

Author(s): Anna M P Boeren, Sarah J H Khidir, Pascal H P de Jong, Annette H M van der Helm-van Mil, Elise van Mulligen
Published in: Rheumatology (Oxford), 2023, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kead606

Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population

Author(s): Xanthe M E Matthijssen, Tom W J Huizinga, Annette H M van der Helm-van Mil
Published in: Annals of the Rheumatic Diseases, 2020, Page(s) annrheumdis-2020-217609, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-217609

The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study.

Author(s): Khidir SJH, Wouters F, van der Helm-van Mil AHM, van Mulligen E.
Published in: Joint Bone Spine, 2022, ISSN 1297-319X
Publisher: Elsevier Masson
DOI: 10.1016/j.jbspin.2022.105432

Comparison between 1.5T and 3.0T MRI: both field strengths sensitively detect subclinical inflammation of hand and forefoot in patients with arthralgia

Author(s): Doortje I. Krijbolder, Marloes Verstappen, Fenne Wouters, Leroy R. Lard, Petronella DM de Buck, Josien J.Veris-van Dieren, Johannes L. Bloem, Monique Reijnierse, Annette H.M. van der Helm-van Mil
Published in: Scandinavian Journal of Rheumatology, 2021, ISSN 0300-9742
Publisher: Taylor & Francis
DOI: 10.1080/03009742.2021.1935313

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands

Author(s): Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Tom W. J. Huizinga, Annette H. M. van der Helm–van Mil
Published in: PLOS Medicine, Issue 17/9, 2020, Page(s) e1003296, ISSN 1549-1676
Publisher: PLOS
DOI: 10.1371/journal.pmed.1003296

Author(s): Bastiaan T van Dijk; Anna M P Boeren; Sarah J H Khidir; Nikolet K den Hollander; Annette H.M. van der Helm - van Mil
Published in: RMD Open, 2024, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003895

Sustained DMARD-free remission in rheumatoid arthritis - about concepts and moving towards practice

Author(s): Verstappen M, van der Helm-van Mil AHM
Published in: Joint Bone Spine, 2022, ISSN 1297-319X
Publisher: Elsevier Masson
DOI: 10.1016/j.jbspin.2022.105418

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