Skip to main content

Decoding cell-to-cell variation in genome integrity maintenance


Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Author(s): Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Published in: Cell Reports, Issue 19/9, 2017, Page(s) 1819-1831, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.05.016

Inherited DNA lesions determine G1 duration in the next cell cycle

Author(s): Aleksandra Lezaja, Matthias Altmeyer
Published in: Cell Cycle, Issue 17/1, 2018, Page(s) 24-32, ISSN 1538-4101
DOI: 10.1080/15384101.2017.1383578

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Author(s): Michelena, Jone; Lezaja, Aleksandra; Teloni, Federico; Schmid, Thomas; Imhof, Ralph; Altmeyer, Matthias
Published in: Nature Communications, 2018, ISSN 2041-1723
DOI: 10.5167/uzh-152720

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

Author(s): Ina Klusmann, Kai Wohlberedt, Anna Magerhans, Federico Teloni, Jan O. Korbel, Matthias Altmeyer, Matthias Dobbelstein
Published in: Proceedings of the National Academy of Sciences, 2018, Page(s) 201809592, ISSN 0027-8424
DOI: 10.1073/pnas.1809592115

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Author(s): Sara Przetocka, Antonio Porro, Hella A. Bolck, Christina Walker, Aleksandra Lezaja, Anika Trenner, Christine von Aesch, Sarah-Felicitas Himmels, Alan D. D’Andrea, Raphael Ceccaldi, Matthias Altmeyer, Alessandro A. Sartori
Published in: Molecular Cell, Issue 72/3, 2018, Page(s) 568-582.e6, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.09.014

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

Author(s): Sinan Kilic, Aleksandra Lezaja, Marco Gatti, Eliana Bianco, Jone Michelena, Ralph Imhof, Matthias Altmeyer
Published in: The EMBO Journal, Issue 38/16, 2019, ISSN 0261-4189
DOI: 10.15252/embj.2018101379

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Author(s): Federico Teloni, Jone Michelena, Aleksandra Lezaja, Sinan Kilic, Christina Ambrosi, Shruti Menon, Jana Dobrovolna, Ralph Imhof, Pavel Janscak, Tuncay Baubec, Matthias Altmeyer
Published in: Molecular Cell, Issue 73/4, 2019, Page(s) 670-683.e12, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.11.036

Cells take a break when they are TIAR ed

Author(s): Matthias Altmeyer
Published in: EMBO reports, Issue 20/1, 2018, ISSN 1469-221X
DOI: 10.15252/embr.201847403


Inherited DNA lesions determine G1 duration in the next cell cycle

Author(s): Aleksandra Lezaja,Matthias Altmeyer
Published in: Figshare