Decoding cell-to-cell variation in genome integrity maintenance

Project Information

DiVineGenoMe

Grant agreement ID: 714326

DOI 10.3030/714326

Project closed

EC signature date 17 November 2016

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (24)

The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

Author(s): Simon, Anna K; Kummer, Sandra; Wild, Sebastian; Lezaja, Aleksandra; Teloni, Federico; Jozwiakowski, Stanislaw K; Altmeyer, Matthias; Gari, Kerstin
Published in: Life Science Alliance, Issue 2, 2020, ISSN 2575-1077
Publisher: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory

Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions

Author(s): Jone Michelena; Marco Gatti; Federico Teloni; Ralph Imhof; Matthias Altmeyer
Published in: The Journal of Cell Biology, Issue 00219525, 2019, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201902085

The Hammer and the Dance of Cell Cycle Control

Author(s): Andreas Panagopoulos, Matthias Altmeyer
Published in: Trends inBiochemical Sciences, Issue 09680004, 2021, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2020.11.002

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Author(s): Florian J Groelly 1 , Rebecca A Dagg 1 , Michalis Petropoulos 2 , Giacomo G Rossetti 2 , Birbal Prasad 1 , Andreas Panagopoulos, Teressa Paulsen 1 , Angeliki Karamichali 2 , Samuel E Jones 4 , Fena Ochs 5 , Vasilis S Dionellis 2 , Emilia Puig Lombardi 1 , Matthieu J Miossec 6 , Helen Lockstone 6 , Gaëlle Legube 7 , Andrew N Blackford 4 , Matthias Altmeyer 3 , Thanos D Halazonetis
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Author(s): Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer
Published in: Cell Reports, Issue 32/5, 2020, Page(s) 107985, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107985

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Author(s): Antonio Porro, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, Giulio Collotta, Keri M. Fishwick, Nour L. Mozaffari, Raphaël Guérois, Josef Jiricny, Matthias Altmeyer, Jean-Baptiste Charbonnier, Christopher E. Pearson, Alessandro A. Sartori
Published in: Science Advances, Issue 7/31, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf7906

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

Author(s): Indrajeet Ghodke, Michaela Remisova, Audrey Furst, Sinan Kilic, Bernardo Reina-San-Martin, Anna R. Poetsch,Matthias Altmeyer, Evi Soutoglou
Published in: Molecular Cell, 2021, ISSN 1097-2765
Publisher: Cell Press

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Author(s): Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A. Schmid, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17324-z

Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

Author(s): Ann-Katrin Hopp, Federico Teloni, Lavinia Bisceglie, Corentin Gondrand, Fabio Raith, Kathrin Nowak, Lukas Muskalla, Anna Howald, Patrick G A Pedrioli, Kai Johnsson, Matthias Altmeyer, Deena M Leslie Pedrioli, Michael O Hottiger
Published in: Molecular Cell, Issue 10972765, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.034

RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

Author(s): Bolck, Hella A; Przetocka, Sara; Meier, Roger; von Aesch, Christine; Zurfluh, Christina; Hänggi, Kay; Spegg, Vincent; Altmeyer, Matthias; Stebler, Michael; Nørrelykke, Simon F; Horvath, Peter; Sartori, Alessandro A; Porro, Antonio
Published in: Cells, 11 (4), Issue 20734409, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.5167/uzh-219090

Biomolecular condensates at sites of DNA damage: More than just a phase

Author(s): Vincent Spegg; Matthias Altmeyer
Published in: DNA repair, Issue 15687864, 2021, ISSN 1568-7864
Publisher: Elsevier BV
DOI: 10.1016/j.dnarep.2021.103179

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Author(s): Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Published in: Cell Reports, Issue 19/9, 2017, Page(s) 1819-1831, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.05.016

Inherited DNA lesions determine G1 duration in the next cell cycle

Author(s): Aleksandra Lezaja, Matthias Altmeyer
Published in: Cell Cycle, Issue 17/1, 2018, Page(s) 24-32, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2017.1383578

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Author(s): Michelena, Jone; Lezaja, Aleksandra; Teloni, Federico; Schmid, Thomas; Imhof, Ralph; Altmeyer, Matthias
Published in: Nature Communications, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.5167/uzh-152720

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

Author(s): Ina Klusmann, Kai Wohlberedt, Anna Magerhans, Federico Teloni, Jan O. Korbel, Matthias Altmeyer, Matthias Dobbelstein
Published in: Proceedings of the National Academy of Sciences, 2018, Page(s) 201809592, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1809592115

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Author(s): Sara Przetocka, Antonio Porro, Hella A. Bolck, Christina Walker, Aleksandra Lezaja, Anika Trenner, Christine von Aesch, Sarah-Felicitas Himmels, Alan D. D’Andrea, Raphael Ceccaldi, Matthias Altmeyer, Alessandro A. Sartori
Published in: Molecular Cell, Issue 72/3, 2018, Page(s) 568-582.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.09.014

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

Author(s): Sinan Kilic, Aleksandra Lezaja, Marco Gatti, Eliana Bianco, Jone Michelena, Ralph Imhof, Matthias Altmeyer
Published in: The EMBO Journal, Issue 38/16, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101379

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Author(s): Federico Teloni, Jone Michelena, Aleksandra Lezaja, Sinan Kilic, Christina Ambrosi, Shruti Menon, Jana Dobrovolna, Ralph Imhof, Pavel Janscak, Tuncay Baubec, Matthias Altmeyer
Published in: Molecular Cell, Issue 73/4, 2019, Page(s) 670-683.e12, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.11.036

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Author(s): Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19502-5

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

Author(s): Jone Michelena, Stefania Pellegrino, Vincent Spegg, Matthias Altmeyer
Published in: Life Science Alliance, Issue 4/6, 2021, Page(s) e202101023, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202101023

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Author(s): Porro, Antonio; Mohiuddin, Mohiuddin; Zurfluh, Christina; Spegg, Vincent; Dai, Jingqi; Iehl, Florence; Ropars, Virginie; Collotta, Giulio; Fishwick, Keri M.; Mozaffari, Nour L.; Guérois, Raphaël; Jiricny, Josef; Altmeyer, Matthias; Charbonnier, Jean-Baptiste; Pearson, Christopher E.; Sartori, Alessandro A.
Published in: Science Advances, Issue 1, 2022, ISSN 1097-2765
Publisher: Cell Press

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Author(s): Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23806-5

Dealing with DNA lesions: When one cell cycle is not enough

Author(s): Aleksandra Lezaja, Matthias Altmeyer
Published in: Current Opinion in Cell Biology, Issue 09550674, 2021, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.11.001

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells

Author(s): Chiara Balbo Pogliano 1 , Ilaria Ceppi 2 , Sara Giovannini 1 , Vasiliki Petroulaki 3 , Nathan Palmer 3 , Federico Uliana 1 , Marco Gatti 4 , Kristina Kasaciunaite 5 , Raimundo Freire 6 7 8 , Ralf Seidel 5 , Matthias Altmeyer 4 , Petr Cejka 1 2 , Joao Matos 1 3
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: AAAS

Non-peer reviewed articles (1)

Cells take a break when they are TIAR ed

Author(s): Matthias Altmeyer
Published in: EMBO reports, Issue 20/1, 2018, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201847403