Decoding cell-to-cell variation in genome integrity maintenance

Publikacje

The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

Autorzy: Simon, Anna K; Kummer, Sandra; Wild, Sebastian; Lezaja, Aleksandra; Teloni, Federico; Jozwiakowski, Stanislaw K; Altmeyer, Matthias; Gari, Kerstin
Opublikowane w: Life Science Alliance, Numer 2, 2020, ISSN 2575-1077
Wydawca: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory

Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions

Autorzy: Jone Michelena; Marco Gatti; Federico Teloni; Ralph Imhof; Matthias Altmeyer
Opublikowane w: The Journal of Cell Biology, Numer 00219525, 2019, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.201902085

The Hammer and the Dance of Cell Cycle Control

Autorzy: Andreas Panagopoulos, Matthias Altmeyer
Opublikowane w: Trends inBiochemical Sciences, Numer 09680004, 2021, ISSN 0968-0004
Wydawca: Elsevier BV
DOI: 10.1016/j.tibs.2020.11.002

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Autorzy: Florian J Groelly 1 , Rebecca A Dagg 1 , Michalis Petropoulos 2 , Giacomo G Rossetti 2 , Birbal Prasad 1 , Andreas Panagopoulos, Teressa Paulsen 1 , Angeliki Karamichali 2 , Samuel E Jones 4 , Fena Ochs 5 , Vasilis S Dionellis 2 , Emilia Puig Lombardi 1 , Matthieu J Miossec 6 , Helen Lockstone 6 , Gaëlle Legube 7 , Andrew N Blackford 4 , Matthias Altmeyer 3 , Thanos D Halazonetis
Opublikowane w: Molecular Cell, 2022, ISSN 1097-2765
Wydawca: Cell Press

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Autorzy: Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer
Opublikowane w: Cell Reports, Numer 32/5, 2020, Strona(/y) 107985, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2020.107985

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Autorzy: Antonio Porro, Mohiuddin Mohiuddin, Christina Zurfluh, Vincent Spegg, Jingqi Dai, Florence Iehl, Virginie Ropars, Giulio Collotta, Keri M. Fishwick, Nour L. Mozaffari, Raphaël Guérois, Josef Jiricny, Matthias Altmeyer, Jean-Baptiste Charbonnier, Christopher E. Pearson, Alessandro A. Sartori
Opublikowane w: Science Advances, Numer 7/31, 2021, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf7906

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

Autorzy: Indrajeet Ghodke, Michaela Remisova, Audrey Furst, Sinan Kilic, Bernardo Reina-San-Martin, Anna R. Poetsch,Matthias Altmeyer, Evi Soutoglou
Opublikowane w: Molecular Cell, 2021, ISSN 1097-2765
Wydawca: Cell Press

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Autorzy: Matteo Berti, Federico Teloni, Sofija Mijic, Sebastian Ursich, Jevgenij Fuchs, Maria Dilia Palumbieri, Jana Krietsch, Jonas A. Schmid, Edwige B. Garcin, Stéphanie Gon, Mauro Modesti, Matthias Altmeyer, Massimo Lopes
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17324-z

Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

Autorzy: Ann-Katrin Hopp, Federico Teloni, Lavinia Bisceglie, Corentin Gondrand, Fabio Raith, Kathrin Nowak, Lukas Muskalla, Anna Howald, Patrick G A Pedrioli, Kai Johnsson, Matthias Altmeyer, Deena M Leslie Pedrioli, Michael O Hottiger
Opublikowane w: Molecular Cell, Numer 10972765, 2021, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.12.034

RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

Autorzy: Bolck, Hella A; Przetocka, Sara; Meier, Roger; von Aesch, Christine; Zurfluh, Christina; Hänggi, Kay; Spegg, Vincent; Altmeyer, Matthias; Stebler, Michael; Nørrelykke, Simon F; Horvath, Peter; Sartori, Alessandro A; Porro, Antonio
Opublikowane w: Cells, 11 (4), Numer 20734409, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.5167/uzh-219090

Biomolecular condensates at sites of DNA damage: More than just a phase

Autorzy: Vincent Spegg; Matthias Altmeyer
Opublikowane w: DNA repair, Numer 15687864, 2021, ISSN 1568-7864
Wydawca: Elsevier BV
DOI: 10.1016/j.dnarep.2021.103179

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

Autorzy: Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Opublikowane w: Cell Reports, Numer 19/9, 2017, Strona(/y) 1819-1831, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2017.05.016

Inherited DNA lesions determine G1 duration in the next cell cycle

Autorzy: Aleksandra Lezaja, Matthias Altmeyer
Opublikowane w: Cell Cycle, Numer 17/1, 2018, Strona(/y) 24-32, ISSN 1538-4101
Wydawca: Landes Bioscience
DOI: 10.1080/15384101.2017.1383578

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Autorzy: Michelena, Jone; Lezaja, Aleksandra; Teloni, Federico; Schmid, Thomas; Imhof, Ralph; Altmeyer, Matthias
Opublikowane w: Nature Communications, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.5167/uzh-152720

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

Autorzy: Ina Klusmann, Kai Wohlberedt, Anna Magerhans, Federico Teloni, Jan O. Korbel, Matthias Altmeyer, Matthias Dobbelstein
Opublikowane w: Proceedings of the National Academy of Sciences, 2018, Strona(/y) 201809592, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1809592115

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Autorzy: Sara Przetocka, Antonio Porro, Hella A. Bolck, Christina Walker, Aleksandra Lezaja, Anika Trenner, Christine von Aesch, Sarah-Felicitas Himmels, Alan D. D’Andrea, Raphael Ceccaldi, Matthias Altmeyer, Alessandro A. Sartori
Opublikowane w: Molecular Cell, Numer 72/3, 2018, Strona(/y) 568-582.e6, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2018.09.014

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

Autorzy: Sinan Kilic, Aleksandra Lezaja, Marco Gatti, Eliana Bianco, Jone Michelena, Ralph Imhof, Matthias Altmeyer
Opublikowane w: The EMBO Journal, Numer 38/16, 2019, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.2018101379

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Autorzy: Federico Teloni, Jone Michelena, Aleksandra Lezaja, Sinan Kilic, Christina Ambrosi, Shruti Menon, Jana Dobrovolna, Ralph Imhof, Pavel Janscak, Tuncay Baubec, Matthias Altmeyer
Opublikowane w: Molecular Cell, Numer 73/4, 2019, Strona(/y) 670-683.e12, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2018.11.036

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Autorzy: Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-19502-5

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

Autorzy: Jone Michelena, Stefania Pellegrino, Vincent Spegg, Matthias Altmeyer
Opublikowane w: Life Science Alliance, Numer 4/6, 2021, Strona(/y) e202101023, ISSN 2575-1077
Wydawca: Life Science Alliance
DOI: 10.26508/lsa.202101023

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

Autorzy: Porro, Antonio; Mohiuddin, Mohiuddin; Zurfluh, Christina; Spegg, Vincent; Dai, Jingqi; Iehl, Florence; Ropars, Virginie; Collotta, Giulio; Fishwick, Keri M.; Mozaffari, Nour L.; Guérois, Raphaël; Jiricny, Josef; Altmeyer, Matthias; Charbonnier, Jean-Baptiste; Pearson, Christopher E.; Sartori, Alessandro A.
Opublikowane w: Science Advances, Numer 1, 2022, ISSN 1097-2765
Wydawca: Cell Press

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Autorzy: Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23806-5

Dealing with DNA lesions: When one cell cycle is not enough

Autorzy: Aleksandra Lezaja, Matthias Altmeyer
Opublikowane w: Current Opinion in Cell Biology, Numer 09550674, 2021, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2020.11.001

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells

Autorzy: Chiara Balbo Pogliano 1 , Ilaria Ceppi 2 , Sara Giovannini 1 , Vasiliki Petroulaki 3 , Nathan Palmer 3 , Federico Uliana 1 , Marco Gatti 4 , Kristina Kasaciunaite 5 , Raimundo Freire 6 7 8 , Ralf Seidel 5 , Matthias Altmeyer 4 , Petr Cejka 1 2 , Joao Matos 1 3
Opublikowane w: Science Advances, 2022, ISSN 2375-2548
Wydawca: AAAS

Cells take a break when they are TIAR ed

Autorzy: Matthias Altmeyer
Opublikowane w: EMBO reports, Numer 20/1, 2018, ISSN 1469-221X
Wydawca: Nature Publishing Group
DOI: 10.15252/embr.201847403

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