Tracking and predicting neurodegeneration spreading across the brain connectome

Project Information

NeuroTRACK

Grant agreement ID: 714388

DOI 10.3030/714388

Project closed

EC signature date 23 March 2017

Start date 1 April 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 496 994,00

EU contribution € 1 496 994,00

Coordinated by

OSPEDALE SAN RAFFAELE SRL
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Italian reference values and brain correlates of verbal fluency index - vs standard verbal fluency test - to assess executive dysfunction in ALS

Author(s): Elisa Canu, Veronica Castelnovo, Paola MV Rancoita, Michela Leocadi, Alessandra Lamanuzzi, Edoardo Gioele Spinelli, Silvia Basaia, Nilo Riva, Barbara Poletti, Federica Solca, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Sharon Abrahams, Massimo Filippi, Federica Agosta
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Issue 24, 2023, Page(s) 457-465, ISSN 2167-8421
Publisher: Informa Healthcare
DOI: 10.1080/21678421.2023.2167606

Semantic and right temporal variant of FTD: Next generation sequencing genetic analysis on a single-center cohort

Author(s): Giacomina Rossi, Erika Salvi, Elkadia Mehmeti, Martina Ricci, Cristina Villa, Sara Prioni, Fabio Moda, Giuseppe Di Fede, Pietro Tiraboschi, Veronica Redaelli, Cinzia Coppola, Giacomo Koch, Elisa Canu, Massimo Filippi, Federica Agosta, Giorgio Giaccone, Paola Caroppo
Published in: Frontiers in Aging Neuroscience, Issue 14, 2022, Page(s) 1085406, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.1085406

The human functional connectome in neurodegenerative diseases: relationship to pathology and clinical progression

Author(s): Massimo Filippi, Edoardo Gioele Spinelli, Camilla Cividini, Alma Ghirelli, Silvia Basaia, Federica Agosta
Published in: Expert Review of Neurotherapeutics, Issue 23, 2023, Page(s) 59-73, ISSN 1473-7175
Publisher: Future Drugs Ltd.
DOI: 10.1080/14737175.2023.2174016

Combining semi-quantitative rating and automated brain volumetry in MRI evaluation of patients with probable behavioural variant of fronto-temporal dementia: an added value for clinical practise?

Author(s): Sonia Francesca Calloni; Paolo Quintiliano Vezzulli; Antonella Castellano; Riccardo Leone; Silvia Basaia; Almar von Loon; Edoardo Gioele Spinelli; Giuseppe Magnani; Francesca Caso; Federica Agosta; Massimo Filippi; Andrea Falini
Published in: Neuroradiology, Issue 65, 2023, Page(s) 1025-1035, ISSN 0028-3940
Publisher: Springer Verlag
DOI: 10.1007/s00234-023-03133-w

Amyotrophic Lateral Sclerosis-Frontotemporal Dementia: Shared and Divergent Neural Correlates Across the Clinical Spectrum

Author(s): Camilla Cividini, Silvia Basaia, Edoardo G Spinelli, Elisa Canu, Veronica Castelnovo, Nilo Riva, Giordano Cecchetti, Francesca Caso, Giuseppe Magnani, Andrea Falini, Massimo Filippi, Federica Agosta
Published in: Neurology, Issue 98, 2022, Page(s) e402-e415, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000013123

Profiling morphologic MRI features of motor neuron disease caused by TARDBP mutations

Author(s): Edoardo Gioele Spinelli, Alma Ghirelli, Nilo Riva, Elisa Canu, Veronica Castelnovo, Teuta Domi, Laura Pozzi, Paola Carrera, Vincenzo Silani, Adriano Chiò, Massimo Filippi, Federica Agosta
Published in: Frontiers in Neurology, Issue 13, 2022, Page(s) 931006, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.931006

Age-related vulnerability of the human brain connectome

Author(s): Massimo Filippi, Camilla Cividini, Silvia Basaia, Edoardo G Spinelli, Veronica Castelnovo, Michela Leocadi, Elisa Canu, Federica Agosta
Published in: Molecular Psychiatry, 2023, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02157-1

A novel GRN mutation in an Italian patient with non-fluent variant of primary progressive aphasia at onset: a longitudinal case report

Author(s): Veronica Castelnovo; Elisa Canu; Teuta Domi; Laura Pozzi; Francesca Vignaroli; Edoardo Gioele Spinelli; Alma Ghirelli; Giacomo Tondo; Cristoforo Comi; Nilo Riva; Angelo Quattrini; Paola Carrera; Massimo Filippi; Federica Agosta
Published in: Frontiers in Neuroscience, Issue 1, 2023, Page(s) 1204504, ISSN 1662-453X
Publisher: Frontiers.org
DOI: 10.3389/fnins.2023.1204504

Measuring social cognition in frontotemporal lobar degeneration: a clinical approach.

Author(s): Maria Antonietta Magno; Elisa Canu; Federica Agosta; Massimo Filippi
Published in: Journal of Neurology, Issue 269, 2022, Page(s) 2227-2244, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-021-10889-9

Case report: coexistence of C9orf72 expansion and progranulin mutation in a case of genetic frontotemporal dementia—clinical features and neuroimaging correlates

Author(s): Alma Ghirelli; Edoardo Gioele Spinelli; Elisa Canu; Teuta Domi; Silvia Basaia; Veronica Castelnovo; Laura Pozzi; Giuseppe Magnani; Francesca Caso; Paola Caroppo; Sara Prioni; Cristina Villa; Nilo Riva; Angelo Quattrini; Paola Carrera; Massimo Filippi; Federica Agosta
Published in: Journal of Neurology, Issue 270, 2023, Page(s) 5102-5109, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-023-11839-3

Pallidal functional connectivity changes are associated with disgust recognition in pure motor amyotrophic lateral sclerosis

Author(s): Veronica Castelnovo; Elisa Canu; Maria Antonietta Magno; Elena Gatti; Nilo Riva; Debora Pain; Gabriele Mora; Barbara Poletti; Vincenzo Silani; Massimo Filippi; Federica Agosta
Published in: Neuroimage Clinical, Issue 35, 2022, Page(s) 103145, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2022.103145

Basal ganglia alterations in amyotrophic lateral sclerosis

Author(s): Veronica Castelnovo, Elisa Canu, Filippo De Mattei, Massimo Filippi, Federica Agosta
Published in: Frontiers in Neuroscience, Issue 17, 2023, Page(s) 1133758, ISSN 1662-453X
Publisher: Frontiers.org
DOI: 10.3389/fnins.2023.1133758

Brain structural abnormalities and cognitive changes in a patient with 17q21.31 microduplication and early onset dementia: a case report

Author(s): Michela Leocadi; Elisa Canu; Camilla Cividini; Tommaso Russo; Giordano Cecchetti; Claudia Celico; Rosalinda Cardamone; Valeria Barcella; Giuseppe Magnani; Federica Agosta; Massimo Filippi
Published in: Journal of Neurology, Issue 270, 2023, Page(s) 1127-1134, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-022-11423-1

Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement

Author(s): Veronica Castelnovo, Elisa Canu, Maria Antonietta Magno, Silvia Basaia, Nilo Riva, Barbara Poletti, Vincenzo Silani, Massimo Filippi, Federica Agosta
Published in: Neuroimage Clinical, Issue 32, 2021, Page(s) 102803, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2021.102803

MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family

Author(s): Cristina Villa, Giacomina Rossi, Ilaria Bizzozero, Sara Prioni, Chiara Boiocchi, Federica Agosta, Elisa Canu, Massimo Filippi, Giorgio Giaccone, Paola Caroppo
Published in: European Journal of Neurology, Issue 29, 2022, Page(s) 1529-1533, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.15250

Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis

Author(s): Yuri Matteo Falzone; Teuta Domi; Alessandra Mandelli; Laura Pozzi; Paride Schito; Tommaso Russo; Alessandra Barbieri; Raffaella Fazio; Maria Antonietta Volontè; Giuseppe Magnani; Ubaldo Del Carro; Paola Carrera; Andrea Malaspina; Federica Agosta; Angelo Quattrini; Roberto Furlan; Massimo Filippi; Nilo Riva
Published in: European Journal of Neurology, Issue 29, 2022, Page(s) 1930-1939, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.15321

Structural MRI Signatures in Genetic Presentations of the Frontotemporal Dementia/Motor Neuron Disease Spectrum

Author(s): Edoardo Gioele Spinelli, Alma Ghirelli, Silvia Basaia, Camilla Cividini, Nilo Riva, Elisa Canu, Veronica Castelnovo, Teuta Domi, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Giacomina Rossi, Lucio Tremolizzo, Ildebrando Appollonio, Vincenzo Silani, Paola Carrera, Massimo Filippi, Federica Agosta
Published in: Neurology, Issue 97, 2021, Page(s) e1594-e1607, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000012702

Functional Connectivity From Disease Epicenters in Frontotemporal Dementia

Author(s): Federica Agosta, Edoardo Gioele Spinelli, Silvia Basaia, Camilla Cividini, Francesco Falbo, Costanza Pavone, Nilo Riva, Elisa Canu, Veronica Castelnovo, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Lucio Tremolizzo, Ildebrando Appollonio, Vincenzo Silani, Keith A Josephs, Jennifer Whitwell, Massimo Filippi
Published in: Neurology, Issue 100, 2023, Page(s) e2290-e2303, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000207277

White Matter Microstructure Breakdown in the Motor Neuron Disease Spectrum: Recent Advances Using Diffusion Magnetic Resonance Imaging

Author(s): Silvia Basaia, Massimo Filippi, Edoardo G. Spinelli, Federica Agosta
Published in: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2019.00193

Awareness impairment in Alzheimer’s disease and frontotemporal dementia: a systematic MRI review

Author(s): Michela Leocadi; Elisa Canu; Angela Paldino; Federica Agosta; Massimo Filippi
Published in: Journal of Neurology, Issue 270, 2023, Page(s) 1880-1907, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-022-11518-9

Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration

Author(s): Elisa Canu, Davide Calderaro, Veronica Castelnovo, Silvia Basaia, Maria Antonietta Magno, Nilo Riva, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Debora Pain, Gabriele Mora, Lucio Tremolizzo, Ildebrando Appollonio, Barbara Poletti, Vincenzo Silani, Massimo Filippi, Federica Agosta
Published in: Molecular Psychiatry, Issue 27, 2022, Page(s) 4809-4821, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01612-9

Social cognition in the FTLD spectrum: evidence from MRI.

Author(s): Maria Antonietta Magno; Elisa Canu; Massimo Filippi; Federica Agosta
Published in: Journal of Neurology, Issue 269, 2022, Page(s) 2245-2258, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-021-10892-0