The evolutionary ecology of bacterial immune mechanisms

Project Information

EVOIMMECH

Grant agreement ID: 714478

DOI 10.3030/714478

Project closed

EC signature date 28 October 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 337,00

EU contribution € 1 498 337,00

Coordinated by

THE UNIVERSITY OF EXETER
United Kingdom

Publications

Peer reviewed articles (20)

Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity

Author(s): Sean Meaden, Loris Capria, Ellinor Alseth, Sylvain Gandon, Ambarish Biswas, Luca Lenzi, Stineke van Houte, Edze R. Westra
Published in: The ISME Journal, Issue 15/2, 2021, Page(s) 534-544, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-020-00794-w

Coevolution between bacterial CRISPR-Cas systems and their bacteriophages

Author(s): Bridget N.J. Watson, Jurre A. Steens, Raymond H.J. Staals, Edze R. Westra, Stineke van Houte
Published in: Cell Host & Microbe, Issue 29/5, 2021, Page(s) 715-725, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.03.018

Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity

Author(s): Mariann Landsberger, Sylvain Gandon, Sean Meaden, Clare Rollie, Anne Chevallereau, Hélène Chabas, Angus Buckling, Edze R. Westra, Stineke van Houte
Published in: Cell, Issue 174/4, 2018, Page(s) 908-916.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.05.058

The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity

Author(s): Anne Chevallereau, Sean Meaden, Stineke van Houte, Edze R. Westra, Clare Rollie
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180094, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0094

Variability in the durability of CRISPR-Cas immunity

Author(s): Hélène Chabas, Antoine Nicot, Sean Meaden, Edze R. Westra, Denise M. Tremblay, Léa Pradier, Sébastien Lion, Sylvain Moineau, Sylvain Gandon
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180097, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0097

Evolutionary emergence of infectious diseases in heterogeneous host populations

Author(s): Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M. Wahl, Edze R. Westra, Sylvain Gandon
Published in: PLOS Biology, Issue 16/9, 2018, Page(s) e2006738, ISSN 1545-7885
Publisher: PLoS
DOI: 10.1371/journal.pbio.2006738

CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage

Author(s): Jack Common, Daniel Morley, Edze R. Westra, Stineke van Houte
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180098, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0098

CRISPR-Cas antimicrobials: Challenges and future prospects

Author(s): Elizabeth Pursey, David Sünderhauf, William H. Gaze, Edze R. Westra, Stineke van Houte
Published in: PLOS Pathogens, Issue 14/6, 2018, Page(s) e1006990, ISSN 1553-7374
Publisher: PLoS
DOI: 10.1371/journal.ppat.1006990

CRISPR evolution and bacteriophage persistence in the context of population bottlenecks

Author(s): Jack Common, Edze R. Westra
Published in: RNA Biology, Issue 16/4, 2018, Page(s) 588-594, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2019.1578608

Recombination between phages and CRISPR−cas loci facilitates horizontal gene transfer in staphylococci

Author(s): Andrew Varble, Sean Meaden, Rodolphe Barrangou, Edze R. Westra, Luciano A. Marraffini
Published in: Nature Microbiology, Issue 4/6, 2019, Page(s) 956-963, ISSN 2058-5276
Publisher: Nature press
DOI: 10.1038/s41564-019-0400-2

Addiction systems antagonize bacterial adaptive immunity

Author(s): Lisa van Sluijs, Stineke van Houte, John van der Oost, Stan JJ Brouns, Angus Buckling, Edze R Westra
Published in: FEMS Microbiology Letters, Issue 366/5, 2019, ISSN 1574-6968
Publisher: Oxford academic
DOI: 10.1093/femsle/fnz047

Exploitation of the Cooperative Behaviors of Anti-CRISPR Phages

Author(s): Anne Chevallereau, Sean Meaden, Olivier Fradet, Mariann Landsberger, Alice Maestri, Ambarish Biswas, Sylvain Gandon, Stineke van Houte, Edze R. Westra
Published in: Cell Host & Microbe, 2019, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.12.004

The effect of phage genetic diversity on bacterial resistance evolution

Author(s): Jenny M. Broniewski, Sean Meaden, Steve Paterson, Angus Buckling, Edze R. Westra
Published in: The ISME Journal, 2020, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-019-0577-7

Targeting of temperate phages drives loss of type I CRISPR–Cas systems

Author(s): Clare Rollie, Anne Chevallereau, Bridget N. J. Watson, Te-yuan Chyou, Olivier Fradet, Isobel McLeod, Peter C. Fineran, Chris M. Brown, Sylvain Gandon, Edze R. Westra
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-1936-2

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance

Author(s): Ellinor O. Alseth, Elizabeth Pursey, Adela M. Luján, Isobel McLeod, Clare Rollie, Edze R. Westra
Published in: Nature, Issue 574/7779, 2019, Page(s) 549-552, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1662-9

It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements

Author(s): Edze R. Westra, Bruce R. Levin
Published in: Proceedings of the National Academy of Sciences, Issue 117/45, 2020, Page(s) 27777-27785, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1915966117

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Author(s): Tatiana Dimitriu, Mark D. Szczelkun, Edze R. Westra
Published in: Current Biology, Issue 30/19, 2020, Page(s) R1189-R1202, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.08.028

Avoidance of Self during CRISPR Immunization

Author(s): Jake L. Weissman, Arlin Stoltzfus, Edze R. Westra, Philip L.F. Johnson
Published in: Trends in Microbiology, Issue 28/7, 2020, Page(s) 543-553, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2020.02.005

The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa

Author(s): Jenny M. Broniewski, Matthew A. W. Chisnall, Nina Molin Høyland-Kroghsbo, Angus Buckling, Edze R. Westra
Published in: The ISME Journal, 2021, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-021-00946-6

Diversity in CRISPR‐based immunity protects susceptible genotypes by restricting phage spread and evolution

Author(s): Jack Common, David Walker‐Sünderhauf, Stineke Houte, Edze R. Westra
Published in: Journal of Evolutionary Biology, Issue 33/8, 2020, Page(s) 1097-1108, ISSN 1010-061X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13638

Non-peer reviewed articles (1)

The ecology and evolution of microbial CRISPR-Cas adaptive immune systems

Author(s): Edze R. Westra, Stineke van Houte, Sylvain Gandon, Rachel Whitaker
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20190101, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0101