Periodic Reporting for period 4 - HP4all (Persistent and Transportable Hyperpolarization for Magnetic Resonance)
Período documentado: 2021-07-01 hasta 2022-12-31
1) designed and built a dDNP polarizer and successfully achieved state-of-the-art performances. We have equipped this polarizer with a new generation of 3D-printed NMR coil for cross-polarization experiments.
S. J. Elliott, M. Ceillier, O. Cala, Q. Stern, S. F. Cousin, and S. Jannin, Simple and Cost-Effective Cross-Polarization Experiments under Dissolution-Dynamic Nuclear Polarization Conditions with a 3D-Printed 1H-13C Background-Free Radiofrequency Coil, J. Magn. Reson. Open, 10, 100033 (IF=2.2)
M. Baudin, B. Vuichoud, A. Bornet, G. Bodenhausen, S. Jannin, A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T, J. Magn. Reson. 294, 115, (2018).
2) worked on methods for improving polarization transfers and studying spin relaxation and diffusion. This work was published in various journals, from NMR specialized to general audiences such as Science Advances.
S. J. Elliott, Q. Stern, O. Cala, S. Jannin, Protonation-tuned dipolar order mediated 1H→13C cross-polarization for dissolution-dynamic nuclear polarization experiments, Solid-State Nucl. Magn. Reson., vol 116, 101762, 2021
S. J. Elliott, O. Cala, Q. Stern, S. F. Cousin, D. Eshchenko, R. Melzi, J. G. Kempf, and S. Jannin, Pulse sequence and sample formulation optimization for dipolar order mediated1H→13C cross-polarization, Phys. Chem. Chem. Phys., vol. 23, no. 15, pp. 9457–9465, 2021,
S. J. Elliott, O. Cala, Q. Stern, S. F. Cousin, M. Ceillier, V. Decker, and S. Jannin Boosting Dissolution-Dynamic Nuclear Polarization by Multiple-Step Dipolar Order Mediated 1H→13C Cross-Polarization, J. Magn. Reson. Open, p. 100018, Apr. 2021, (IF=2.2)
Q. Stern, S. F. Cousin, F. Mentink-Vigier, A. C. Pinon, S. J. Elliott, O. Cala, and S. Jannin. Direct observation of hyperpolarization breaking through the spin diffusion barrier. Sci. Adv., vol. 7, no. 18, pp. 1–14, 2021 (IF=14.1)
S. J. Elliott, S. F. Cousin, Q Chappuis, O Cala, M Ceillier, A Bornet, and S Jannin, Dipolar order mediated 1H → 13C cross-polarization for dissolution-dynamic nuclear polarization, Magn. Reson. 1, 89, (2020).
3) synthesized micro-architectured hyperpolarizing matrices that enabled the preparation of long-lived hyperpolarization with lifetimes exceeding hours. This finding was published in Nature Communications.
T. El Daraï, S. F. Cousin, Q. Stern, M. Ceillier, J. Kempf, D. Eshchenko, R. Melzi, M. Schnell, L. Gremillard, A. Bornet, J. Milani, B. Vuichoud, O. Cala, D. Montarnal, and S. Jannin, Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites, Nat. Commun., vol. 12, no. 1, pp. 1–9, (2021)
4) developed hardware for the final injection of the hyperpolarized compounds which was published in an NMR-specialized journal:
M. Ceillier, O. Cala, T. El Daraï, S. F. Cousin, Q. Stern, S. Guibert, S. J. Elliott, A. Bornet, B. Vuichoud, J. Milani, C. Pages, D. Eshchenko, J. G. Kempf, C. Jose, S. A. Lambert, and S. Jannin, An automated system for fast transfer and injection of hyperpolarized solutions, J. Magn. Reson. Open, vol. 8–9, p. 100017, 2021,