Long-term Investigation of Functional Excitatory Synapses: Linking Plasticity, Network Wiring and Memory Storage

Project Information

LIFE synapses

Grant agreement ID: 714762

DOI 10.3030/714762

Project closed

EC signature date 9 December 2016

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publications

Peer reviewed articles (14)

Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation

Author(s): Wei Yang, Mattia Chini, Jastyn A. Pöpplau, Andrey Formozov, Alexander Dieter, Patrick Piechocinski, Cynthia Rais, Fabio Morellini, Olaf Sporns, Ileana L. Hanganu-Opatz, J. Simon Wiegert
Published in: PLOS Biology, Issue 19/4, 2021, Page(s) e3001146, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3001146

Orthogonally-polarized excitation for improved two-photon and second-harmonic-generation microscopy, applied to neurotransmitter imaging with GPCR-based sensors

Author(s): Mauro Pulin; Kilian E. Stockhausen; Olivia A. Masseck; Martin Kubitschke; Björn Busse; J. Simon Wiegert; Thomas G. Oertner
Published in: Biomed Opt Express, Issue 1, 2022, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.448760

BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons

Author(s): Johannes Vierock, Silvia Rodriguez-Rozada, Alexander Dieter, Florian Pieper, Ruth Sims, Federico Tenedini, Amelie C. F. Bergs, Imane Bendifallah, Fangmin Zhou, Nadja Zeitzschel, Joachim Ahlbeck, Sandra Augustin, Kathrin Sauter, Eirini Papagiakoumou, Alexander Gottschalk, Peter Soba, Valentina Emiliani, Andreas K. Engel, Peter Hegemann, J. Simon Wiegert
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24759-5

Calcium Imaging and Electrophysiology of hippocampal Activity under Anesthesia and natural Sleep in Mice

Author(s): Andrey Formozov, Mattia Chini, Alexander Dieter, Wei Yang, Jastyn A. Pöpplau, Ileana L. Hanganu-Opatz & J. Simon Wiegert
Published in: Scientific Data, 2022, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1038/s41597-022-01244-2

Crystal structure of the red light-activated channelrhodopsin Chrimson

Author(s): Kazumasa Oda, Johannes Vierock, Satomi Oishi, Silvia Rodriguez-Rozada, Reiya Taniguchi, Keitaro Yamashita, J. Simon Wiegert, Tomohiro Nishizawa, Peter Hegemann, Osamu Nureki
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06421-9

Silencing Neurons: Tools, Applications, and Experimental Constraints

Author(s): J. Simon Wiegert, Mathias Mahn, Matthias Prigge, Yoav Printz, Ofer Yizhar
Published in: Neuron, Issue 95/3, 2017, Page(s) 504-529, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.06.050

Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses

Author(s): Nordine Helassa, Céline D. Dürst, Catherine Coates, Silke Kerruth, Urwa Arif, Christian Schulze, J. Simon Wiegert, Michael Geeves, Thomas G. Oertner, Katalin Török
Published in: Proceedings of the National Academy of Sciences, Issue 115/21, 2018, Page(s) 5594-5599, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1720648115

The fate of hippocampal synapses depends on the sequence of plasticity-inducing events

Author(s): J Simon Wiegert, Mauro Pulin, Christine Elizabeth Gee, Thomas G Oertner
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.39151

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

Author(s): Jonas Wietek, Silvia Rodriguez-Rozada, Janine Tutas, Federico Tenedini, Christiane Grimm, Thomas G. Oertner, Peter Soba, Peter Hegemann, J. Simon Wiegert
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-14330-y

MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins

Author(s): Johannes Oppermann, Paul Fischer, Arita Silapetere, Bernhard Liepe, Silvia Rodriguez-Rozada, José Flores-Uribe, Enrico Peter, Anke Keidel, Johannes Vierock, Joel Kaufmann, Matthias Broser, Meike Luck, Franz Bartl, Peter Hildebrandt, J. Simon Wiegert, Oded Béjà, Peter Hegemann, Jonas Wietek
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11322-6

Monosynaptic Hippocampal-Prefrontal Projections Contribute to Spatial Memory Consolidation in Mice

Author(s): Sonja Binder, Matthias Mölle, Michael Lippert, Ralf Bruder, Sonat Aksamaz, Frank Ohl, J. Simon Wiegert, Lisa Marshall
Published in: The Journal of Neuroscience, Issue 39/35, 2019, Page(s) 6978-6991, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2158-18.2019

High-speed imaging of glutamate release with genetically encoded sensors

Author(s): Céline D. Dürst, J. Simon Wiegert, Nordine Helassa, Silke Kerruth, Catherine Coates, Christian Schulze, Michael A. Geeves, Katalin Török, Thomas G. Oertner
Published in: Nature Protocols, Issue 14/5, 2019, Page(s) 1401-1424, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0143-9

Spike-timing-dependent plasticity rewards synchrony rather than causality

Author(s): Margarita Anisimova; Bas van Bommel; Rui Wang; Marina Mikhaylova; Jörn Simon Wiegert; Thomas G Oertner; Christine E Gee
Published in: Crossref, Issue 2, 2022, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhac050

Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin

Author(s): Mathias Mahn, Inbar Saraf-Sinik, Pritish Patil, Mauro Pulin, Eyal Bitton, Nikolaos Karalis, Felicitas Bruentgens, Shaked Palgi, Asaf Gat, Julien Dine, Jonas Wietek, Ido Davidi, Rivka Levy, Anna Litvin, Fangmin Zhou, Kathrin Sauter, Peter Soba, Dietmar Schmitz, Andreas Lüthi, Benjamin R. Rost, J. Simon Wiegert, Ofer Yizhar
Published in: Neuron, Issue 109/10, 2021, Page(s) 1621-1635.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.03.013

Non-peer reviewed articles (1)

Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics

Author(s): Ofer Yizhar, J. Simon Wiegert
Published in: Trends in Pharmacological Sciences, Issue 40/6, 2019, Page(s) 362-364, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.04.010

Other (1)

Freeze-frame imaging of synaptic activity using SynTagMA

Author(s): Alberto Perez-Alvarez, Brenna C. Fearey, Christian Schulze, Ryan J. O’Toole, Benjamien Moeyaert, Manuel A. Mohr, Ignacio Arganda-Carreras, Wei Yang, J. Simon Wiegert, Eric R. Schreiter, Christine E. Gee, Michael B. Hoppa, Thomas G. Oertner
Published in: bioRxiv, 2019
Publisher: bioRxiv.org
DOI: 10.1101/538041