Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEaling

Project Information

APACHE

Grant agreement ID: 714793

DOI 10.3030/714793

Project closed

EC signature date 15 March 2017

Start date 1 April 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 887,00

EU contribution € 1 499 887,00

Coordinated by

UNIVERSITAT POLITECNICA DE CATALUNYA
Spain

Publications

Peer reviewed articles (19)

Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures

Author(s): Juan Tornin, Cédric Labay, Francesco Tampieri, Maria-Pau Ginebra, Cristina Canal
Published in: Nature Protocols, Issue 16/6, 2021, Page(s) 2826-2850, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00521-5

Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cancer

Author(s): Miguel Mateu-Sanz; María-Pau Ginebra; Juan Tornín; Cristina Canal
Published in: instname:Universitat Politècnica de Catalunya (UPC), Issue 189, 2022, Page(s) 32-41, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.07.007

Ceramic‐hydrogel composite as carrier for cold‐plasma reactive‐species: Safety and osteogenic capacity in vivo

Author(s): Xavi Solé‐Martí; Cédric Labay; Yago Raymond; Jordi Franch; Raul Benitez; Maria‐Pau Ginebra; Cristina Canal
Published in: Plasma Processes and Polymers, Issue 20, 2023, Page(s) e2200155, ISSN 1612-8850
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/ppap.202200155

Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy

Author(s): Miguel Mateu-Sanz, Juan Tornin, Maria-Pau Ginebra, Cristina Canal
Published in: J. Clin. Med., Issue 10, 2021, Page(s) 893, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10040893

Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties

Author(s): Juan Tornín, Aranzazu Villasante, Xavi Solé-Martí, Maria-Pau Ginebra, Cristina Canal
Published in: Free Radical Biology and Medicine, Issue 164, 2021, Page(s) 107-118, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2020.12.437

Current State of Cold Atmospheric Plasma and Cancer-Immunity Cycle: Therapeutic Relevance and Overcoming Clinical Limitations Using Hydrogels

Author(s): Milica Živanić, Albert Espona-Noguera, Abraham Lin, Cristina Canal
Published in: Advanced Science, 2023, Page(s) 2205803, ISSN 2198-3844
Publisher: John Wiley & Sons
DOI: 10.1002/advs.202205803

Can we remove tattoos with non-thermal atmospheric plasma?

Author(s): Francesco Tampieri; Ariadna G. Araguz; Cristina Canal
Published in: PLASMA PROCESSES AND POLYMERS, Issue 2, 2022, Page(s) e2100188, ISSN 1612-8850
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/ppap.202100188

Plasma-induced selectivity in bone cancer cells death

Author(s): Cristina Canal, Raul Fontelo, Ines Hamouda, Jordi Guillem-Marti, Uros Cvelbar, Maria-Pau Ginebra
Published in: Free Radical Biology and Medicine, Issue 110, 2017, Page(s) 72-80, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.05.023

Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief review

Author(s): Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
Published in: Frontiers of Chemical Science and Engineering, Issue 13/2, 2019, Page(s) 238-252, ISSN 2095-0179
Publisher: Higher Education Press
DOI: 10.1007/s11705-019-1801-8

Generation Of Reactive Species By Plasma Needle In Different Liquids

Author(s): Inés Hamouda, Alix Gouhier, Cédric Labay, Maria-Pau Ginebra, Cristina Canal
Published in: Clinical Plasma Medicine, Issue 9, 2018, Page(s) 34-35, ISSN 2212-8166
Publisher: Elsevier GmbH
DOI: 10.1016/j.cpme.2017.12.054

Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma

Author(s): Juan Tornin, Miguel Mateu-Sanz, Aida Rodríguez, Cédric Labay, Rene Rodríguez, Cristina Canal
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-47128-1

Production of reactive species in alginate hydrogels for cold atmospheric plasma-based therapies

Author(s): Cédric Labay, Inès Hamouda, Francesco Tampieri, Maria-Pau Ginebra, Cristina Canal
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) 16160, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-52673-w

Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma

Author(s): Miguel Mateu-Sanz, Juan Tornín, Bénédicte Brulin, Anna Khlyustova, Maria-Pau Ginebra, Pierre Layrolle, Cristina Canal
Published in: Cancers, Issue 12/1, 2020, Page(s) 227, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12010227

Investigating the atmospheric pressure plasma jet modification of a photo-crosslinkable hydrogel

Author(s): Inès Hamouda, Cédric Labay, Maria Pau Ginebra, Erwan Nicol, Cristina Canal
Published in: Polymer, Issue 192, 2020, Page(s) 122308, ISSN 0032-3861
Publisher: Elsevier BV
DOI: 10.1016/j.polymer.2020.122308

Selectivity of direct plasma treatment and plasma-conditioned media in bone cancer cell lines

Author(s): Inès Hamouda, Cédric Labay, Uroš Cvelbar, Maria-Pau Ginebra, Cristina Canal
Published in: Scientific Reports, Issue 11/1, 2021, Page(s) All, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-96857-9

Quantification of Plasma-Produced Hydroxyl Radicals in Solution and their Dependence on the pH

Author(s): Francesco Tampieri, Maria-Pau Ginebra, Cristina Canal
Published in: Analytical Chemistry, Issue 93/8, 2021, Page(s) 3666-3670, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c04906

Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions

Author(s): Xavi Solé-Martí, Albert Espona-Noguera, Maria-Pau Ginebra, Cristina Canal
Published in: Cancers, Issue 13/3, 2021, Page(s) 452, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030452

Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death

Author(s): Cédric Labay, Marcel Roldán, Francesco Tampieri, Augusto Stancampiano, Pablo Escot Bocanegra, Maria-Pau Ginebra, Cristina Canal
Published in: ACS Applied Materials & Interfaces, Issue 12/42, 2020, Page(s) 47256-47269, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c12930

Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose

Author(s): Xavi Solé-Martí; Tània Vilella; Cédric Labay; Francesco Tampieri; Maria-Pau Ginebra; Cristina Canal
Published in: Biomaterials Science, Issue 10, 2022, Page(s) 3845, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2bm00308b

Non-peer reviewed articles (1)

Application of Plasma Technology in Bioscience and Biomedicine

Author(s): Daniela Boehm, Cristina Canal
Published in: Applied Sciences, Issue 11/16, 2021, Page(s) 7203, ISSN 2076-3417
Publisher: Basel, Switzerland
DOI: 10.3390/app11167203

Conference proceedings (6)

Influence of the composition of plasma-activated medium on osteosarcoma

Author(s): Cristina Canal, Juan Tornín, Miguel Mateu, Inés Hamouda, Cédric Labay, Jordi Guillem, Maria-Pau Ginebra
Published in: International Conference on Plasma Medicine (ICPM7) Book of abstracts, Issue 7, 2018
Publisher: International Society on Plasma Medicine

Influence of process parameters in the generation of reactive oxygen and nitrogen species in cell culture media by atmospheric pressure plasma jet

Author(s): Canal Barnils, Cristina; Humbert, Marjolaine; Guillem Martí, Jordi; Ginebra Molins, Maria Pau
Published in: International Conference on Plasmas with liquids (ICPL2017) Book of abstracts, Issue 2, 2017, Page(s) 109, ISBN 978-80-87026-07-6
Publisher: Organization of ICPL 2017

Liquid-mediated effects of cold plasma on bone cancer

Author(s): Canal Barnils, Cristina; Hamouda, Ines; Guillem Martí, Jordi; Ginebra Molins, Maria Pau
Published in: "Book of abstracts - International Symposium on Plasma Nanoscience and Nanotechnology. ""iPlasmaNano-VIII 2017""", Issue 1, 2017, Page(s) 68
Publisher: University of Antwerp

Modification of hydrogel-based biomaterials by atmospheric pressure plasma to enhance tissue regeneration

Author(s): Cédric Labay, Inés Hamouda, Maria-Pau Ginebra, Cristina Canal
Published in: 7th International Conference on Plasma Medicine (ICPM7) Book of abstracts, Issue 1, 2018, Page(s) 4
Publisher: International Society on Plasma Medicine

Plasma jet selectivity on bone cancer cells and liquid-mediated effects

Author(s): Canal Barnils, Cristina; Humbert, Marjolaine; Guillem Martí, Jordi; Ginebra Molins, Maria Pau
Published in: International Workshop on Plasma for Cancer Treatment - Book of Abstracts, Issue 1, 2017, Page(s) 34
Publisher: International Workshop on Plasma for Cancer Treatment

Modification of hydrogel-based biomaterials by atmospheric pressure plasma to enhance tissue regeneration

Author(s): Cédric Labay,Inès Hamouda, Maria Pau Ginebra, Cristina Canal
Published in: International Conference on Plasma Medicine (ICPM7) Book of abstracts, 2018
Publisher: International Society of Plasma