Objective Your brain has its own waterscape: whether you are reading or sleeping, fluid flows through the brain tissue and clears waste in the process. These physiological processes are crucial for the well-being of the brain. In spite of their importance we understand them but little. Mathematics and numerics could play a crucial role in gaining new insight. Indeed, medical doctors express an urgent need for multiscale modeling of water transport through the brain, to overcome limitations in traditional techniques. Surprisingly little attention has been paid to the numerics of the brain's waterscape however, and fundamental knowledge is missing.In response, the Waterscales ambition is to establish the mathematical and computational foundations for predictively modeling fluid flow and solute transport through the brain across scales -- from the cellular to the organ level. The project aims to bridge multiscale fluid mechanics and cellular electrophysiology to pioneer new families of mathematical models that couple macroscale, mesoscale and microscale flow with glial cell dynamics. For these models, we will design numerical discretizations that preserve key properties and that allow for whole organ simulations. To evaluate predictability, we will develop a new computational platform for model adaptivity and calibration. The project is multidisciplinary combining mathematics, mechanics, scientific computing, and physiology.If successful, this project enables the first in silico studies of the brain's waterscape across scales. The new models would open up a new research field within computational neuroscience with ample opportunities for further mathematical and more applied study. The processes at hand are associated with neurodegenerative diseases e.g. dementia and with brain swelling caused by e.g. stroke. The Waterscales project will provide the field with a sorely needed, new avenue of investigation to understand these conditions, with tremendous long-term impact. Fields of science medical and health sciencesbasic medicineneurologydementiamedical and health sciencesbasic medicineneurologystrokenatural sciencesbiological sciencesneurobiologycomputational neurosciencenatural sciencescomputer and information sciencescomputational sciencemultiphysicsnatural sciencesmathematicsapplied mathematicsmathematical model Keywords Numerical methods for partial differential equations: mathematical and computational aspects with applications in physiology medicine Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2016-STG - ERC Starting Grant Call for proposal ERC-2016-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Host institution SIMULA RESEARCH LABORATORY AS Net EU contribution € 1 500 000,00 Address KRISTIAN AUGUST GATE 23 0164 Oslo Norway See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 500 000,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SIMULA RESEARCH LABORATORY AS Norway Net EU contribution € 1 500 000,00 Address KRISTIAN AUGUST GATE 23 0164 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 500 000,00
