Mitochondrial methylation and its role in health and disease

Project Information

MitoMethylome

Grant agreement ID: 715009

DOI

10.3030/715009

Project closed

EC signature date 28 November 2016

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 999,25

EU contribution

€ 1 499 999,25

Coordinated by

KAROLINSKA INSTITUTET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits

Author(s): Florian A. Schober, Ilian Atanassov, David Moore, Javier Calvo-Garrido, Marco F. Moedas, Anna Wedell, Christoph Freyer, Anna Wredenberg
Published in: Molecular & Cellular Proteomics, Issue 20, 2021, Page(s) 100065, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100065

ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing

Author(s): Paula Clemente, Javier Calvo-Garrido, Sarah F. Pearce, Florian A. Schober, Megumi Shigematsu, Stefan J. Siira, Isabelle Laine, Henrik Spåhr, Christian Steinmetzger, Katja Petzold, Yohei Kirino, Rolf Wibom, Oliver Rackham, Aleksandra Filipovska, Joanna Rorbach, Christoph Freyer and Anna Wredenberg
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33368-9

Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease

Author(s): Florian A Schober, Jia Xin Tang, Kate Sergeant, Marco F Moedas, Charlotte M Zierz, David Moore, Conrad Smith, David Lewis, Nishan Guha, Sila Hopton, Gavin Falkous, Amanda Lam, Angela Pyle, Joanna Poulton, Gráinne S Gorman, Robert W Taylor, Christoph Freyer, and Anna Wredenberg
Published in: Human Molecular Genetics, 2022, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddac002

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo

Author(s): Aleksandra Pajak, Isabelle Laine, Paula Clemente, Najla El-Fissi, Florian A. Schober, Camilla Maffezzini, Javier Calvo-Garrido, Rolf Wibom, Roberta Filograna, Ashish Dhir, Anna Wedell, Christoph Freyer, Anna Wredenberg
Published in: PLOS Genetics, Issue 15/7, 2019, Page(s) e1008240, ISSN 1553-7404
Publisher: PLOS Genetics
DOI: 10.1371/journal.pgen.1008240

The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters

Author(s): Florian A. Schober, David Moore, Ilian Atanassov, Marco F. Moedas, Paula Clemente, Ákos Végvári, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Käll, Anna Wedell, Christoph Freyer, Anna Wredenberg
Published in: Science Advances, Issue 7/8, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abf0717

Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7

Author(s): Sandrina P. Correia, Marco F. Moedas, Karin Naess, Helene Bruhn, Camilla Maffezzini, Javier Calvo‐Garrido, Nicole Lesko, Rolf Wibom, Florian A. Schober, Anders Jemt, Henrik Stranneheim, Christoph Freyer, Anna Wedell, Anna Wredenberg
Published in: Human Mutation, Issue 42/4, 2021, Page(s) 378-384, ISSN 1059-7794
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/humu.24173

Book chapters (1)

Quantitative Proteomics in Drosophila with Holidic Stable-Isotope Labeling of Amino Acids in Fruit Flies (SILAF)

Author(s): Florian A. Schober, Ilian Atanassov, Christoph Freyer, Anna Wredenberg
Published in: Mitochondrial Gene Expression - Methods and Protocols, Issue 2192, 2021, Page(s) 75-87, ISBN 978-1-0716-0833-3
Publisher: Springer US
DOI: 10.1007/978-1-0716-0834-0_7

Other (1)

Versatile proteome labelling in fruit flies with SILAF

Author(s): Florian A. Schober, Ilian Atanassov, David Moore, Anna Wedell, Christoph Freyer, Anna Wredenberg
Published in: BioRxiv, 2019
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/590315