High-throughput combinatorial chemical protein synthesis as a novel research technology platform for chemical and synthetic biology

Project Information

HiChemSynPro

Grant agreement ID: 715062

DOI

10.3030/715062

Project closed

EC signature date 23 November 2016

Start date 1 March 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Aggregation and Amyloidogenicity of the Nuclear Coactivator Binding Domain of CREB‐Binding Protein

Author(s): Ana Maria Garcia; Christophe Giorgiutti; Youssef El Khoury; Valentin Bauer; Coralie Spiegelhalter; Emmanuelle Leize-Wagner; Petra Hellwig; Noëlle Potier; Vladimir Yu. Torbeev
Published in: Chemistry - A European Journal, Issue 26, 2020, Page(s) 9889-9899, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001847

Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides.

Author(s): Katarzyna Ożga; Łukasz Berlicki; Ana M. Garcia; Manuela Grelich-Mucha; Joanna Olesiak-Banska; Vladimir Torbeev
Published in: The Journal of Physical Chemistry B, Issue 125, 2021, Page(s) 5502-5510, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.1c00808

Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site

Author(s): Elise A. Naudin; Alastair G. McEwen; Sophia K. Tan; Pierre Poussin-Courmontagne; Jean-Louis Schmitt; Catherine Birck; William F. DeGrado; Vladimir Torbeev
Published in: Journal of the American Chemical Society, Issue 143, 2021, Page(s) 3330-3339, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c10053

Chemical synthesis of transactivation domain (TAD) of tumor suppressor protein p53 by native chemical ligation of three peptide segments

Author(s): Abhishek Baral, Aromal Asokan, Valentin Bauer, Bruno Kieffer, Vladimir Torbeev
Published in: Tetrahedron, Issue 75/6, 2019, Page(s) 703-708, ISSN 0040-4020
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2018.11.074

Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue

Author(s): Régis Boehringer, Bruno Kieffer, Vladimir Torbeev
Published in: Chemical Science, Issue 9/25, 2018, Page(s) 5594-5599, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc01790e

Conformational editing of intrinsically disordered protein by α-methylation

Author(s): Valentin Bauer; Boris Schmidtgall; Gergő Gógl; Jozica Dolenc; Judit Osz; Yves Nominé; Camille Kostmann; Alexandra Cousido-Siah; Andre Mitschler; Natacha Rochel; Gilles Travé; Bruno Kieffer; Vladimir Yu. Torbeev
Published in: Chemical Science, Issue 12, 2021, Page(s) 1080-1089, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc04482b

Book chapters (1)

Deciphering Protein Folding Using Chemical Protein Synthesis

Author(s): Vladimir Torbeev
Published in: Total Chemical Synthesis of Proteins, 2021, Page(s) 357-382, ISBN 9783527346608
Publisher: WILEY‐VCH GmbH
DOI: 10.1002/9783527823567.ch13