Inflammation is auto-regulated and needed to defend the organism from pathogens and preserve tissue homeostasis. Chronic inflammation, however, is characterized by infiltrating inflammatory cells, excess cytokine production and deregulation of cell signaling pathways, and has been associated with many diseases including neurodegenerative, cardiovascular, metabolic bone and muscular. Although the cellular and molecular events involved in response to acute inflammation or tissue damage are well understood, less is known about the causes and molecular mechanisms that mediate systemic chronic inflammation. This type of inflammation doesn´t appear to be caused by typical inflammation instigators, as is the case with infections or damaging agents. Instead, they are induced by tissue malfunction and a progressive loss in tissue homeostasis.The progressive loss of tissue homeostasis and the accumulation of damaged cells are directly associated with aging. In the majority of age-related diseases, patients exhibit an underlying chronic inflammatory state, characterized by a local infiltration of inflammatory cells, mostly macrophages, and elevated levels of pro-inflammatory circulatory cytokines.
Our group is interested in understanding how chronic inflammation may accelerate the aging process. Specifically, we want to study how immune cell metabolism may act as a therapeutic target in delaying aging and age-associated diseases.
The activation, expansion, differentiation and the regression to homeostasis of immune cells are processes associated with metabolic changes. Following antigen recognition, T cells are activated and initiate a proliferation phase characterized by a metabolic change similar to the Warburg effect described in tumoral cells. This metabolic reprogramming could be advantageous for cells that proliferate rapidly, such as cancerous or immune cells. T-cell differentiation and functional fate could be altered by modulating its metabolism. These results have opened up a new field of research, known as immunometabolism, that studies metabolic regulation in the immune response and is currently considered a promising therapeutic window in cancer and autoimmune disease research.
Our major scientific interest involves studying the role of metabolic regulation in the inflammatory response, and defining how immunometabolism may be used as a therapeutic tool in inflammatory diseases and pathologies associated with aging.
In summary, using a multidisciplinary approach we had explored immunometabolism as a new therapeutic target against chronic inflammation and aging.
