Mapping metabolic regulators at a genome-scale to switch bacteria from growth to overproduction of chemicals

Project Information

MapMe

Grant agreement ID: 715650

DOI

10.3030/715650

Project closed

EC signature date 5 October 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 461 200,00

EU contribution

€ 1 461 200,00

Coordinated by

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry

Author(s): Farke N, Schramm T, Verhülsdonk A, Rapp J, Link H
Published in: Analytical Biochemistry, 2023, ISSN 1096-0309
Publisher: Elsevier
DOI: 10.1016/j.ab.2023.115036

Multi-omics Analysis of CRISPRi-Knockdowns Identifies Mechanisms that Buffer Decreases of Enzymes in E. coli Metabolism

Author(s): Stefano Donati, Michelle Kuntz, Vanessa Pahl, Niklas Farke, Dominik Beuter, Timo Glatter, José Vicente Gomes-Filho, Lennart Randau, Chun-Ying Wang, Hannes Link
Published in: Cell Systems, Issue 12, 2020, Page(s) 1-12, ISSN 2405-4712
Publisher: Cell Systems
DOI: 10.1016/j.cels.2020.10.011

Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance

Author(s): Timur Sander, Niklas Farke, Christoph Diehl, Michelle Kuntz, Timo Glatter, Hannes Link
Published in: Cell Systems, Issue 8/1, 2019, Page(s) 66-75.e8, ISSN 2405-4712
Publisher: Elsevier
DOI: 10.1016/j.cels.2018.12.005

Broadening the Scope of Enforced ATP Wasting as a Tool for Metabolic Engineering in Escherichia coli

Author(s): Simon Boecker, Ahmed Zahoor, Thorben Schramm, Hannes Link, Steffen Klamt
Published in: Biotechnology Journal, 2019, Page(s) 1800438, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800438

Systematic identification of metabolites controlling gene expression in E. coli

Author(s): Martin Lempp, Niklas Farke, Michelle Kuntz, Sven Andreas Freibert, Roland Lill, Hannes Link
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12474-1

High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli

Author(s): Thorben Schramm, Martin Lempp, Dominik Beuter, Silvia González Sierra, Timo Glatter, Hannes Link
Published in: Metabolic Engineering, Issue 60, 2020, Page(s) 14-24, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2020.03.004

Dynamic fluctuations in a bacterial metabolic network

Author(s): Shuangyu Bi, Manika Kargeti, Remy Colin, Niklas Farke, Hannes Link, Victor Sourjik
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37957-0

Homeostasis of the biosynthetic E. coli metabolome

Author(s): Radoš D, Donati S, Lempp M, Rapp J, Link H
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.104503