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The chemical understanding of biomolecular recognition in epigenetics

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Publications

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins

Author(s): Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Chemical Communications, Issue 54/19, 2018, Page(s) 2409-2412, ISSN 1359-7345
DOI: 10.1039/c8cc01009a

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Author(s): Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Published in: Chemical Communications, Issue 53/99, 2017, Page(s) 13264-13267, ISSN 1359-7345
DOI: 10.1039/c7cc08028j

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation

Author(s): Bas J. G. E. Pieters, Jordi C. J. Hintzen, Yvonne Grobben, Abbas H. K. Al Temimi, Jos J. A. G. Kamps, Jasmin Mecinović
Published in: Bioconjugate Chemistry, Issue 30/3, 2019, Page(s) 952-958, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.9b00065

The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis

Author(s): Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin Mecinović
Published in: Communications Chemistry, Issue 2/1, 2019, Page(s) 112, ISSN 2399-3669
DOI: 10.1038/s42004-019-0210-8

γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones

Author(s): Abbas H. K. Al Temimi, Renate van der Wekken-de Bruijne, Giordano Proietti, Hong Guo, Ping Qian, Jasmin Mecinović
Published in: Bioconjugate Chemistry, Issue 30/6, 2019, Page(s) 1798-1804, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.9b00313

Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Author(s): Abbas H. K. Al Temimi, Paul B. White, Marcus J. M. Mulders, Nicole G. A. van der Linden, Richard H. Blaauw, Anita Wegert, Floris P. J. T. Rutjes, Jasmin Mecinović
Published in: Chemical Communications, Issue 56/20, 2020, Page(s) 3039-3042, ISSN 1359-7345
DOI: 10.1039/c9cc09098c

Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis

Author(s): Abbas H. K. Al Temimi, Vu Tran, Ruben S. Teeuwen, Arthur J. Altunc, Helene I. V. Amatdjais-Groenen, Paul B. White, Danny C. Lenstra, Giordano Proietti, Yali Wang, Anita Wegert, Richard H. Blaauw, Ping Qian, Wansheng Ren, Hong Guo, Jasmin Mecinović
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-60337-3

Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins

Author(s): Jordi C. J. Hintzen, Jordi Poater, Kiran Kumar, Abbas H. K. Al Temimi, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Molecules, Issue 25/8, 2020, Page(s) 1918, ISSN 1420-3049
DOI: 10.3390/molecules25081918

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

Author(s): Bas J. G. E. Pieters, Maud H. M. Wuts, Jordi Poater, Kiran Kumar, Paul B. White, Jos J. A. G. Kamps, Woody Sherman, Ger J. M. Pruijn, Robert S. Paton, Thijs Beuming, F. Matthias Bickelhaupt, Jasmin Mecinović
Published in: Communications Chemistry, Issue 3/1, 2020, Page(s) 69, ISSN 2399-3669
DOI: 10.1038/s42004-020-0313-2

Biomolecular Recognition of Methylated Histones

Author(s): Miriam R. B. Porzberg, Bas J. G. E. Pieters, Jasmin Mecinović
Published in: The DNA, RNA, and Histone Methylomes, 2019, Page(s) 435-451
DOI: 10.1007/978-3-030-14792-1_17