Gut microbiota-dependent tryptophan metabolism: role in disease pathogenesis and therapeutic target

Project Information

MODulATE

Grant agreement ID: 715776

DOI

10.3030/715776

Project closed

EC signature date 12 December 2016

Start date 1 March 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 495 525,00

EU contribution

€ 1 495 525,00

Coordinated by

SORBONNE UNIVERSITE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Author(s): Modoux M, Rolhion N, Lefevre JH, Oeuvray C, Nádvorník P, Illes P, Emond P, Parc Y, Mani S, Dvorak Z, Sokol H.
Published in: Gut Microbes, 2022, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2022.2105637

Linking Strain Engraftment in Fecal Microbiota Transplantation With Maintenance of Remission in Crohn's Disease.

Author(s): Kong L, Lloyd-Price J, Vatanen T, Seksik P, Beaugerie L, Simon T, Vlamakis H, Sokol H, Xavier RJ
Published in: Gastroenterology, Issue 00165085, 2020, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.08.045

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation.

Author(s): Lamas B, Hernandez-Galan L, Galipeau HJ, Constante M, Clarizio A, Jury J, Breyner NM, Caminero A, Rueda G, Hayes CL, McCarville JL, Bermudez Brito M, Planchais J, Rolhion N, Murray JA, Langella P, Loonen LMP, Wells JM, Bercik P, Sokol H, Verdu EF
Published in: Science Translational Medicine, Issue 19466234, 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba0624

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

Author(s): Michela Miani, Julie Le Naour, Emmanuelle Waeckel-Enée, Subash chand Verma, Marjolène Straube, Patrick Emond, Bernhard Ryffel, Peter van Endert, Harry Sokol, Julien Diana
Published in: Cell Metabolism, Issue 28/4, 2018, Page(s) 557-572.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.06.012

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Author(s): Ludivine Laurans, Nicolas Venteclef, Yacine Haddad, Mouna Chajadine, Fawaz Alzaid, Sarvenaz Metghalchi, Bruno Sovran, Raphael G. P. Denis, Julien Dairou, Marina Cardellini, Jose-Maria Moreno-Navarrete, Marjolene Straub, Sarah Jegou, Claire McQuitty, Thomas Viel, Bruno Esposito, Bertrand Tavitian, Jacques Callebert, Serge H. Luquet, Massimo Federici, José Manuel Fernandez-Real, Remy Burcelin, Jean
Published in: Nature Medicine, Issue 24/8, 2018, Page(s) 1113-1120, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-018-0060-4

Aryl hydrocarbon receptor and intestinal immunity

Author(s): Bruno Lamas, Jane M. Natividad, Harry Sokol
Published in: Mucosal Immunology, Issue 11/4, 2018, Page(s) 1024-1038, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-018-0019-2

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Author(s): Allison Agus, Julien Planchais, Harry Sokol
Published in: Cell Host & Microbe, Issue 23/6, 2018, Page(s) 716-724, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2018.05.003

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

Author(s): Jane M. Natividad, Allison Agus, Julien Planchais, Bruno Lamas, Anne Charlotte Jarry, Rebeca Martin, Marie-Laure Michel, Caroline Chong-Nguyen, Ronan Roussel, Marjolene Straube, Sarah Jegou, Claire McQuitty, Maude Le Gall, Gregory da Costa, Emmanuelle Lecornet, Chloé Michaudel, Morgane Modoux, Jeremy Glodt, Chantal Bridonneau, Bruno Sovran, Louise Dupraz, Andre Bado, Mathias L. Richard, Philippe
Published in: Cell Metabolism, 2018, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.07.001

The Gut Microbiota at the Service of Immunometabolism

Author(s): Michaudel C, Sokol H
Published in: Cell Metabolism, Issue 15504131, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.09.004

Tryptophan Metabolism as a Pharmacological Target.

Author(s): Modoux M, Rolhion N, Mani S, Sokol H.
Published in: Trends Pharmacol Sci, Issue 18733735, 2020, ISSN 1873-3735
Publisher: Elsevier
DOI: 10.1016/j.tips.2020.11.006

Gut microbiota-derived metabolites as central regulators in metabolic disorders.

Author(s): Agus A, Clément K, Sokol H
Published in: Gut, 2021, ISSN 1468-3288
Publisher: BMJ
DOI: 10.1136/gutjnl-2020-323071