Defining novel mechanisms critical for colorectal tumourigenesis

Project Information

COLGENES

Grant agreement ID: 715782

DOI 10.3030/715782

Project closed

EC signature date 3 February 2017

Start date 1 August 2017

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 618,00

EU contribution € 1 498 618,00

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Participation in the Open Research Data Pilot

Open Research Data Pilot

Publications

Peer reviewed articles (8)

Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis

Author(s): Victoria Gudiño 1 2 , Patrizia Cammareri 1 , Caroline V Billard 1 , Kevin B Myant 3
Published in: Cell Death and Disease, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-04177-7

A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer

Author(s): Jon Peñarando, Laura M. López-Sánchez, Rafael Mena, Silvia Guil-Luna, Francisco Conde, Vanessa Hernández, Marta Toledano, Victoria Gudiño, Michela Raponi, Caroline Billard, Carlos Villar, César Díaz, José Gómez-Barbadillo, Juan De la Haba-Rodríguez, Kevin Myant, Enrique Aranda, Antonio Rodríguez-Ariza
Published in: BMC Biology, Issue 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-017-0472-5

Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1

Author(s): Karen Dunbar, Asta Valanciute, Ana Lima, Paz Freile Vinuela, Thomas Jamieson, Vidya Rajasekaran, James Blackmur, Anna-Maria Ochocka-Fox, Alice Guazzelli, Patrizia Cammareri, Mark J. Arends, Owen J. Sansom, Kevin B. Myant, Susan M. Farrington, Malcolm G. Dunlop, Farhat V.N. Din
Published in: Cellular and Molecular Gastroenterology and Hepatology, 2020, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.09.010

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

Author(s): Victoria Gudiño 1 2 , Sebastian Öther-Gee Pohl 1 , Caroline V Billard 1 , Patrizia Cammareri 1 , Alfonso Bolado 1 , Stuart Aitken 3 4 , David Stevenson 5 , Adam E Hall 1 , Mark Agostino 6 7 , John Cassidy 8 , Colin Nixon 5 , Alex von Kriegsheim 1 , Paz Freile 1 3 4 , Linda Popplewell 9 , George Dickson 9 , Laura Murphy 4 , Ann Wheeler 4 , Malcolm Dunlop 1 3 4 , Fa
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22531-3

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Author(s): Adam E Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T Younger, Michela Raponi, Caroline V Billard, Alfonso Bolado Carrancio, Aslihan Bastem , Paz Freile, Fiona Haward, Ian R Adams, Javier F Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G Dunlop, Farhat V Din , Kevin B Myant
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30489-z

Alternative RNA splicing in tumour heterogeneity, plasticity and therapy

Author(s): Sebastian Öther-Gee Pohl 1 , Kevin B Myant 1
Published in: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Publisher: The Company of Biologists
DOI: 10.1242/dmm.049233

A RAC-GEF network critical for early intestinal tumourigenesis

Author(s): K A Pickering 1 , K Gilroy 1 , J W Cassidy 2 , S K Fey 1 3 , A K Najumudeen 1 , L B Zeiger 1 3 , D F Vincent 1 , D M Gay 1 , J Johansson 1 , R P Fordham 1 , B Miller 1 , W Clark 1 , A Hedley 1 , E B Unal 4 5 6 , C Kiel 4 , E McGhee 1 , L M Machesky 1 3 , C Nixon 1 , A E Johnsson 7 , M Bain 8 , D Strathdee 1 , S R van Hoof 9 10 , J P Medema 9 10 , K I Anderson
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20255-4

Be like water, my cells: cell plasticity and the art of transformation

Author(s): Patrizia Cammareri and Kevin Myant
Published in: Frontiers in Cell and Developmental Biology, Issue 2023 Oct 11:11:1272730, 2023, ISSN 2296-634X
Publisher: Frontiers

Non-peer reviewed articles (1)

COLGENES - Defining novel mechanisms critical for colorectal tumourigenesis

Author(s): Kevin Myant
Published in: Impact, Issue 2017/10, 2017, Page(s) 12-14, ISSN 2398-7073
Publisher: Science Impact Ltd
DOI: 10.21820/23987073.2017.10.12