Selective glycoimmuno-targeting for cancer therapy

Project Information

SweetAim

Grant agreement ID: 716220

DOI

10.3030/716220

Project closed

EC signature date 28 November 2016

Start date 1 December 2016

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 479 995,00

EU contribution

€ 1 479 995,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study

Author(s): Salam Bashir, Leopold K. Fezeu, Shani Leviatan Ben-Arye, Sharon Yehuda, Eliran Moshe Reuven, Fabien Szabo de Edelenyi, Imen Fellah-Hebia, Thierry Le Tourneau, Berthe Marie Imbert-Marcille, Emmanuel B. Drouet, Mathilde Touvier, Jean-Christian Roussel, Hai Yu, Xi Chen, Serge Hercberg, Emanuele Cozzi, Jean-Paul Soulillou, Pilar Galan, Vered Padler-Karavani
Published in: BMC Medicine, Issue 18/1, 2020, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01721-8

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Author(s): Senage T, Paul A, Le Tourneau T, Fellah-Hebia I, Vadori M, Bashir S, Galiñanes M, Bottio T, Gerosa G, Evangelista A, Badano LP, Nassi A, Costa C, Cesare G, Manji RA, Cueff de Monchy C, Piriou N, Capoulade R, Serfaty JM, Guimbretière G, Dantan E, Ruiz-Majoral A, Coste du Fou G, Leviatan Ben-Arye S, Govani L, Yehuda S, Bachar Abramovitch S, Amon R, Reuven EM, Atiya-Nasagi Y, Yu H, Iop L, Casós K,
Published in: NATURE MEDICINE, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-01682-w

Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer

Author(s): Ron Amon, Ronit Rosenfeld, Shahar Perlmutter, Oliver C. Grant, Sharon Yehuda, Aliza Borenstein-Katz, Ron Alcalay, Tal Marshanski, Hai Yu, Ron Diskin, Robert J. Woods, Xi Chen, Vered Padler-Karavani
Published in: Cancers, Issue 12/10, 2020, Page(s) 2824, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102824

Evolution of sialic acids: Implications in xenotransplant biology

Author(s): Anu Paul, Vered Padler-Karavani
Published in: Xenotransplantation, 2018, Page(s) e12424, ISSN 0908-665X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/xen.12424

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

Author(s): Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24333-y

A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen

Author(s): Ron Amon, Oliver C. Grant, Shani Leviatan Ben-Arye, Spandana Makeneni, Anita K. Nivedha, Tal Marshanski, Christoffer Norn, Hai Yu, John N. Glushka, Sarel J. Fleishman, Xi Chen, Robert J. Woods, Vered Padler-Karavani
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-29209-9

Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy

Author(s): Ron Amon, Shani Leviatan Ben-Arye, Limor Engler, Hai Yu, Noha Lim, Ludmilla Le Berre, Kristina M. Harris, Mario R. Ehlers, Stephen E. Gitelman, Xi Chen, Jean-Paul Soulillou, Vered Padler-Karavani
Published in: Oncotarget, Issue 8/68, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.23096

Glycan Microarray Reveal the Sweet Side of Cancer Vaccines

Author(s): Vered Padler-Karavani
Published in: Cell Chemical Biology, Issue 23/12, 2016, Page(s) 1446-1447, ISSN 2451-9456
Publisher: Elsevier Ltd.
DOI: 10.1016/j.chembiol.2016.12.002

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N- Acetylneuraminic Acid as a Host Adaptation

Author(s): Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings
Published in: mBio, Issue 10/3, 2019, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.00422-19

Microarray Analysis of Oligosaccharide-Mediated Multivalent Carbohydrate-Protein Interactions and Their Heterogeneity

Author(s): Madhuri Gade, Catherine Alex, Shani Leviatan Ben-Arye, João T. Monteiro, Sharon Yehuda, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri
Published in: ChemBioChem, Issue 19/11, 2018, Page(s) 1170-1177, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800037

Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy

Author(s): Eliran Moshe Reuven, Shani Leviatan Ben-Arye, Hai Yu, Roberto Duchi, Andrea Perota, Sophie Conchon, Shirley Bachar Abramovitch, Jean-Paul Soulillou, Cesare Galli, Xi Chen, Vered Padler-Karavani
Published in: ACS Nano, Issue 13/3, 2019, Page(s) 2936-2947, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b07241

Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies

Author(s): Salam Bashir, Shani Leviatan Ben Arye, Eliran Moshe Reuven, Hai Yu, Cristina Costa, Manuel Galiñanes, Tomaso Bottio, Xi Chen, Vered Padler-Karavani
Published in: Bioconjugate Chemistry, Issue 30/1, 2018, Page(s) 161-168, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.8b00817

Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies

Author(s): Shani Leviatan Ben-Arye, Christoph Schneider, Hai Yu, Salam Bashir, Xi Chen, Stephan von Gunten, Vered Padler-Karavani
Published in: Bioconjugate Chemistry, Issue 30/5, 2019, Page(s) 1565-1574, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00273

Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies

Author(s): Aliza Borenstein-Katz, Shira Warszawski, Ron Amon, Maayan Eilon, Hadas Cohen-Dvashi, Shani Leviatan Ben-Arye, Nova Tasnima, Hai Yu, Xi Chen, Vered Padler-Karavani, Sarel Jacob Fleishman, Ron Diskin
Published in: JOURNAL OF MOLECULAR BIOLOGY, 2021, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167099

Editorial: Human Antibodies Against the Dietary Non-human Neu5Gc-Carrying Glycans in Normal and Pathologic States

Author(s): Jean-Paul Soulillou, Vered Padler-Karavani
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01589