Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Project Information

ALLERGUT

Grant agreement ID: 716718

DOI

10.3030/716718

Project closed

EC signature date 13 June 2017

Start date 1 July 2017

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 175,00

EU contribution

€ 1 498 175,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages

Author(s): Ann-Marie Maier; Karsten Huth; Francesca Alessandrini; Fiona Henkel; Benjamin Schnautz; Anela Arifovic; Fabien Riols; Mark Haid; Anja Koegler; Katrin Sameith; Carsten B. Schmidt-Weber; Julia Esser-von-Bieren; Caspar Ohnmacht
Published in: Frontiers in immunology, vol. 14, pp. 1157373, Issue 1, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1157373

Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation

Author(s): Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.1101/2021.09.20.461064

Tissue niches formed by intestinal mesenchymal stromal cells in mucosal homeostasis and immunity.

Author(s): Maria Pasztoi; Caspar Ohnmacht
Published in: MDPI, Issue 1, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095181

TGF-β specifies T _FH versus T _H 17 cell fates in murine CD4 ⁺ T cells through c-Maf

Author(s): Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T. Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T. Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefa
Published in: Science Immunology, Issue 9, 2024, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.add4818

Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity

Author(s): Anna-Lena Geiselhöringer, Daphne Kolland, Arisha Johanna Patt, Linda Hammann, Amelie Köhler, Luisa Kreft, Nina Wichmann, Miriam Hils, Christiane Ruedl, Marc Riemann, Tilo Biedermann, David Anz, Andreas Diefenbach, David Voehringer, Carsten B. Schmidt-Weber, Tobias Straub, Maria Pasztoi, Caspar Ohnmacht
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53112-9

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism.

Author(s): Leonie Zeitler; Alessandra Fiore; Claudia Meyer; Marion Russier; Gaia Zanella; Sabine Suppmann; Marco Gargaro; Sachdev S. Sidhu; Somasekar Seshagiri; Caspar Ohnmacht; Thomas Köcher; Francesca Fallarino; Andreas Linkermann; Peter J. Murray
Published in: eLife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.64806

Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report

Author(s): Emiel P. C. van der Vorst; Manuela Mandl; Madeleine Müller; Carlos Neideck; Yvonne Jansen; Michael Hristov; Selin Gencer; Linsey J. F. Peters; Svenja Meiler; Micha Feld; Anna-Lena Geiselhöringer; Renske J. de Jong; Caspar Ohnmacht; Heidi Noels; Oliver Soehnlein; Oliver Soehnlein; Maik Drechsler; Christian Weber; Christian Weber; Yvonne Döring
Published in: Arteriosclerosis Thrombosis and Vascular Biology, 39(4), 685 - 693. LIPPINCOTT WILLIAMS & WILKINS, Issue 2, 2019, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.312386

RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells

Author(s): Nico Andreas, Maria Potthast, Anna-Lena Geiselhöringer, Garima Garg, Renske de Jong, Julia Riewaldt, Dennis Russkamp, Marc Riemann, Jean-Philippe Girard, Simon Blank, Karsten Kretschmer, Carsten Schmidt-Weber, Thomas Korn, Falk Weih, Caspar Ohnmacht
Published in: The Journal of Immunology, Issue 203/10, 2019, Page(s) 2602-2613, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1801530

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins

Author(s): Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Published in: The Journal of Immunology, Issue 203/6, 2019, Page(s) 1417-1427, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900468

Defining Dysbiosis in Inflammatory Bowel Disease

Author(s): Renske J. de Jong, Caspar Ohnmacht
Published in: Immunity, Issue 50/1, 2019, Page(s) 8-10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.12.028

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV

Author(s): Roland Immler, Katrin Nussbaumer, Axel Doerner, Omar El Bounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A. Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D. Marth, David Frommhold, Markus Sperandio
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2319057121

A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria

Author(s): Luisa Kreft; Aloys Schepers; Miriam Hils; Kyra Swiontek; Andrew Flatley; Robert Janowski; Mohammadali Khan Mirzaei; Michael Dittmar; Neera Chakrapani; Mahesh S. Desai; Stefanie Eyerich; Li Deng; Dierk Niessing; Konrad Fischer; Regina Feederle; Simon Blank; Carsten B. Schmidt-Weber; Christiane Hilger; Tilo Biedermann; Caspar Ohnmacht
Published in: Front. Immunol. 13:958952 (2022), Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.958952

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Author(s): Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. S
Published in: Nature Communications, Issue 12, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20659-2

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4

Author(s): Miriam Hils, Nils Hoffard, Caterina Iuliano, Luisa Kreft, Neera Chakrapani, Kyra Swiontek, Konrad Fischer, Bernadette Eberlein, Martin Köberle, Jörg Fischer, Christiane Hilger, Caspar Ohnmacht, Susanne Kaesler, Florian Wölbing, Tilo Biedermann
Published in: Journal of Allergy and Clinical Immunology, Issue 153, 2024, Page(s) 1050-1062.e6, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2023.12.003

Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies

Author(s): Luisa Kreft, Christian Hoffmann, Caspar Ohnmacht
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: International Union of Immunological Societies
DOI: 10.3389/fimmu.2020.01853

NF-κB in control of regulatory T cell development, identity, and function

Author(s): Hoevelmeyer, N.; Schmidt-Supprian, M.; Ohnmacht, C.
Published in: J. Mol. Med. 100, 985-995 (2022), Issue 1, 2022, Page(s) 985-995, ISSN 0946-2716
Publisher: Springer Verlag
DOI: 10.1007/s00109-022-02215-1

The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets

Author(s): Amelie Köhler, Anna-Lena Geiselhöringer, Daphne Kolland, Luisa Kreft, Nina Wichmann, Miriam Hils, Maria Pasztoi, Elena Zurkowski, Johannes Vogt, Tanja Kübelbeck, Tilo Biedermann, Ingo Schmitz, Wiebke Hansen, Daniela Kramer, Matthias M. Gaida, Carsten B. Schmidt-Weber, Nadine Hoevelmeyer, Caspar Ohnmacht
Published in: Mucosal Immunology, Issue 17, 2024, Page(s) 673-691, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.04.002