Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Informazioni relative al progetto

ALLERGUT

ID dell’accordo di sovvenzione: 716718

DOI

10.3030/716718

Progetto chiuso

Data della firma CE 13 Giugno 2017

Data di avvio 1 Luglio 2017

Data di completamento 30 Aprile 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 498 175,00

Contributo UE

€ 1 498 175,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages

Autori: Ann-Marie Maier; Karsten Huth; Francesca Alessandrini; Fiona Henkel; Benjamin Schnautz; Anela Arifovic; Fabien Riols; Mark Haid; Anja Koegler; Katrin Sameith; Carsten B. Schmidt-Weber; Julia Esser-von-Bieren; Caspar Ohnmacht
Pubblicato in: Frontiers in immunology, vol. 14, pp. 1157373, Numero 1, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1157373

Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation

Autori: Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.1101/2021.09.20.461064

Tissue niches formed by intestinal mesenchymal stromal cells in mucosal homeostasis and immunity.

Autori: Maria Pasztoi; Caspar Ohnmacht
Pubblicato in: MDPI, Numero 1, 2022, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23095181

TGF-β specifies T _FH versus T _H 17 cell fates in murine CD4 ⁺ T cells through c-Maf

Autori: Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T. Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T. Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefa
Pubblicato in: Science Immunology, Numero 9, 2024, ISSN 2470-9468
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.add4818

Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity

Autori: Anna-Lena Geiselhöringer, Daphne Kolland, Arisha Johanna Patt, Linda Hammann, Amelie Köhler, Luisa Kreft, Nina Wichmann, Miriam Hils, Christiane Ruedl, Marc Riemann, Tilo Biedermann, David Anz, Andreas Diefenbach, David Voehringer, Carsten B. Schmidt-Weber, Tobias Straub, Maria Pasztoi, Caspar Ohnmacht
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53112-9

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism.

Autori: Leonie Zeitler; Alessandra Fiore; Claudia Meyer; Marion Russier; Gaia Zanella; Sabine Suppmann; Marco Gargaro; Sachdev S. Sidhu; Somasekar Seshagiri; Caspar Ohnmacht; Thomas Köcher; Francesca Fallarino; Andreas Linkermann; Peter J. Murray
Pubblicato in: eLife, Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.64806

Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report

Autori: Emiel P. C. van der Vorst; Manuela Mandl; Madeleine Müller; Carlos Neideck; Yvonne Jansen; Michael Hristov; Selin Gencer; Linsey J. F. Peters; Svenja Meiler; Micha Feld; Anna-Lena Geiselhöringer; Renske J. de Jong; Caspar Ohnmacht; Heidi Noels; Oliver Soehnlein; Oliver Soehnlein; Maik Drechsler; Christian Weber; Christian Weber; Yvonne Döring
Pubblicato in: Arteriosclerosis Thrombosis and Vascular Biology, 39(4), 685 - 693. LIPPINCOTT WILLIAMS & WILKINS, Numero 2, 2019, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.312386

RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells

Autori: Nico Andreas, Maria Potthast, Anna-Lena Geiselhöringer, Garima Garg, Renske de Jong, Julia Riewaldt, Dennis Russkamp, Marc Riemann, Jean-Philippe Girard, Simon Blank, Karsten Kretschmer, Carsten Schmidt-Weber, Thomas Korn, Falk Weih, Caspar Ohnmacht
Pubblicato in: The Journal of Immunology, Numero 203/10, 2019, Pagina/e 2602-2613, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1801530

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins

Autori: Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Pubblicato in: The Journal of Immunology, Numero 203/6, 2019, Pagina/e 1417-1427, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1900468

Defining Dysbiosis in Inflammatory Bowel Disease

Autori: Renske J. de Jong, Caspar Ohnmacht
Pubblicato in: Immunity, Numero 50/1, 2019, Pagina/e 8-10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2018.12.028

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV

Autori: Roland Immler, Katrin Nussbaumer, Axel Doerner, Omar El Bounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A. Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D. Marth, David Frommhold, Markus Sperandio
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2319057121

A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria

Autori: Luisa Kreft; Aloys Schepers; Miriam Hils; Kyra Swiontek; Andrew Flatley; Robert Janowski; Mohammadali Khan Mirzaei; Michael Dittmar; Neera Chakrapani; Mahesh S. Desai; Stefanie Eyerich; Li Deng; Dierk Niessing; Konrad Fischer; Regina Feederle; Simon Blank; Carsten B. Schmidt-Weber; Christiane Hilger; Tilo Biedermann; Caspar Ohnmacht
Pubblicato in: Front. Immunol. 13:958952 (2022), Numero 1, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.958952

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Autori: Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. S
Pubblicato in: Nature Communications, Numero 12, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20659-2

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4

Autori: Miriam Hils, Nils Hoffard, Caterina Iuliano, Luisa Kreft, Neera Chakrapani, Kyra Swiontek, Konrad Fischer, Bernadette Eberlein, Martin Köberle, Jörg Fischer, Christiane Hilger, Caspar Ohnmacht, Susanne Kaesler, Florian Wölbing, Tilo Biedermann
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 153, 2024, Pagina/e 1050-1062.e6, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2023.12.003

Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies

Autori: Luisa Kreft, Christian Hoffmann, Caspar Ohnmacht
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: International Union of Immunological Societies
DOI: 10.3389/fimmu.2020.01853

NF-κB in control of regulatory T cell development, identity, and function

Autori: Hoevelmeyer, N.; Schmidt-Supprian, M.; Ohnmacht, C.
Pubblicato in: J. Mol. Med. 100, 985-995 (2022), Numero 1, 2022, Pagina/e 985-995, ISSN 0946-2716
Editore: Springer Verlag
DOI: 10.1007/s00109-022-02215-1

The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets

Autori: Amelie Köhler, Anna-Lena Geiselhöringer, Daphne Kolland, Luisa Kreft, Nina Wichmann, Miriam Hils, Maria Pasztoi, Elena Zurkowski, Johannes Vogt, Tanja Kübelbeck, Tilo Biedermann, Ingo Schmitz, Wiebke Hansen, Daniela Kramer, Matthias M. Gaida, Carsten B. Schmidt-Weber, Nadine Hoevelmeyer, Caspar Ohnmacht
Pubblicato in: Mucosal Immunology, Numero 17, 2024, Pagina/e 673-691, ISSN 1933-0219
Editore: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.04.002