Objective
Pluripotent Stem cells (PSCs) can give rise to all differentiated cells of the body and the germ line, which makes them conceptually fascinating and a valuable tool for regenerative medicine. Mouse PSCs are devoid of any developmental restriction partly thanks to their “open” chromatin, characterised by remarkably low levels of repressive epigenetic modifications. Metabolism is a key feature that can be adjusted to meet the cell’s needs, and that has the potential to feedback on transcription and epigenetics. How metabolism is regulated in PSCs and whether this is important for their biology remains largely unknown.
We recently found a new molecular mechanism by which energy production is coupled to pluripotency. Here we propose to deepen our understanding of how metabolism, epigenetics and transcription are reciprocally regulated for the self-renewal and differentiation of PSCs. To gain insights into how metabolism is dynamically regulated in concert with the transcriptome and epigenome, we will also use somatic cell reprogramming into PSCs, a process in which both the metabolic and epigenetic profiles must be reset to match those of PSCs. Moreover, taking advantage of the recent generation of novel human PSCs sharing most of the transcriptional and epigenetic features found in naïve mouse PSCs, we will explore how metabolic regulatory mechanisms key for the generation and maintenance of pluripotency are conserved throughout evolution. Altogether, large-scale transcriptional, epigenetic and metabolic profiling of PSCs, combined with cutting edge technologies for their generation, expansion and genetic manipulation, will give us the unprecedented opportunity to build a comprehensive computational model of the metabolic network in PSCs, and to study how gene transcription and metabolism regulate each other.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
35122 Padova
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.