Dissecting the crosstalk between metabolism and transcriptional regulation in pluripotent stem cells.

Project Information

MetEpiStem

Grant agreement ID: 716910

DOI

10.3030/716910

Project closed

EC signature date 9 March 2017

Start date 1 October 2017

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 232,00

EU contribution

€ 1 498 232,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern.

Author(s): Frasson I, Diamante L, Zangrossi M, Carbognin E, Dalla Pietà A, Penna A, Rosato A, Verin R, Torrigiani F, Salata C, Dizanzo MP, Vaccaro L, Cacchiarelli D, Richter SN, Montagner M, Martello G.
Published in: Journal of Molecular Cell Biology, 2024, Page(s) mjae004, ISSN 1759-4685
Publisher: Oxford University Press
DOI: 10.1093/jmcb/mjae004

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Author(s): Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S
Published in: Nature Cell Biology, Issue 24, 2022, Page(s) 168-180, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00843-w

3D ECM-rich environment sustains the identity of naive human iPSCs.

Author(s): Cesare E, Urciuolo A, Stuart HT, Torchio E, Gesualdo A, Laterza C, Gagliano O, Martewicz S, Cui M, Manfredi A, Di Filippo L, Sabatelli P, Squarzoni S, Zorzan I, Betto RM, Martello G, Cacchiarelli D, Luni C, Elvassore N
Published in: Cell Stem Cell, Issue 29, 2022, Page(s) 1703-1717, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.11.011

Metabolic control of DNA methylation in naive pluripotent cells

Author(s): Betto RM, Diamante L, Perrera V, Audano M, Rapelli S, Lauria A, Incarnato D, Arboit M, Pedretti S, Rigoni G, Guerineau V, Touboul D, Stirparo GG, Lohoff T, Boroviak T, Grumati P, Soriano ME, Nichols J, Mitro N, Oliviero S, Martello G.
Published in: Nature Genetics, Issue 53, 2021, Page(s) 215-229, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00770-2

PsiNorm: a scalable normalization for single-cell RNA-seq data.

Author(s): Borella M, Martello G, Risso D, Romualdi C.
Published in: Bioinformatics, Issue 38, 2021, Page(s) 164-172, ISSN 1367-4811
Publisher: Oxford Academic
DOI: 10.1093/bioinformatics/btab641

BrewerIX enables allelic expression analysis of imprinted and X-linked genes from bulk and single-cell transcriptomes.

Author(s): Martini P, Sales G, Diamante L, Perrera V, Colantuono C, Riccardo S, Cacchiarelli D, Romualdi C, Martello G.
Published in: Communications Biology, Issue 5, 2022, Page(s) 146, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-03087-4

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

Author(s): Dinarello A, Betto RM, Diamante L, Tesoriere A, Ghirardo R, Cioccarelli C, Meneghetti G, Peron M, Laquatra C, Tiso N, Martello G, Argenton F.
Published in: Cell Death Discovery, Issue 9, 2023, Page(s) 226, ISSN 2058-7716
Publisher: Springer Nature
DOI: 10.1038/s41420-023-01507-w

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.

Author(s): Peron M, Dinarello A, Meneghetti G, Martorano L, Betto RM, Facchinello N, Tesoriere A, Tiso N, Martello G, Argenton F.
Published in: Development, Issue 148, 2021, Page(s) dev199477, ISSN 1477-9129
Publisher: The Company of Biologists
DOI: 10.1242/dev.199477

Metabolic regulation in pluripotent stem cells

Author(s): Diamante L, Martello G.
Published in: Current Opinion in Genetics & Development, Issue 75, 2022, Page(s) 101923, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2022.101923

Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics

Author(s): Stefano Giulitti, Marco Pellegrini, Irene Zorzan, Paolo Martini, Onelia Gagliano, Margherita Mutarelli, Michael Johannes Ziller, Davide Cacchiarelli, Chiara Romualdi, Nicola Elvassore, Graziano Martello
Published in: Nature Cell Biology, Issue 21/2, 2019, Page(s) 275-286, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0254-5

A common molecular logic determines embryonic stem cell self‐renewal and reprogramming

Author(s): Sara‐Jane Dunn, Meng Amy Li, Elena Carbognin, Austin Smith, Graziano Martello
Published in: The EMBO Journal, Issue 38/1, 2019, Page(s) e100003, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100003

How Does Reprogramming to Pluripotency Affect Genomic Imprinting?

Author(s): Valentina Perrera, Graziano Martello
Published in: Frontiers in Cell and Developmental Biology, Issue 7, 2019, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2019.00076

The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs

Author(s): Irene Zorzan, Marco Pellegrini, Mattia Arboit, Danny Incarnato, Mara Maldotti, Mattia Forcato, Guidantonio Malagoli Tagliazucchi, Elena Carbognin, Marco Montagner, Salvatore Oliviero, Graziano Martello
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16205-9

Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation

Author(s): Zorzan I, Betto RM, Rossignoli G, Arboit M, Drusin A, Corridori C, Martini P, Martello G.
Published in: EMBO reports, Issue 24, 2023, Page(s) e55235, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.15252/embr.202255235

Esrrb guides naive pluripotent cells through the formative transcriptional programme.

Author(s): Carbognin E, Carlini V, Panariello F, Chieregato M, Guerzoni E, Benvegnù D, Perrera V, Malucelli C, Cesana M, Grimaldi A, Mutarelli M, Carissimo A, Tannenbaum E, Kugler H, Hackett JA, Cacchiarelli D, Martello G
Published in: Nature Cell Biology, Issue 25, 2023, Page(s) 643-657, ISSN 1476-4679
Publisher: springer Nature
DOI: 10.1038/s41556-023-01131-x

STAT3-dependent long non-coding RNA Lncenc1 contributes to mouse ES cells pluripotency via stabilizing K mRNA.

Author(s): Monteleone E, Corrieri P, Provero P, Viavattene D, Pulvirenti L, Raggi L, Carbognin E, Bianchi ME, Martello G, Oliviero S, Pandolfi PP, Poli V.
Published in: Briefings in Functional Genomics, 2023, Page(s) elad045, ISSN 2041-2657
Publisher: Oxford University Press
DOI: 10.1093/bfgp/elad045

Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.

Author(s): Ferlazzo GM, Gambetta AM, Amato S, Cannizzaro N, Angiolillo S, Arboit M, Diamante L, Carbognin E, Romani P, La Torre F, Galimberti E, Pflug F, Luoni M, Giannelli S, Pepe G, Capocci L, Di Pardo A, Vanzani P, Zennaro L, Broccoli V, Leeb M, Moro E, Maglione V, Martello G.
Published in: Nature Communications, Issue 14, 2023, Page(s) 3962, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39552-9

Book chapters (1)

Using Microfluidics to Generate Human Naïve and Primed Pluripotent Stem Cells

Author(s): Zorzan I, Gagliano O, Elvassore N, Martello G
Published in: Methods in Molecular Biology, Issue 2416, 2021, Page(s) 53-71, ISBN 978-1-0716-1907-0
Publisher: Humana
DOI: 10.1007/978-1-0716-1908-7_5

Other (1)

Mitochondrial STAT3 regulates proliferation of tissue stem cells

Author(s): Margherita Peron, Giacomo Meneghetti, Alberto Dinarello, Laura Martorano, Riccardo M. Betto, Nicola Facchinello, Natascia Tiso, Graziano Martello, Francesco Argenton
Published in: www.biorXiv.org, 2020
Publisher: Cold Spring Harbor Press
DOI: 10.1101/2020.07.17.208264

Intellectual Property Rights

Patent (1)

niPSCs DERIVED FROM SOMATIC CELLS

Application/Publication number: 20 19054718
Date: 2019-06-06
Applicant(s): UNIVERSITA DEGLI STUDI DI PADOVA