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Translational Research Network in Prostate Cancer

Descripción del proyecto

Red de formación en investigación sobre el cáncer de próstata incurable

El cáncer de próstata (CP) es un problema de salud mundial, y el tratamiento en casos de recaída de cáncer resistente tras una terapia hormonal previa sigue siendo un reto. El proyecto TransPot, financiado por la iniciativa Marie Skłodowska-Curie Actions, constituye una red de formación en investigación diseñada para estudiar el PC incurable. El objetivo de la red es formar a un grupo de jóvenes investigadores para que se conviertan en científicos traslacionales en biología del cáncer, descubrimiento de biomarcadores y desarrollo terapéutico. Entre los objetivos se incluyen comprender mejor el CP resistente al tratamiento, identificar nuevas estrategias para superar la resistencia, desarrollar nuevas pruebas para predecir la respuesta del cáncer al tratamiento y definir herramientas holísticas para pacientes individuales con CP resistente al tratamiento.

Objetivo

The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC).

The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatment of lethal PC, aimed to (i) provide important insights into molecular mechanisms driving treatment resistant PC including castrate-resistant PC (CRPC), (ii) identify novel therapeutic targets, (iii) develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iv) provide superior, clinically relevant tools and biomarker signatures for personalising and optimising CRPC therapy.

Our research program is built on network-wide, state-of-the-art cancer biology-based mechanistic research integrated with a systems medicine approach:

1. Cancer biology-based mechanistic research incorporating a comprehensive range of model systems incorporating unique, pre-clinical and clinical resources and distinct phenotypic high content screen platforms.

2. A systems medicine approach with mathematical modelling to develop novel predictive/prognostic tools.

3. Centres of excellence in surgery, oncology and clinical trials, comprising clinical infrastructure and essential resources whereby candidate therapeutic targets and predictive/prognostic tools can be comprehensively evaluated, including accessing bio-repository resources.

We will train young scientists to apply multiple ‘omics’ technologies and approaches in model systems and systems biology to answer important clinically-relevant questions. Advances achieved will facilitate personalized targeted-medicine in treating lethal PC, and will impact beyond the scientific community by improving the well-being of advanced PC patients.

Coordinador

UNIVERSITY OF GLASGOW
Aportación neta de la UEn
€ 273 287,88
Dirección
UNIVERSITY AVENUE
G12 8QQ Glasgow
Reino Unido

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Región
Scotland West Central Scotland Glasgow City
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 273 287,88

Participantes (10)

Socios (6)