Multimodal, Functional Bio-Photonic Imaging

Deliverables

Websites, patent fillings, videos etc. (1)

Websites (external and internal for data sharing)

Websites (external and internal for data sharing)

Documents, reports (4)

Compact broadband Ti:sapphire laser technology incorporating new pump sources

Compact broadband Ti:sapphire laser technology incorporating new pump sources, to be completed in collaboration with HighQ/DTU

Progress Report

Progress Report

Tissue classification technology based on OCT and its combination with US

Tissue classification technology based on OCT and its combination with US

Mid Term report

The mid term review meeting may take place between month 18-26

Other (1)

3 joint workshops (WS1, WS2, WS3, WS4)

4 joint workshops: (WS1, WS2, WS4) for 2 ECTS each and WS3 (bioethics) All workshops are joint efforts between TUE, MUW, and TUM

Publications

Peer reviewed articles (24)

Influence of pump beam shaping and noise on performance of a direct diode-pumped ultrafast Ti:sapphire laser

Author(s): Muhammad Tahir jamal, Anders Kragh Hansen, Mahmoud Tawfieq, Peter Eskil Andersen, Ole Bjarlin Jensen
Published in: Optics Express, Issue 28/21, 2020, Page(s) 31754, ISSN 1094-4087
DOI: 10.1364/oe.404968

Optical imaging of surface chemistry and dynamics in confinement

Author(s): Carlos Macias-Romero, Igor Nahalka, Halil I. Okur, Sylvie Roke
Published in: Science, Issue 357/6353, 2017, Page(s) 784-788, ISSN 0036-8075
DOI: 10.1126/science.aal4346

Interaction of Oil and Lipids in Freestanding Lipid Bilayer Membranes Studied with Label-Free High-Throughput Wide-Field Second-Harmonic Microscopy

Author(s): Orly B. Tarun, Maksim Yu Eremchev, Sylvie Roke
Published in: Langmuir, Issue 34/38, 2018, Page(s) 11305-11310, ISSN 0743-7463
DOI: 10.1021/acs.langmuir.8b01790

Imaging of the human tympanic membrane by endoscopic optical coherence tomography

Author(s): Martin Schindler, Lars Kirsten, Joseph Morgenstern, Jonas Golde, Mikael Erkkilä, Julia Walther, Max Kemper, Matthias Bornitz, Marcus Neudert, Thomas Zahnert, Edmund Koch
Published in: Current Directions in Biomedical Engineering, Issue 4/1, 2018, Page(s) 305-308, ISSN 2364-5504
DOI: 10.1515/cdbme-2018-0074

Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane

Author(s): Lars Kirsten, Martin Schindler, Joseph Morgenstern, Mikael Timo Erkkilä, Jonas Golde, Julia Walther, Pascal Rottmann, Max Kemper, Matthias Bornitz, Marcus Neudert, Thomas Zahnert, Edmund Koch
Published in: Journal of Biomedical Optics, Issue 24/03, 2019, Page(s) 1, ISSN 1083-3668
DOI: 10.1117/1.JBO.24.3.031017

Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

Author(s): Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael Erkkilä, Fabian Placzek, Jeremias Püls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, Jürgen Popp, Marco Andreana, Angelika Unterhuber
Published in: Applied Sciences, Issue 8/12, 2018, Page(s) 2371, ISSN 2076-3417
DOI: 10.3390/app8122371

Widefield fluorescence lifetime imaging of protoporphyrin IX for fluorescence-guided neurosurgery: an ex vivo feasibility study

Author(s): Mikael T. Erkkilä, Bianca Bauer, Nancy Hecker-Denschlag, Maria J. Madera Medina, Rainer A. Leitgeb, Angelika Unterhuber, Johanna Gesperger, Thomas Roetzer, Christoph Hauger, Wolfgang Drexler, Georg Widhalm, Marco Andreana
Published in: Journal of Biophotonics, 2019, ISSN 1864-063X
DOI: 10.1002/jbio.201800378

Coherent combining of high brightness tapered amplifiers for efficient non-linear conversion

Author(s): P. Albrodt, M. T. Jamal, A. K. Hansen, O. B. Jensen, G. Blume, K. Paschke, P. Crump, P. Georges, G. Lucas-Leclin
Published in: Optics Express, Issue 27/2, 2019, Page(s) 928, ISSN 1094-4087
DOI: 10.1364/oe.27.000928

Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe

Author(s): Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Çağlar Ataman
Published in: Journal of Biophotonics, Issue 2019-01-16, 2019, Page(s) e201800382, ISSN 1864-063X
DOI: 10.1002/jbio.201800382

Ensemble of Deep Convolutional Neural Networks for Classification of Early Barrett’s Neoplasia Using Volumetric Laser Endomicroscopy

Author(s): Roger Fonollà, Thom Scheeve, Maarten R. Struyvenberg, Wouter L. Curvers, Albert J. de Groof, Fons van der Sommen, Erik J. Schoon, Jacques J.G.H.M. Bergman, Peter H.N. de With
Published in: Applied Sciences, Issue 9/11, 2019, Page(s) 2183, ISSN 2076-3417
DOI: 10.3390/app9112183

Line Scan Raman Microspectroscopy for Label-Free Diagnosis of Human Pituitary Biopsies

Author(s): Daniela Bovenkamp, Alexander Micko, Jeremias Püls, Fabian Placzek, Romana Höftberger, Greisa Vila, Rainer Leitgeb, Wolfgang Drexler, Marco Andreana, Stefan Wolfsberger, Angelika Unterhuber
Published in: Molecules, Issue 24/19, 2019, Page(s) 3577, ISSN 1420-3049
DOI: 10.3390/molecules24193577

Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions

Author(s): Orly B. Tarun, Maksim Yu. Eremchev, Aleksandra Radenovic, Sylvie Roke
Published in: Nano Letters, 2019, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.9b02024

En face optical coherence tomography: a technology review [Invited]

Author(s): R. A. Leitgeb
Published in: Biomedical Optics Express, Issue 10/5, 2019, Page(s) 2177, ISSN 2156-7085
DOI: 10.1364/BOE.10.002177

Capsule optoacoustic endoscopy for esophageal imaging

Author(s): Hailong He, Antonios Stylogiannis, Parastoo Afshari, Tobias Wiedemann, Katja Steiger, Andreas Buehler, Christian Zakian, Vasilis Ntziachristos
Published in: Journal of Biophotonics, Issue 12/10, 2019, ISSN 1864-063X
DOI: 10.1002/jbio.201800439

Peculiarities of second harmonic generation with chirped femtosecond pulses at high conversion efficiency

Author(s): Pierre-Marc Dansette, Raimundas Burokas, Laurynas Veselis, Audrius Zaukevičius, Andrejus Michailovas, Nerijus Rusteika
Published in: Optics Communications, Issue 455, 2020, Page(s) 124462, ISSN 0030-4018
DOI: 10.1016/j.optcom.2019.124462

Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Author(s): Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo González-Cerdas, Mikael T. Erkkilä, Patrick Stein, Çağlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie
Published in: The Analyst, 2020, ISSN 0003-2654
DOI: 10.1039/c9an01911a

Surgical microscope with integrated fluorescence lifetime imaging for 5-aminolevulinic acid fluorescence-guided neurosurgery

Author(s): Mikael T. Erkkilä, David Reichert, Nancy Hecker-Denschlag, Marco Wilzbach, Christoph Hauger, Rainer A. Leitgeb, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Georg Widhalm, Wolfgang Drexler, Angelika Unterhuber, Marco Andreana
Published in: Journal of Biomedical Optics, Issue 25/07, 2020, Page(s) 1, ISSN 1083-3668
DOI: 10.1117/1.jbo.25.7.071202

Towards real-time wide-field fluorescence lifetime imaging of 5-ALA labeled brain tumors with multi-tap CMOS cameras

Author(s): David Reichert, Mikael T. Erkkilä, Gerhard Holst, Nancy Hecker-Denschlag, Marco Wilzbach, Christoph Hauger, Wolfgang Drexler, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Angelika Unterhuber, Georg Widhalm, Rainer A. Leitgeb, Marco Andreana
Published in: Biomedical Optics Express, Issue 11/3, 2020, Page(s) 1598, ISSN 2156-7085
DOI: 10.1364/boe.382817

Selecting optimal spectral bands for improved detection of autofluorescent biomarkers in multiphoton microscopy

Author(s): Björn-Ole Meyer, M. Pilar J. Stella, Bjørn Holst, Boye S. Nielsen, Kim Holmstrøm, Peter E. Andersen, Dominik Marti
Published in: Journal of Biomedical Optics, Issue 25/07, 2020, Page(s) 1, ISSN 1083-3668
DOI: 10.1117/1.jbo.25.7.071206

Fusion of augmented reality imaging with the endoscopic view for endonasal skull base surgery; a novel application for surgical navigation based on intraoperative cone beam computed tomography and optical tracking

Author(s): Marco Lai, Simon Skyrman, Caifeng Shan, Drazenko Babic, Robert Homan, Erik Edström, Oscar Persson, Gustav Burström, Adrian Elmi-Terander, Benno H. W. Hendriks, Peter H. N. de With
Published in: PLOS ONE, Issue 15/1, 2020, Page(s) e0227312, ISSN 1932-6203
DOI: 10.1371/journal.pone.0227312

Imaging the Heterogeneity of the Oxygen Evolution Reaction on Gold Electrodes Operando: Activity is Highly Local

Author(s): Gregor Zwaschka, Igor Nahalka, Arianna Marchioro, Yujin Tong, Sylvie Roke, R. Kramer Campen
Published in: ACS Catalysis, Issue 10/11, 2020, Page(s) 6084-6093, ISSN 2155-5435
DOI: 10.1021/acscatal.0c01177

A CNN CADx System for Multimodal Classification of Colorectal Polyps Combining WL, BLI, and LCI Modalities

Author(s): Roger Fonollà, Quirine E. W. van der Zander, Ramon M. Schreuder, Ad A. M. Masclee, Erik J. Schoon, Fons van der Sommen, Peter H. N. de With
Published in: Applied Sciences, Issue 10/15, 2020, Page(s) 5040, ISSN 2076-3417
DOI: 10.3390/app10155040

Prospective development and validation of a volumetric laser endomicroscopy computer algorithm for detection of Barrett’s neoplasia

Author(s): M.R. Struyvenberg, A.J. de Groof, R. Fonollà, F. van der Sommen, P.H.N. de With, E.J. Schoon, B.L.A.M. Weusten, C.L. Leggett, A. Kahn, A.J. Trindade, E.K. Ganguly, Vani J.A. Konda, C.J. Lightdale, D.K. Pleskow, Amrita Sethi, M.S. Smith, M.B. Wallace, H.C. Wolfsen, G.J. Tearney, S.L. Meijer, M. Vieth, R. Pouw, W.L. Curvers, J.J. Bergman
Published in: Gastrointestinal Endoscopy, 2020, ISSN 0016-5107
DOI: 10.1016/j.gie.2020.07.052

Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope

Author(s): Lara M. Wurster, Simon Kretschmer, Jan Jäger, Fabian Placzek, Laurin Ginner, Wolfgang Drexler, Çağlar Ataman, Rainer A. Leitgeb, Hans Zappe
Published in: Journal of Biomedical Optics, Issue 25/03, 2020, Page(s) 1, ISSN 1083-3668
DOI: 10.1117/1.jbo.25.3.032003

Non-peer reviewed articles (2)

Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

Author(s): Lars Kirsten, Simon Baumgärtner, Mikael Timo Erkkilä, Jonas Golde, Max Kemper, Thomas Stoppe, Matthias Bornitz, Marcus Neudert, Thomas Zahnert, Edmund Koch
Published in: Current Directions in Biomedical Engineering, Issue 2/1, 2016, ISSN 2364-5504
DOI: 10.1515/cdbme-2016-0098

Functional and morphological imaging of the human tympanic membrane with endoscopic optical coherence tomography

Author(s): Lars Kirsten, Joseph Morgenstern, Mikael Timo Erkkilä, Martin Schindler, Jonas Golde, Julia Walther, Max Kemper, Thomas Stoppe, Matthias Bornitz, Marcus Neudert, Thomas Zahnert, Edmund Koch
Published in: Current Directions in Biomedical Engineering, Issue 3/2, 2017, ISSN 2364-5504
DOI: 10.1515/cdbme-2017-0021

Conference proceedings (11)

Feasibility of Colonic Polyp classification with CNN based on Blue Light and Linked Color Imaging

Author(s): Fonollà, Roger van der Sommen, Fons Schreuder, R.M. Schoon, E.J. de With, P.H.N.
Published in: Symposium on information theory and signal processing in the benelux, Issue 39, 2018, Page(s) 85

Widely tunable femtosecond non-collinear optical parametric oscillator (NOPO) in VIS

Author(s): Yuliya Binhammer, Thomas Binhammer, Fabian Placzek, Bernhard Kreipe, José Ricardo Andrade, Tino Lang, Ayhan Tajalli, and Uwe Morgner
Published in: 2017 European Conference on Lasers and Electro-Optics and European Quantum Electronics Conference, Issue 2017, 2017

Polyp malignancy classification with CNN features based on Blue Laser and Linked Color Imaging

Author(s): Roger Fonolla Navarro, Fons Van Der Sommen, Peter H N De With, Ramon M Schreuder, Erik J Schoon
Published in: Proceedings of NCCV2018, 2018

Hand-Eye Camera Calibration with an Optical Tracking System

Author(s): Marco Lai, Caifeng Shan, Peter H.N. de With
Published in: Proceedings of the 12th International Conference on Distributed Smart Cameras - ICDSC '18, 2018, Page(s) 1-6
DOI: 10.1145/3243394.3243700

Image fusion on the endoscopic view for endo-nasal skull-base surgery

Author(s): Marco Lai, Caifeng Shan, Drazenko Babic, Robert Homan, Adrian Elmi Terander, Erik Edstrom, Oscar Persson, Gustav Burstrom, Peter H. N. de With
Published in: Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 2019, Page(s) 48
DOI: 10.1117/12.2512734

Tuning of an integrated tunable laser for swept source optical coherence tomography Tuning of an Integrated Tunable Laser for Swept Source Optical Coherence Tomography

Author(s): Rastko Pajković, Kevin Williams, Erwin Bente
Published in: Tuning of an integrated tunable laser for swept source optical coherence tomography, 2017, Page(s) 164-167

Multi-Modal Classification of Polyp Malignancy using CNN Features with Balanced Class Augmentation

Author(s): Roger Fonolla, Fons van der Sommen, Ramon M. Schreuder, Erik J. Schoon, Peter H.N. de With
Published in: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), 2019, Page(s) 74-78
DOI: 10.1109/isbi.2019.8759320

Dynamic properties of wavelength switching in a widely tunable semiconductor laser for optical coherence tomography

Author(s): Rastko Pajkovic, Daniel Garbi, Kevin Williams, Erwin Bente
Published in: Semiconductor Lasers and Laser Dynamics IX, Issue 2020, 2020, Page(s) 19
DOI: 10.1117/12.2555620

Automated classification of brain tissue: comparison between hyperspectral imaging and diffuse reflectance spectroscopy

Author(s): Marco Lai, Simon Skyrman, Caifeng Shan, Elvira Paulussen, Francesca Manni, Akash Swamy, Drazenko Babic, Erik Edström, Oscar Persson, Gustav Burström, Adrian Elmi Terander, Benno H. W. Hendriks, Peter H. N. de With
Published in: Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling, Issue 2020, 2020, Page(s) 62
DOI: 10.1117/12.2548754

IMPROVING OPTICAL DIAGNOSIS OF COLORECTAL POLYPS USING COMPUTER-AIDED DIAGNOSIS (CADX)

Author(s): QEW van der Zander, RM Schreuder, R Fonolla, T Scheeve, F van der Sommen, P Aepli, B Hayee, A Pischel, M Stefanovic, S Subramaniam, P Bhandari, PHN de With, AAM Masclee, EJ Schoon
Published in: ESGE Days, Issue 52(S 01), 2020
DOI: 10.1055/s-0040-1704736

Hyperspectral imaging for colon cancer classification in surgical specimens: towards optical biopsy during image-guided surgery

Author(s): Francesca Manni, Roger Fonolla, Fons van der Sommen, Svetlana Zinger, Caifeng Shan, Esther Kho, Susan Brouwer de Koning, Theo Ruers, Peter H.N. de With
Published in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Page(s) 1169-1173
DOI: 10.1109/embc44109.2020.9176543