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Innovative training in methods for future data

Deliverables

Outreach activities first year of projects

Report on outreach activities in the first year of the projects

Recruitment strategy in place

Strategy for recruitment of excellent ESRs

Publications

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation

Author(s): Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-00453-3

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

Author(s): Ivan Gudelj, Perttu P. Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1864/6, 2018, Page(s) 2034-2039, ISSN 0925-4439
DOI: 10.1016/j.bbadis.2018.03.018

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Author(s): Shaza B Zaghlool, Dennis O Mook-Kanamori, Sara Kader, Nisha Stephan, Anna Halama, Rudolf Engelke, Hina Sarwath, Eman K Al-Dous, Yasmin A Mohamoud, Werner Roemisch-Margl, Jerzy Adamski, Gabi Kastenmüller, Nele Friedrich, Alessia Visconti, Pei-Chien Tsai, Tim Spector, Jordana T Bell, Mario Falchi, Annika Wahl, Melanie Waldenberger, Annette Peters, Christian Gieger, Marija Pezer, Gordan Lauc, Johann
Published in: Human Molecular Genetics, Issue 27/6, 2018, Page(s) 1106-1121, ISSN 0964-6906
DOI: 10.1093/hmg/ddy006

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Author(s): Alyce C. Russell, Agnieszka Kepka, Irena Trbojević-Akmačić, Ivo Ugrina, Manshu Song, Jennie Hui, Michael Hunter, Simon M. Laws, Gordan Lauc, Wei Wang
Published in: Immunobiology, Issue 224/1, 2019, Page(s) 110-115, ISSN 0171-2985
DOI: 10.1016/j.imbio.2018.10.002

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Author(s): Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A. Kennedy, Jerko Štambuk, David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Dermot P.B. McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc, Harry Campbell, Vlatka Zoldoš, Iain K. Permberton, Daniel Kolarich, D
Published in: Gastroenterology, Issue 154/5, 2018, Page(s) 1320-1333.e10, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.01.002

Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes

Author(s): Najda Rudman, Olga Gornik, Gordan Lauc
Published in: FEBS Letters, 2019, ISSN 0014-5793
DOI: 10.1002/1873-3468.13495

Expanding the Reaction Space of Linkage-Specific Sialic Acid Derivatization

Author(s): Tamas Pongracz, Manfred Wuhrer, Noortje de Haan
Published in: Molecules, Issue 24/19, 2019, Page(s) 3617, ISSN 1420-3049
DOI: 10.3390/molecules24193617

The Role of the Central Limit Theorem in the Heterogeneous Ensemble of Brownian Particles Approach

Author(s): Silvia Vitali, Iva Budimir, Claudio Runfola, Gastone Castellani
Published in: Mathematics, Issue 7/12, 2019, Page(s) 1145, ISSN 2227-7390
DOI: 10.3390/MATH7121145

Evaluation of pre-processing on the meta-analysis of DNA methylation data from the Illumina HumanMethylation450 BeadChip platform

Author(s): Claudia Sala, Pietro Di Lena, Danielle Fernandes Durso, Andrea Prodi, Gastone Castellani, Christine Nardini
Published in: PLOS ONE, Issue 15/3, 2020, Page(s) e0229763, ISSN 1932-6203
DOI: 10.1371/journal.pone.0229763

Why Not Use the Immunoglobulin G N -Glycans as Predictor Variables in Disease Biomarker–Phenotype Association Studies? A Multivariate Analysis

Author(s): Alyce C. Russell, Agnieszka Kepka, Irena Trbojević-Akmačić, Ivo Ugrina, Manshu Song, Jennie Hui, Michael Hunter, Simon M. Laws, Gordan Lauc, Wei Wang
Published in: OMICS: A Journal of Integrative Biology, Issue 23/12, 2019, Page(s) 668-670, ISSN 1557-8100
DOI: 10.1089/omi.2019.0155

Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population

Author(s): Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang
Published in: OMICS: A Journal of Integrative Biology, Issue 23/12, 2019, Page(s) 640-648, ISSN 1557-8100
DOI: 10.1089/omi.2019.0052

Choosing proper normalization is essential for discovery of sparse glycan biomarkers

Author(s): Hae-Won Uh, Lucija Klarić, Ivo Ugrina, Gordan Lauc, Age K. Smilde, Jeanine J. Houwing-Duistermaat
Published in: Molecular Omics, Issue 16/3, 2020, Page(s) 231-242, ISSN 2515-4184
DOI: 10.1039/c9mo00174c