Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia

Deliverables

Internet blog together with patients’ organisation

Internet blog and Twitter feeds together with patients’ organisation

EU-GliaPhD project website

Press conference on the EU-GliaPhD network

Press conference on network

Report on successful awarding of PhD degrees to all ESRs
First publications of EU-GliaPhD fellows

First publications of ESRs

Publications

Biphasic Impact of Prenatal Inflammation and Macrophage Depletion on the Wiring of Neocortical Inhibitory Circuits

Author(s): Morgane Sonia Thion, Coralie-Anne Mosser, Isabelle Férézou, Pauline Grisel, Sofia Baptista, Donovan Low, Florent Ginhoux, Sonia Garel, Etienne Audinat
Published in: Cell Reports, Issue 28/5, 2019, Page(s) 1119-1126.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.06.086

From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research

Author(s): Davide Gobbo, Anja Scheller, Frank Kirchhoff
Published in: Frontiers in Neurology, Issue 12, 2021, Page(s) 661408, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.661408

Editorial: Glial Dysfunction in Epileptogenesis

Author(s): Kjell Heuser, Marco de Curtis, Christian Steinhäuser
Published in: Frontiers in Neurology, Issue 12, 2021, Page(s) 716308, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.716308

Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes

Author(s): Anna Welle, Carmen V. Kasakow, Annemarie M. Jungmann, Davide Gobbo, Laura Stopper, Karl Nordström, Abdulrahman Salhab, Gilles Gasparoni, Anja Scheller, Frank Kirchhoff, Jörn Walter
Published in: Glia, Issue 69/9, 2021, Page(s) 2160-2177, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24016

The many ways astroglial connexins regulate neurotransmission and behavior

Author(s): David Mazaud, Anna Capano, Nathalie Rouach
Published in: Glia, Issue 69/11, 2021, Page(s) 2527-2545, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24040

The Paradox of Astroglial Ca2 + Signals at the Interface of Excitation and Inhibition

Author(s): Laura C. Caudal, Davide Gobbo, Anja Scheller, Frank Kirchhoff
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, Page(s) 609947, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.609947

Elucidating regulators of astrocytic Ca 2+ signaling via multi‐threshold event detection ( MTED )

Author(s): Franziska E. Müller, Volodymyr Cherkas, Gebhard Stopper, Laura C. Caudal, Laura Stopper, Frank Kirchhoff, Christian Henneberger, Evgeni G. Ponimaskin, Andre Zeug
Published in: Glia, Issue 2021, 2021, Page(s) 1-14, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24070

Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis

Author(s): Till S. Zimmer, Diede W. M. Broekaart, Victoria-Elisabeth Gruber, Erwin A. van Vliet, Angelika Mühlebner, Eleonora Aronica
Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 1028, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.01028

Chronic activation of anti‐oxidant pathways and iron accumulation in epileptogenic malformations

Author(s): T. S. Zimmer, G. Ciriminna, A. Arena, J. J. Anink, A. Korotkov, F. E. Jansen, W. Hecke, W. G. Spliet, P. C. Rijen, J. C. Baayen, S. Idema, N. R. Rensing, M. Wong, J. D. Mills, E. A. Vliet, E. Aronica
Published in: Neuropathology and Applied Neurobiology, Issue 46/6, 2020, Page(s) 546-563, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12596

Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances

Author(s): Annamaria Lia, Vanessa Jorge Henriques, Micaela Zonta, Angela Chiavegato, Giorgio Carmignoto, Marta Gómez-Gonzalo, Gabriele Losi
Published in: Frontiers in Cellular Neuroscience, Issue 15, 2021, Page(s) 673433, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2021.673433

Nye veier å gå for bedre epilepsibehandling

Author(s): Kjell Heuser, Rune Enger, Toni Berger, Erik Taubøll
Published in: Tidsskrift for Den norske legeforening, Issue 09-2021, 2021, Page(s) 1-2, ISSN 0029-2001
Publisher: Norwegian Medical Assocation
DOI: 10.4045/tidsskr.21.0469

Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

Author(s): Yasmine Iacone, Tatiana P. Morais, François David, Francis Delicata, Joanna Sandle, Timea Raffai, Harri Rheinallt Parri, Johan Juhl Weisser, Christoffer Bundgaard, Ib Vestergaard Klewe, Gábor Tamás, Morten Skøtt Thomsen, Vincenzo Crunelli, Magor L. Lőrincz
Published in: Epilepsia, Issue 62/7, 2021, Page(s) 1729-1743, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.16926

Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

Author(s): Till S. Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E. Jansen, Fried J. T. Zwartkruis, Nicholas R. Rensing, Michael Wong, Angelika Mühlebner, Erwin A. Vliet, Eleonora Aronica, James D. Mills
Published in: Brain Pathology, Issue 31/5, 2021, Page(s) e12949, ISSN 1015-6305
Publisher: International Society of Neuropathology
DOI: 10.1111/bpa.12949

Technical characterization of an 8 or 16 channel recording system to acquire electrocorticograms of mice

Author(s): Robert Englert, Fabienne Rupp, Frank Kirchhoff, Klaus Peter Koch, Michael Schweigmann
Published in: Current Directions in Biomedical Engineering, Issue 3/2, 2017, Page(s) 595-598, ISSN 2364-5504
Publisher: De Gruyter
DOI: 10.1515/cdbme-2017-0124

Initiation of Experimental Temporal Lobe Epilepsy by Early Astrocyte Uncoupling Is Independent of TGFβR1/ALK5 Signaling

Author(s): Lukas Henning, Christian Steinhäuser, Peter Bedner
Published in: Frontiers in Neurology, Issue 12, 2021, Page(s) 660591, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.660591

Versatile Surface Electrodes for Combined Electrophysiology and Two-Photon Imaging of the Mouse Central Nervous System

Author(s): Michael Schweigmann, Laura C. Caudal, Gebhard Stopper, Anja Scheller, Klaus P. Koch, Frank Kirchhoff
Published in: Frontiers in Cellular Neuroscience, Issue 15, 2021, Page(s) 720675, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2021.720675

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Author(s): Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, Daisuke Hagiwara, Arthur Lefevre, Lara Barteczko, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Da Silva Gouveia, Diego Benusiglio, Marina Eliava, Andrei Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudi
Published in: Nature Neuroscience, Issue 24/4, 2021, Page(s) 529-541, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-021-00800-0

Astrocytic Ca2+ Signaling in Epilepsy

Author(s): Kjell Heuser, Rune Enger
Published in: Frontiers in Cellular Neuroscience, Issue 15, 2021, Page(s) 695380, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2021.695380

Balloon cells promote immune system activation in focal cortical dysplasia type 2b

Author(s): Till S. Zimmer, Diede W. M. Broekaart, Mark Luinenburg, Caroline Mijnsbergen, Jasper J. Anink, Nam Suk Sim, Iliana Michailidou, Floor E. Jansen, Peter C. Rijen, Jeong Ho Lee, Liesbeth François, Jonathan Eyll, Stefanie Dedeurwaerdere, Erwin A. Vliet, Angelika Mühlebner, James D. Mills, Eleonora Aronica
Published in: Neuropathology and Applied Neurobiology, Issue 00, 2021, Page(s) 1-14, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12736

Differential Glial Activation in Early Epileptogenesis—Insights From Cell-Specific Analysis of DNA Methylation and Gene Expression in the Contralateral Hippocampus

Author(s): Toni C. Berger, Magnus D. Vigeland, Hanne S. Hjorthaug, Cecilie G. Nome, Erik Taubøll, Kaja K. Selmer, Kjell Heuser
Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 573575, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.573575

Seizure-Induced Acute Glial Activation in the in vitro Isolated Guinea Pig Brain

Author(s): Diogo Vila Verde, Marco de Curtis, Laura Librizzi
Published in: Frontiers in Neurology, Issue 12, 2021, Page(s) 607603, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.607603

Astroglial Cx30 sustains neuronal population bursts independently of gap‐junction mediated biochemical coupling

Author(s): Ulrike Pannasch, Elena Dossi, Pascal Ezan, Nathalie Rouach
Published in: Glia, Issue 67/6, 2019, Page(s) 1104-1112, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23591

Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis

Author(s): Toni C. Berger, Magnus D. Vigeland, Hanne S. Hjorthaug, Lars Etholm, Cecilie G. Nome, Erik Taubøll, Kjell Heuser, Kaja K. Selmer
Published in: PLOS ONE, Issue 14/12, 2019, Page(s) e0226575, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0226575

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning

Author(s): Noémie Mazaré, Marc Oudart, Julien Moulard, Giselle Cheung, Romain Tortuyaux, Philippe Mailly, David Mazaud, Alexis-Pierre Bemelmans, Anne-Cécile Boulay, Corinne Blugeon, Laurent Jourdren, Stéphane Le Crom, Nathalie Rouach, Martine Cohen-Salmon
Published in: Cell Reports, Issue 32/8, 2020, Page(s) 108076, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108076

Do Astrocytes Play a Role in Intellectual Disabilities?

Author(s): Noémie Cresto, Laure-Elise Pillet, Pierre Billuart, Nathalie Rouach
Published in: Trends in Neurosciences, Issue 42/8, 2019, Page(s) 518-527, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2019.05.011

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes

Author(s): Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta, Linda Maria Requie, Iacopo Marcon, Arianna Pugliese, Cécile Viollet, Bernhard Bettler, Tommaso Fellin, Fiorenzo Conti, Giorgio Carmignoto
Published in: Nature Communications, Issue 9/1, 2018, Page(s) 82, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02642-6

Versatile control of synaptic circuits by astrocytes: where, when and how?

Author(s): Glenn Dallérac, Jonathan Zapata, Nathalie Rouach
Published in: Nature Reviews Neuroscience, Issue 19/12, 2018, Page(s) 729-743, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-018-0080-6

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Author(s): Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Detlev Boison, Martin J. Brodie, Amy R. Brooks-Kayal, Jerome Engel, Patrick A. Forcelli, Lawrence J. Hirsch, Rafal M. Kaminski, Henrik Klitgaard, Katja Kobow, Daniel H. Lowenstein, Phillip L. Pearl, Asla Pitkänen, Noora Puhakka, Michael A. Rogawski, Dieter Schmidt, Matti Sillanpää, Robert S. Sloviter, Christ
Published in: Epilepsia, Issue 59/1, 2018, Page(s) 37-66, ISSN 0013-9580
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/epi.13965

Disentangling astroglial physiology with a realistic cell model in silico

Author(s): Leonid P. Savtchenko, Lucie Bard, Thomas P. Jensen, James P. Reynolds, Igor Kraev, Nikolay Medvedev, Michael G. Stewart, Christian Henneberger, Dmitri A. Rusakov
Published in: Nature Communications, Issue 9/1, 2018, Page(s) 3554, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05896-w

Astroglial Glutamate Signaling and Uptake in the Hippocampus

Author(s): Christine R. Rose, Lisa Felix, Andre Zeug, Dirk Dietrich, Andreas Reiner, Christian Henneberger
Published in: Frontiers in Molecular Neuroscience, Issue 10, 2018, Page(s) 451, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2017.00451

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

Author(s): Andrea Arena, Till S. Zimmer, Jackelien van Scheppingen, Anatoly Korotkov, Jasper J. Anink, Angelika Mühlebner, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Annamaria Vezzani, Johannes C. Baayen, Sander Idema, Anand M. Iyer, Marzia Perluigi, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Published in: Brain Pathology, 2018, ISSN 1015-6305
Publisher: International Society of Neuropathology
DOI: 10.1111/bpa.12661

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes

Author(s): Jackelien van Scheppingen, James D. Mills, Till S. Zimmer, Diede W.M. Broekaart, Valentina Iori, Anika Bongaarts, Jasper J. Anink, Anand M. Iyer, Anatoly Korotkov, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Johannes C. Baayen, Annamaria Vezzani, Erwin A. van Vliet, Eleonora Aronica
Published in: Glia, Issue 66/5, 2018, Page(s) 1082-1097, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23302

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

Author(s): James D. Mills, Anand M. Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J. Anink, Bart Janssen, Till S. Zimmer, Wim G. Spliet, Peter C. van Rijen, Floor E. Jansen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J. Kwiatkowski, R. Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von
Published in: Scientific Reports, Issue 7/1, 2017, Page(s) 8089, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-06145-8

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy

Author(s): A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica
Published in: Scientific Reports, Issue 7/1, 2017, Page(s) 11592, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-11510-8

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

Author(s): Cian McCafferty, François David, Marcello Venzi, Magor L. Lőrincz, Francis Delicata, Zoe Atherton, Gregorio Recchia, Gergely Orban, Régis C. Lambert, Giuseppe Di Giovanni, Nathalie Leresche, Vincenzo Crunelli
Published in: Nature Neuroscience, Issue 21/5, 2018, Page(s) 744-756, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0130-4

Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia

Author(s): Hannah M. Jahn, Carmen V. Kasakow, Andreas Helfer, Julian Michely, Alexei Verkhratsky, Hans H. Maurer, Anja Scheller, Frank Kirchhoff
Published in: Scientific Reports, Issue 8/1, 2018, Page(s) 5913, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24085-9

MicroRNA‐34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis

Author(s): Anatoly Korotkov, Nam Suk Sim, Mark J. Luinenburg, Jasper J. Anink, Jackelien Scheppingen, Till S. Zimmer, Anika Bongaarts, Diede W. M. Broekaart, Caroline Mijnsbergen, Floor E. Jansen, Wim Van Hecke, Wim G. M. Spliet, Peter C. Rijen, Martha Feucht, Johannes A. Hainfellner, Pavel Kršek, Josef Zamecnik, Peter B. Crino, Katarzyna Kotulska, Lieven Lagae, Anna C. Jansen, David J. Kwiatkowski, Sergius
Published in: Neuropathology and Applied Neurobiology, Issue 00, 2021, Page(s) 1-16, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12717

The intellectual disability protein Oligophrenin‐1 controls astrocyte morphology and migration

Author(s): Laure‐Elise Pillet, Noémie Cresto, Yoann Saillour, Grégory Ghézali, Alexis‐Pierre Bemelmans, Jean Livet, Thierry Bienvenu, Nathalie Rouach, Pierre Billuart
Published in: Glia, Issue 68/9, 2020, Page(s) 1729-1742, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23801

Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy

Author(s): Julia Müller, Aline Timmermann, Lukas Henning, Hendrik Müller, Christian Steinhäuser, Peter Bedner
Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 614923, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.614923

Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms

Author(s): Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhäuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Published in: Cells, Issue 9/2, 2020, Page(s) 382, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9020382

Neuronal Activity Drives Astroglial Connexin 30 in Perisynaptic Processes and Shapes Its Functions

Author(s): Grégory Ghézali, Flora Vasile, Nathan Curry, Marcus Fantham, Giselle Cheung, Pascal Ezan, Martine Cohen-Salmon, Clemens Kaminski, Nathalie Rouach
Published in: Cerebral Cortex, Issue 30/2, 2019, Page(s) 753-766, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz123

Structural and functional connections between the median and the ventrolateral preoptic nucleus

Author(s): Augustin Walter, Lorijn van der Spek, Eléonore Hardy, Alexis Pierre Bemelmans, Nathalie Rouach, Armelle Rancillac
Published in: Brain Structure and Function, Issue 224/9, 2019, Page(s) 3045-3057, ISSN 1863-2653
Publisher: Springer Verlag
DOI: 10.1007/s00429-019-01935-4

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