Natural Toxins and Drinking Water Quality - From Source to Tap

Informations projet

NaToxAq

N° de convention de subvention: 722493

DOI 10.3030/722493

Projet clôturé

Date de signature de la CE 16 Août 2016

Date de début 1 Janvier 2017

Date de fin 31 Decembre 2020

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 3 976 833,96

Contribution de l’UE € 3 976 833,96

Coordonné par

KOBENHAVNS UNIVERSITET
Denmark

Livrables

Websites, patent fillings, videos etc. (14)

Info portal on website created by ESRs 2

Info portal on website created by ESRs

Upload of data to databases and achieves 5

Upload of data to databases and achieves

Info portal on website created by ESRs 5

Info portal on website created by ESRs

Upload of data to databases and achieves 4

Upload of data to databases and achieves

Info portal on website created by ESRs 6

Info portal on website created by ESRs

Upload of data to databases and achieves 3

Upload of data to databases and achieves

Info portal on website created by ESRs 4

Info portal on website created by ESRs

Database on natural toxins in Europe
Upload of data to databases and achieves 1

Upload of data to databases and achieves

Info portal on website created by ESRs 3

Info portal on website created by ESRs

Website established including newsletter function
Upload of data to databases and achieves 6

Upload of data to databases and achieves

Upload of data to databases and achieves 2

Upload of data to databases and achieves

Info portal on website created by ESRs 1

Info portal on website created by ESRs

Documents, reports (36)

LCn and HR-MS screening methods for natural toxins
Proposed measures to prevent contamination
Compilation of state-of-the art water treatment methods for toxins

Compilation of stateofthe art water treatment methods for toxins

DAISY transport model adapted to natural toxins in climate scenario
High-throughput methods for phys-chem property determinations
Minutes from plenary meetings 1

Minutes from plenary meetings

In silico tools applicable to natural toxins
Non-target screening of natural toxins along climate gradients

Nontarget screening of natural toxins along climate gradients

Minutes from plenary meetings 3

Minutes from plenary meetings

Proceedings from final conference
Toxicity fingerprints of invasive species at climate gradients
Protocol for office operation
Minutes from plenary meetings 2

Minutes from plenary meetings

Conflict management plan
Toxicological endpoints and health risk assessment
Report from stakeholder meetings 1

Report from stakeholder meetings

Publication of ISI papers and conference proceedings
LC-MS/MS and immunosensor methods for targeted screening
Course Programme
Report from stakeholder meetings 2

Report from stakeholder meetings

Priority setting for natural toxins in the water cycle
Mass balances in natural toxin field investigations
Toxicity of new cyanobacterial toxins to gut and immune cells
Quality assurance of in silico models for parameter estimations
Publication or reviews, books and book chapters
Mentoring programme
Course plan – all courses
Final report to EU
Natural toxins depending on land cover and climate in Europe
Compilation of rate constants for dissipation processes
Dissemination routines
Partitioning and stability constants
Temporal and spatial variation in natural toxin emission
Candidate toxins for river basin specific pollutants
Non-thermal plasma and other methods for natural toxin removal
Leaching of natural toxins to drinking water reservoir

Other (9)

Communication via social media and “ambassador” activities 6

Communication via social media and “ambassador” activities

Communication via social media and “ambassador” activities 5

Communication via social media and “ambassador” activities

Advertisement of ESR positions
Communication via social media and “ambassador” activities 3

Communication via social media and ambassador activities

Meetings and seminars with stakeholders; public events 1

Meetings and seminars with stakeholders public events

Communication via social media and “ambassador” activities 4

Communication via social media and ambassador activities

Meetings and seminars with stakeholders; public events 2

Meetings and seminars with stakeholders; public events

Communication via social media and “ambassador” activities 2

Communication via social media and ambassador activities

Communication via social media and “ambassador” activities 1

Communication via social media and “ambassador” activities

Demonstrators, pilots, prototypes (1)

Effect-directed identification tools for water soluble toxins

Publications

Peer reviewed articles (38)

Occurrence of pyrrolizidine alkaloids in ragwort plants, soils and surface waters at the field scale in grassland

Auteurs: Jawameer R. Hama, Bjarne W. Strobel
Publié dans: Science of The Total Environment, Numéro 755, 2021, Page(s) 142822, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2020.142822

Suspect screening of natural toxins in surface and drinking water by high performance liquid chromatography and high-resolution mass spectrometry

Auteurs: Massimo Picardo, Josep Sanchís, Oscar Núñez, Marinella Farré
Publié dans: Chemosphere, Numéro 261, 2020, Page(s) 127888, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.127888

Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Auteurs: Daria Filatova, Oscar Núñez, Marinella Farré
Publié dans: Toxins, Numéro 12/4, 2020, Page(s) 247, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12040247

A Novel Method for Determination of the Natural Toxin Ptaquiloside in Ground and Drinking Water

Auteurs: Natasa Skrbic, Ann-Katrin Pedersen, Sarah C. B. Christensen, Hans Christian Bruun Hansen, Lars Holm Rasmussen
Publié dans: Water, Numéro 12/10, 2020, Page(s) 2852, ISSN 2073-4441
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/w12102852

Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

Auteurs: Barbara Kubickova, Carmel Ramwell, Klara Hilscherova, Miriam Naomi Jacobs
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, Page(s) 1-38, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00428-0

Cylindrospermopsin is effectively degraded in water by pulsed corona-like and dielectric barrier discharges

Auteurs: Marcel Schneider, Raphael Rataj, Juergen F. Kolb, Luděk Bláha
Publié dans: Environmental Pollution, Numéro 266, 2020, Page(s) 115423, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.115423

Target screening of plant secondary metabolites in river waters by liquid chromatography coupled to high-resolution mass spectrometry (LC–HRMS)

Auteurs: Mulatu Yohannes Nanusha, Martin Krauss, Carina D. Schönsee, Barbara F. Günthardt, Thomas D. Bucheli, Werner Brack
Publié dans: Environmental Sciences Europe, Numéro 32/1, 2020, Page(s) 1-11, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00399-2

Enhancing the power of liquid chromatography–Mass spectrometry for chemical fingerprinting of phytotoxins in the environment

Auteurs: Xiaomeng Liang, Jan H. Christensen, Nikoline Juul Nielsen
Publié dans: Journal of Chromatography A, Numéro 1642, 2021, Page(s) 462027, ISSN 0021-9673
Éditeur: Elsevier BV
DOI: 10.1016/j.chroma.2021.462027

Occurrence of plant secondary metabolite fingerprints in river waters from Eastern Jutland, Denmark

Auteurs: Mulatu Yohannes Nanusha, Martin Krauss, Bettina Gro Sørensen, Tobias Schulze, Bjarne W. Strobel, Werner Brack
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00464-4

Natural alkaloids from narrow-leaf and yellow lupins transfer to soil and soil solution in agricultural fields

Auteurs: Jawameer R. Hama, Bjarne W. Strobel
Publié dans: Environmental Sciences Europe, Numéro 32/1, 2020, Page(s) 12 pages + 6 pages supplementary, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00405-7

Disentangling Mechanisms in Natural Toxin Sorption to Soil Organic Carbon

Auteurs: Carina D. Schönsee, Felix E. Wettstein, Thomas D. Bucheli
Publié dans: Environmental Science & Technology, 2021, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.0c06634

Phototransformation kinetics of cyanobacterial toxins and secondary metabolites in surface waters

Auteurs: Regiane Natumi, Sandro Marcotullio, Elisabeth M.-L. Janssen
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00465-3

Does the natural carcinogen ptaquiloside degrade readily in groundwater?

Auteurs: Jane S. Wu, Frederik Clauson-Kaas, Dan Nybro Lindqvist, Lars Holm Rasmussen, Bjarne W. Strobel, Hans Christian Bruun Hansen
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00468-0

Occurrence of carcinogenic illudane glycosides in drinking water wells

Auteurs: Natasa Skrbic, Vaidotas Kisielius, Ann-Katrin Pedersen, Sarah C. B. Christensen, Mathilde J. Hedegaard, Hans Christian Bruun Hansen, Lars Holm Rasmussen
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, Page(s) 1-11, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00486-y

Bracken growth, toxin production and transfer from plant to soil: a 2-year monitoring study

Auteurs: Daniel B. García-Jorgensen, Efstathios Diamantopoulos, Vaidotas Kisielius, Mette Rosenfjeld, Lars H. Rasmussen, Bjarne W. Strobel, Hans Chr. B. Hansen
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00484-0

Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity

Auteurs: Massimo Picardo, Oscar Núñez, Marinella Farré
Publié dans: Toxins, Numéro 12/12, 2020, Page(s) 752, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12120752

Analysis, levels and seasonal variation of cyanotoxins in freshwater ecosystems

Auteurs: Daria Filatova, Massimo Picardo, Oscar Núñez, Marinella Farré
Publié dans: Trends in Environmental Analytical Chemistry, Numéro 26, 2020, Page(s) e00091, ISSN 2214-1588
Éditeur: Elsevier BV
DOI: 10.1016/j.teac.2020.e00091

Personal Care Products Are Only One of Many Exposure Routes of Natural Toxic Substances to Humans and the Environment

Auteurs: Thomas Bucheli, Bjarne Strobel, Hans Hansen
Publié dans: Cosmetics, Numéro 5/1, 2018, Page(s) 10, ISSN 2079-9284
Éditeur: Cosmetics, MDPI AG, Basel, Switzerland
DOI: 10.3390/cosmetics5010010

Recent advances in the detection of natural toxins in freshwater environments

Auteurs: Massimo Picardo, Daria Filatova, Oscar Nuñez, Marinella Farré
Publié dans: TrAC Trends in Analytical Chemistry, Numéro 112, 2019, Page(s) 75-86, ISSN 0165-9936
Éditeur: Elsevier BV
DOI: 10.1016/j.trac.2018.12.017

Effects of cylindrospermopsin on cultured immortalized human airway epithelial cells

Auteurs: Barbara Kubickova, Petra Laboha, Jan-Peter Hildebrandt, Klara Hilscherová, Pavel Babica
Publié dans: Chemosphere, Numéro 220, 2019, Page(s) 620-628, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2018.12.157

Cyanobacterial peptides beyond microcystins – A review on co-occurrence, toxicity, and challenges for risk assessment

Auteurs: Elisabeth M.-L. Janssen
Publié dans: Water Research, Numéro 151, 2019, Page(s) 488-499, ISSN 0043-1354
Éditeur: Elsevier BV
DOI: 10.1016/j.watres.2018.12.048

Effects of cyanobacterial toxins on the human gastrointestinal tract and the mucosal innate immune system

Auteurs: Barbara Kubickova, Pavel Babica, Klára Hilscherová, Lenka Šindlerová
Publié dans: Environmental Sciences Europe, Numéro 31/1, 2019, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-019-0212-2

Fate of ptaquiloside—A bracken fern toxin—In cattle

Auteurs: Paulo César dos Reis Aranha, Lars Holm Rasmussen, Godelind Alma Wolf-Jäckel, Henrik Michael Elvang Jensen, Hans Christian Bruun Hansen, Christian Friis
Publié dans: PLOS ONE, Numéro 14/6, 2019, Page(s) e0218628, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0218628

Pyrrolizidine alkaloids quantified in soil and water using UPLC-MS/MS

Auteurs: Jawameer R. Hama, Bjarne W. Strobel
Publié dans: RSC Advances, Numéro 9/52, 2019, Page(s) 30350-30357, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9ra05301h

Experimental Determination of Octanol–Water Partition Coefficients of Selected Natural Toxins

Auteurs: Carina D. Schönsee, Thomas D. Bucheli
Publié dans: Journal of Chemical & Engineering Data, Numéro 65/4, 2020, Page(s) 1946-1953, ISSN 0021-9568
Éditeur: American Chemical Society
DOI: 10.1021/acs.jced.9b01129

Hemorrhagic diathesis in cattle due to consumption of Adiantopsis chlorophylla (Swartz) Fée (Pteridaceae)

Auteurs: Luiz Gustavo Schneider de Oliveira, Fabiana Marques Boabaid, Vaidotas Kisielius, Lars Holm Rasmussen, Florencia Buroni, Martín Lucas, Carlos Omar Schild, Fabiana López, Mizael Machado, Franklin Riet-Correa
Publié dans: Toxicon: X, Numéro 5, 2020, Page(s) 100024, ISSN 2590-1710
Éditeur: Elsevier
DOI: 10.1016/j.toxcx.2020.100024

"""Is there anybody else out there?"" – First Insights from a Suspect Screening for Phytotoxins in Surface Water"

Auteurs: Barbara F. Günthardt, Carina D. Schönsee, Juliane Hollender, Konrad Hungerbühler, Martin Scheringer, Thomas D. Bucheli
Publié dans: CHIMIA International Journal for Chemistry, Numéro 74/3, 2020, Page(s) 129-135, ISSN 0009-4293
Éditeur: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2020.129

Fast LC-MS quantification of ptesculentoside, caudatoside, ptaquiloside and corresponding pterosins in bracken ferns

Auteurs: Vaidotas Kisielius, Dan Nybro Lindqvist, Mikkel Boas Thygesen, Michael Rodamer, Hans Christian Bruun Hansen, Lars Holm Rasmussen
Publié dans: Journal of Chromatography B, Numéro 1138, 2020, Page(s) 121966, ISSN 1570-0232
Éditeur: Elsevier BV
DOI: 10.1016/j.jchromb.2019.121966

Selective pressurized liquid extraction of plant secondary metabolites: Convallaria majalis L. as a case

Auteurs: Xiaomeng Liang, Nikoline Juul Nielsen, Jan H. Christensen
Publié dans: Analytica Chimica Acta: X, Numéro 4, 2020, Page(s) 100040, ISSN 2590-1346
Éditeur: Analytica Chimica Acta: X
DOI: 10.1016/j.acax.2020.100040

Cyanopeptide Co-Production Dynamics beyond Mirocystins and Effects of Growth Stages and Nutrient Availability

Auteurs: Regiane Natumi, Elisabeth M.-L. Janssen
Publié dans: Environmental Science & Technology, Numéro 54/10, 2020, Page(s) 6063-6072, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.9b07334

Inhibition of Extracellular Enzymes Exposed to Cyanopeptides

Auteurs: Christine M. Egli, Regiane S. Natumi, Martin R. Jones, Elisabeth M.-L. Janssen
Publié dans: CHIMIA International Journal for Chemistry, Numéro 74/3, 2020, Page(s) 122-128, ISSN 0009-4293
Éditeur: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2020.122

Microcystin-LR Does Not Alter Cell Survival and Intracellular Signaling in Human Bronchial Epithelial Cells

Auteurs: Ondřej Brózman, Barbara Kubickova, Pavel Babica, Petra Laboha
Publié dans: Toxins, Numéro 12/3, 2020, Page(s) 165, ISSN 2072-6651
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12030165

Advanced oxidation processes for the removal of cyanobacterial toxins from drinking water

Auteurs: Marcel Schneider, Luděk Bláha
Publié dans: Environmental Sciences Europe, Numéro 32/1, 2020, Page(s) The article has 24 pages in total (incl. references, acknowledgments, disclaimer, etc.), ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00371-0

The invasive butterbur contaminates stream and seepage water in groundwater wells with toxic pyrrolizidine alkaloids

Auteurs: Vaidotas Kisielius, Jawameer R. Hama, Natasa Skrbic, Hans Christian Bruun Hansen, Bjarne W. Strobel, Lars Holm Rasmussen
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-76586-1

Toxicity and risk of plant-produced alkaloids to Daphnia magna

Auteurs: Megan R. Griffiths, Bjarne W. Strobel, Jawameer R. Hama, Nina Cedergreen
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, Page(s) 12, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00452-0

Phytotoxin sorption to clay minerals

Auteurs: Carina D. Schönsee, Felix E. Wettstein, Thomas D. Bucheli
Publié dans: Environmental Sciences Europe, Numéro 33/1, 2021, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-021-00469-z

A novel model concept for modelling the leaching of natural toxins: results for the case of ptaquiloside

Auteurs: D. B. García-Jorgensen, H. C. B. Hansen, P. Abrahamsen, E. Diamantopoulos
Publié dans: Environmental Science: Processes & Impacts, Numéro 22/8, 2020, Page(s) 1768-1779, ISSN 2050-7887
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0em00182a

Non-target screening for detecting the occurrence of plant metabolites in river waters

Auteurs: Mulatu Yohannes Nanusha, Martin Krauss, Werner Brack
Publié dans: Environmental Sciences Europe, Numéro 32/1, 2020, Page(s) 1-14, ISSN 2190-4707
Éditeur: Springer Verlag
DOI: 10.1186/s12302-020-00415-5

Other (1)

Comprehensive database of secondary metabolites from cyanobacteria

Auteurs: Pearse McCarron; Hanna Mazur-Marzec; Jouni Jokela; Luciana Tartaglione; Karolina Szubert; Martin R. Jones; Fabiane Doerr; Elisabeth M.-L. Janssen; Kaarina Sivonen; Mariana Andrade Torres; Christopher O. Miles; David P. Fewer; Carmela Dell’Aversano; Daniel G. Beach; Ernani Pinto
Publié dans: Numéro 3, 2020
Éditeur: BioRxiv
DOI: 10.1101/2020.04.16.038703