Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

Project Information

Foie Gras

Grant agreement ID: 722619

DOI 10.3030/722619

Project closed

EC signature date 29 August 2016

Start date 1 January 2017

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 202 195,68

EU contribution € 3 202 195,68

Coordinated by

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (17)

"Guidelines #1"

Guidelines on nutritional versus exercise lifestyle education to the general public and patients

Technology application notes

Optimized protocols and technology application notes for: a) Use of mid-range IR profiling in plasma to find NAFLD/NASH specific signatures which can be used for diagnostics. b) Detection of markers of liver necroptosis or miRNA in plasma through specific detection kits.

Final outreach report

A final outreach report, containing a description of all outreach initiatives, with feedback from the public, appropriate metrics, photos (and additional videos) will be prepared by month 54.

Presentation of scientific data (WP4)

Presentation of scientific data in: a) scientific meetings, as oral communications (3 predicted) b) scientific meetings, as poster presentations (3 predicted) c) peer-reviewed manuscripts (4 predicted) The final report at month 54 will include copies of each item.

"Reports on Workshops (#1-4)"

Reports will be produced after each workshop containing the main activities and take home-messages. The time at which these reports will be produced will vary, since they will be included in major meetings in Europe, including the Annual Meeting of the European Society for Clinical investigation.

PhD Theses (WP4)

Three PhD theses (ESR7-9)

Final FOIE GRAS Conference report

Final report of the closing conference of the FOIE GRAS network. Includes summaries of projects from all ESRs.

Reports on Network Schools (NS1-NS4)

Reports will be produced after each network school indicating the activities and summaries of the different lectures/laboratory activities. NS1 - report completed on month 8 NS2 - report completed on month 15 NS3 - report completed on month 18 NS4 - report completed on month 28

Presentation of scientific data (WP2)

Presentation of scientific data in: a) scientific meetings, as oral communications (3 predicted) b) scientific meetings, as poster presentations (3 predicted) c) peer-reviewed manuscripts (4 predicted) The final report at month 54 will include copies of each item.

Presentation of scientific data (WP6)

Presentation of scientific data in: a) scientific meetings, as oral communications (2 predicted) b) scientific meetings, as poster presentations (2 predicted) c) peer-reviewed manuscripts (2 predicted) The final report at month 54 will include copies of each item.

"Threapeutic solution #1"

Document proposing a novel pharmacological approach for NAFLD management based in the use of GLP-1 agonists and DPP4-inhibitors.

Presentation of scientific data (WP5)

Presentation of scientific data in: a) scientific meetings, as oral communications (3 predicted) b) scientific meetings, as poster presentations (3 predicted) c) peer-reviewed manuscripts (4 predicted) The final report at month 54 will include copies of each item.

PhD Theses (WP5)

Three PhD theses (ESR10-12)

PhD theses (WP2)

Three PhD theses (ESR1-3)

PhD Theses (WP3)

Three PhD theses (ESR4-6)

PhD Thesis (WP6)

One PhD thesis (ESR-13)

Presentation of scientific data (WP3)

Presentation of scientific data in: a) scientific meetings, as oral communications (3 predicted) b) scientific meetings, as poster presentations (3 predicted) c) peer-reviewed manuscripts (4 predicted) The final report at month 54 will include copies of each item.

Websites, patent fillings, videos etc. (3)

Comics and animations

During the FOIE GRAS programme, it is expected to produce 5 different comics of different lenghts, as well as 1 video animation for educational purposes. These will focus in distinct topics including diet and incidence of fatty liver disease, healthy lifestyles, basic notions on metabolism, as well as other topics. The animation will be ready by week 42, while comics will be ready on weeks 24, 30, 36, 42, 48.

Intelectual Property Protection

Patents** intestinal permeability assays (WP-3), antibody-based kits for GLP-1 (WP2), human oxidized albumin(WP4) and markers of liver damage (WP3) or IR-based methodologies to stratify NAFLD (WP3). Managed by WP7

FOIE GRAS public website

A public website will be prepared open to the general public and demonstrating the general activities of the consortium plus scientific data originating from the programme biographies from the involved reserachers important links etc

Other (3)

Supervisory Board of the network

Establishment of the Supervisoty Board for the FOIE GRAS consortium

"Sports & public engagement (#1 to #6)"

Events aimed at the general public will be produced in the different countries of the consortium. These may include: 1) Researcher’s Night-like events 2) Visits of researchers to schools 3) Presentations of researchers at science centers 4) Open lab days 5) public health initiatives trough physical activity involving adults and children (e.g. racing, marathons) 6) public awareness in sports, e.g., principal football leagues in the countries involved in the consortium

"Public media dissemination #1 to #8"

We expect that at least 8 diffrent deliverables will be produced based on press reports focusing on particular aspects of the FOIE GRAS research programme. We expect that media outlets will pick up the press releases and perform media articles, including interviews with involved scientists and ESRs.

Publications

Peer reviewed articles (65)

Mitophagy in Cardiovascular Diseases

Author(s): Giampaolo Morciano, Simone Patergnani, Massimo Bonora, Gaia Pedriali, Anna Tarocco, Esmaa Bouhamida, Saverio Marchi, Gina Ancora, Gabriele Anania, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Published in: Journal of Clinical Medicine, Issue 9/3, 2020, Page(s) 892, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9030892

Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury

Author(s): Arnau Panisello-Roselló, Joan Roselló-Catafau
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 4093, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19124093

Multiplying effects of COVID‐19 lockdown on metabolic risk and fatty liver

Author(s): Harshitha Shanmugam, Agostino Di Ciaula, Domenica Maria Di Palo, Emilio Molina‐Molina, Gabriella Garruti, Maria Felicia Faienza, Karel vanErpecum, Piero Portincasa
Published in: European Journal of Clinical Investigation, 2021, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13597

The color of fat and its central role in the development and progression of metabolic diseases

Author(s): Melania Gaggini, Fabrizia Carli, Amalia Gastaldelli
Published in: Hormone Molecular Biology and Clinical Investigation, Issue 31/1, 2017, ISSN 1868-1891
Publisher: Walter de Gruyter GmbH
DOI: 10.1515/hmbci-2017-0060

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

Author(s): Ines C. M. Simoes, Agnieszka Karkucinska-Wieckowska, Justyna Janikiewicz, Sylwia Szymanska, Maciej Pronicki, Pawel Dobrzyn, Michal Dabrowski, Agnieszka Dobrzyn, Paulo J. Oliveira, Hans Zischka, Yaiza Potes, Mariusz R. Wieckowski
Published in: Antioxidants, Issue 9/10, 2020, Page(s) 995, ISSN 2076-3921
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox9100995

New Insights in Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury 2.0: An Updated Overview

Author(s): Arnau Panisello-Roselló, Joan Roselló-Catafau, René Adam
Published in: International Journal of Molecular Sciences, Issue 22/1, 2021, Page(s) 28, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010028

Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver

Author(s): Agostino Di Ciaula, Federico Carbone, Harshitha Shanmugham, Emilio Molina-Molina, Leonilde Bonfrate, Stefano Ministrini, Fabrizio Montecucco, Piero Portincasa
Published in: European Journal of Internal Medicine, 2021, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2021.03.036

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Author(s): Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinton, Yaiza Potes, Mariusz R. Wieckowski
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1866/10, 2020, Page(s) 165834, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2020.165834

Aging and nutrition. Paving the way to better health

Author(s): Emilio Molina-Molina, Gabriella Garruti, Harshitha Shanmugam, Domenica Maria Di Palo, Ignazio Grattagliano, Tecla Mastronuzzi, Piero Portincasa
Published in: Romanian Journal of Internal Medicine, Issue 58/2, 2020, Page(s) 55-68, ISSN 2501-062X
Publisher: Sciendo
DOI: 10.2478/rjim-2020-0005

Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine

Author(s): Elena Grasselli, Laura Canesi, Piero Portincasa, Adriana Voci, Laura Vergani, Ilaria Demori
Published in: Annals of Hepatology, Issue 16/5, 2017, Page(s) 707-719, ISSN 1665-2681
Publisher: Ediciones Medicina y Cultura
DOI: 10.5604/01.3001.0010.2713

Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring

Author(s): Jelena Stevanović-Silva, Jorge Beleza, Pedro Coxito, Susana Pereira, Hugo Rocha, Tiago Bordeira Gaspar, Fátima Gärtner, Rossana Correia, Maria João Martins, Tiago Guimarães, Sandra Martins, Paulo J. Oliveira, António Ascensão, José Magalhães
Published in: Metabolism, Issue 116, 2021, Page(s) 154704, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2021.154704

Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

Author(s): Federico Carbone, Maria Stefania Lattanzio, Silvia Minetti, Anna Maria Ansaldo, Daniele Ferrara, Emilio Molina-Molina, Anna Belfiore, Edoardo Elia, Stefania Pugliese, Vincenzo Ostilio Palmieri, Fabrizio Montecucco, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 20/23, 2019, Page(s) 5981, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20235981

Insulin resistance, but not insulin response, during oral glucose tolerance test (OGTT) is associated to worse histological outcome in obese NAFLD

Author(s): Federica Coccia, Moira Testa, Gloria Guarisco, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Amalia Gastaldelli, Danila Capoccia
Published in: Nutrition, Metabolism and Cardiovascular Diseases, Issue 30/1, 2020, Page(s) 106-113, ISSN 0939-4753
Publisher: Medikal Press s.r.l.
DOI: 10.1016/j.numecd.2019.08.001

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile

Author(s): Piero Portincasa, Karel J van Erpecum, Agostino Di Ciaula, David Q -H Wang
Published in: Gastroenterology Report, Issue 7/1, 2018, Page(s) 32-41, ISSN 2052-0034
Publisher: Oxford University Press
DOI: 10.1093/gastro/goy044

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Author(s): Massimo Bonora, Simone Patergnani, Daniela Ramaccini, Giampaolo Morciano, Gaia Pedriali, Asrat Endrias Kahsay, Esmaa Bouhamida, Carlotta Giorgi, Mariusz R. Wieckowski, Paolo Pinton
Published in: Biomolecules, Issue 10/7, 2020, Page(s) 998, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom10070998

Lytic cell death in metabolic liver disease

Author(s): Jérémie Gautheron, Gregory J. Gores, Cecília M.P. Rodrigues
Published in: Journal of Hepatology, Issue 73/2, 2020, Page(s) 394-408, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.001

Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis

Author(s): Claudia Morganti, Sonia Missiroli, Magdalena Lebiedzinska-Arciszewska, Letizia Ferroni, Lucia Morganti, Mariasole Perrone, Daniela Ramaccini, Savino Occhionorelli, Barbara Zavan, Mariusz R. Wieckowski, Carlotta Giorgi
Published in: International Journal of Obesity, Issue 43/5, 2019, Page(s) 963-973, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-018-0167-1

(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle

Author(s): Emilio Molina-Molina, Harshitha Shanmugam, Agostino Di Ciaula, Ignazio Grattagliano, Domenica Maria Di Palo, Vincenzo O. Palmieri, Piero Portincasa
Published in: JHEP Reports, Issue 3/1, 2021, Page(s) 100203, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2020.100203

Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases

Author(s): Inês Marques-Aleixo, Jorge Beleza, Arnaldina Sampaio, Jelena Stevanović, Pedro Coxito, Inês Gonçalves, António Ascensão, José Magalhães
Published in: Antioxidants & Redox Signaling, Issue 34/8, 2021, Page(s) 674-693, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2020.8075

Anti‐ApoA‐1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Author(s): Federico Carbone, Agostino Di Ciaula, Sabrina Pagano, Silvia Minetti, Anna Maria Ansaldo, Daniele Ferrara, Anna Belfiore, Edoardo Elia, Stefania Pugliese, Vincenzo Ostilio Palmieri, Fabrizio Montecucco, Nicolas Vuilleumier, Piero Portincasa
Published in: European Journal of Clinical Investigation, Issue 51/3, 2021, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13410

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Author(s): Arnau Panisello-Roselló, Eva Verde, Alexandre Lopez, Marta Flores, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, Georgina Hotter, Teresa Carbonell, René Adam, Joan Roselló-Catafau
Published in: International Journal of Molecular Sciences, Issue 19/2, 2018, Page(s) 348, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020348

Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis

Author(s): Domenica Maria Di Palo, Gabriella Garruti, Agostino Di Ciaula, Emilio Molina-Molina, Harshitha Shanmugam, Maria De Angelis, Piero Portincasa
Published in: Nutrients, Issue 12/2, 2020, Page(s) 564, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12020564

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Author(s): Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Published in: Molecular Metabolism, Issue 32, 2020, Page(s) 1-14, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.015

Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?

Author(s): Agostino Di Ciaula, Salvatore Passarella, Harshitha Shanmugam, Marica Noviello, Leonilde Bonfrate, David Q.-H. Wang, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5375, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105375

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Author(s): Harshitha Shanmugam, Emilio Molina Molina, Domenica Maria Di Palo, Maria Felicia Faienza, Agostino Di Ciaula, Gabriella Garruti, David Q. H. Wang, Piero Portincasa
Published in: Journal of Gastrointestinal and Liver Diseases, Issue 29/1, 2020, Page(s) 99-110, ISSN 1841-8724
Publisher: Editura Medicala
DOI: 10.15403/jgld-544

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Author(s): Meneses, Silvestre, Sousa-Lima, Macedo
Published in: International Journal of Molecular Sciences, Issue 20/16, 2019, Page(s) 4049, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20164049

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Author(s): Inês C. M. Simões, Ricardo Amorim, José Teixeira, Agnieszka Karkucinska-Wieckowska, Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes, Mariusz R. Wieckowski
Published in: International Journal of Molecular Sciences, Issue 22/13, 2021, Page(s) 6848, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136848

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Author(s): Ricardo Amorim, Inês C. M. Simões, Caroline Veloso, Adriana Carvalho, Rui F. Simões, Francisco B. Pereira, Theresa Thiel, Andrea Normann, Catarina Morais, Amália S. Jurado, Mariusz R. Wieckowski, José Teixeira, Paulo J. Oliveira
Published in: Nutrients, Issue 13/5, 2021, Page(s) 1723, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13051723

Mitochondria in non-alcoholic fatty liver disease

Author(s): Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Published in: The International Journal of Biochemistry & Cell Biology, Issue 95, 2018, Page(s) 93-99, ISSN 1357-2725
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biocel.2017.12.019

Exercising the hepatobiliary-gut axis. The impact of physical activity performance

Author(s): Emilio Molina-Molina, Raquel Lunardi Baccetto, David Q-H Wang, Ornella de Bari, Marcin Krawczyk, Piero Portincasa
Published in: European Journal of Clinical Investigation, 2018, Page(s) e12958, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.12958

Bile Acid Physiology

Author(s): Agostino Di Ciaula, Gabriella Garruti, Raquel Lunardi Baccetto, Emilio Molina-Molina, Leonilde Bonfrate, David Q-H Wang, Piero Portincasa
Published in: Annals of Hepatology, Issue 16/0, 2017, Page(s) 4-14, ISSN 1665-2681
Publisher: Ediciones Medicina y Cultura
DOI: 10.5604/01.3001.0010.5493

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury

Author(s): Arnau Panisello-Roselló, Norma Alva, Marta Flores, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, René Adam, Teresa Carbonell, Joan Roselló-Catafau
Published in: International Journal of Molecular Sciences, Issue 19/9, 2018, Page(s) 2479, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19092479

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Author(s): Arnau Panisello-Roselló, Alexandre Lopez, Emma Folch-Puy, Teresa Carbonell, Anabela Rolo, Carlos Palmeira, René Adam, Marc Net, Joan Roselló-Catafau
Published in: World Journal of Gastroenterology, Issue 24/27, 2018, Page(s) 2984-2994, ISSN 1007-9327
Publisher: W J G Press
DOI: 10.3748/wjg.v24.i27.2984

Bile Acids and Cancer: Direct and Environmental-Dependent Effects

Author(s): Agostino Di Ciaula, David Q.-H. Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O. Palmieri, Piero Portincasa
Published in: Annals of Hepatology, Issue 16/0, 2017, Page(s) 81-99, ISSN 1665-2681
Publisher: Ediciones Medicina y Cultura
DOI: 10.5604/01.3001.0010.5501

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Author(s): Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, John G. Jones
Published in: Magnetic Resonance in Medicine, Issue 81/1, 2019, Page(s) 639-644, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27378

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Author(s): Hu Huang, Seung-Hwan Lee, Inês Sousa-Lima, Sang Soo Kim, Won Min Hwang, Yossi Dagon, Won-Mo Yang, Sungman Cho, Min-Cheol Kang, Ji A. Seo, Munehiko Shibata, Hyunsoo Cho, Getachew Debas Belew, Jinhyuk Bhin, Bhavna N. Desai, Min Jeong Ryu, Minho Shong, Peixin Li, Hua Meng, Byung-Hong Chung, Daehee Hwang, Min Seon Kim, Kyong Soo Park, Maria Paula Macedo, Morris White, John Jones, Young-Bum Kim
Published in: Journal of Clinical Investigation, Issue 128/12, 2018, Page(s) 5335-5350, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci63562

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Author(s): Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Published in: Hepatology Communications, Issue 2/9, 2018, Page(s) 1080-1094, ISSN 2471-254X
Publisher: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Author(s): Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Published in: Biochemical Pharmacology, Issue 160, 2019, Page(s) 34-45, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2018.11.020

Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution Appraisal

Author(s): A. Panisello-Rosello, C. Castro-Benítez, A. Lopez, S. Balloji, E. Folch-Puy, R. Adam, J. Roselló-Catafau
Published in: Transplantation Proceedings, Issue 50/3, 2018, Page(s) 714-718, ISSN 0041-1345
Publisher: Appleton & Lange
DOI: 10.1016/j.transproceed.2018.02.044

Critical Care Aspects of Gallstone Disease

Author(s): Piero Portincasa, Emilio Molina-Molina, Gabriella Garruti, David Q.-H. Wang
Published in: The Journal of Critical Care Medicine, Issue 5/1, 2019, Page(s) 6-18, ISSN 2393-1817
Publisher: University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș
DOI: 10.2478/jccm-2019-0003

Gastrointestinal defects in gallstone and cholecystectomized patients

Author(s): Agostino Di Ciaula, Emilio Molina-Molina, Leonilde Bonfrate, David Q.-H. Wang, Dan L. Dumitrascu, Piero Portincasa
Published in: European Journal of Clinical Investigation, Issue 49/3, 2019, Page(s) e13066, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13066

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Author(s): Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00593

Faster Detection of Helicobacter pylori Infection by 13 C-Urea Breath Test. Comparing Short versus Standard Sampling Time

Author(s): Emilio Molina-Molina, Leonilde Bonfrate, Michele Lorusso, Harshitha Shanmugam, Giuseppe Scaccianoce, Theodore Rokkas, Piero Portincasa
Published in: Journal of Gastrointestinal and Liver Diseases, Issue 28, 2019, Page(s) 151-161, ISSN 1841-8724
Publisher: Editura Medicala
DOI: 10.15403/jgld-175

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Author(s): Martina Theresa Hackl, Clemens Fürnsinn, Christina Maria Schuh, Martin Krssak, Fabrizia Carli, Sara Guerra, Angelika Freudenthaler, Sabina Baumgartner-Parzer, Thomas H. Helbich, Anton Luger, Maximilian Zeyda, Amalia Gastaldelli, Christoph Buettner, Thomas Scherer
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10684-1

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Author(s): Adriana Fontes, Mireia Alemany-Pagès, Paulo J. Oliveira, João Ramalho-Santos, Hans Zischka, Anabela Marisa Azul
Published in: International Journal of Molecular Sciences, Issue 20/16, 2019, Page(s) 3987, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20163987

Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis

Author(s): Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones
Published in: Journal of Lipid Research, 2019, Page(s) jlr.RA119000354, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1194/jlr.ra119000354

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Author(s): Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Published in: Cells, Issue 8/10, 2019, Page(s) 1222, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8101222

Non-Alcoholic Fatty Liver Disease in Non-Obese Individuals: Prevalence, Pathogenesis and Treatment

Author(s): Emilio Molina-Molina, Marcin Krawczyk, Ewa Stachowska, Frank Lammert, Piero Portincasa
Published in: Clinics and Research in Hepatology and Gastroenterology, Issue 43/6, 2019, Page(s) 638-645, ISSN 2210-7401
Publisher: Elsevier Masson
DOI: 10.1016/j.clinre.2019.04.005

Physical Activity is Beneficial for Gallbladder Disease

Author(s): Molina-Molina E, Shanmugam H,Wang DQH, Vergani L, Portincasa P.
Published in: Japanese Journal of Gastroenterology and Hepatology, Issue 1(1), 2019, Page(s) 1-4, ISSN 2435-1210
Publisher: Independent Jouranl

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Author(s): Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Published in: Nutrients, Issue 11/12, 2019, Page(s) 2871, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11122871

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

Author(s): Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron
Published in: Journal of Hepatology, 2019, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.11.008

Childhood obesity, cardiovascular and liver health: a growing epidemic with age

Author(s): Maria Felicia Faienza, Mariangela Chiarito, Emilio Molina-Molina, Harshitha Shanmugam, Frank Lammert, Marcin Krawczyk, Gabriele D’Amato, Piero Portincasa
Published in: World Journal of Pediatrics, 2020, ISSN 1708-8569
Publisher: Springer Verlag
DOI: 10.1007/s12519-020-00341-9

Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance?

Author(s): Mireia Alemany-Pagès, Mariana Moura-Ramos, Sara Araújo, Maria Paula Macedo, Rogério T. Ribeiro, Dulce do Ó, João Ramalho-Santos, Anabela Marisa Azul
Published in: BMC Public Health, Issue 20/1, 2020, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-020-09249-5

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Author(s): Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares, John G. Jones
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69820-3

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Author(s): Gianluca Svegliati-Baroni, Bárbara Patrício, Gessica Lioci, Maria Paula Macedo, Amalia Gastaldelli
Published in: International Journal of Molecular Sciences, Issue 21/16, 2020, Page(s) 5820, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165820

Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation

Author(s): Arnau Panisello Rosello, Rui Teixeira da Silva, Carlos Castro, Raquel G. Bardallo, Maria Calvo, Emma Folch-Puy, Teresa Carbonell, Carlos Palmeira, Joan Roselló Catafau, René Adam
Published in: International Journal of Molecular Sciences, Issue 21/16, 2020, Page(s) 5703, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165703

The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes

Author(s): Sara Guerra, Amalia Gastaldelli
Published in: Current Opinion in Pharmacology, Issue 55, 2020, Page(s) 165-174, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2020.10.016

Building‐up fit muscles for the future

Author(s): Jorge Beleza, Jelena Stevanović‐Silva, Pedro Coxito, Rui Carlos Costa, António Ascensão, Joan Ramon Torrella, José Magalhães
Published in: European Journal of Clinical Investigation, 2021, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13515

A Mitochondrial Approach to Cardiovascular Risk and Disease

Author(s): Caroline D. Veloso, Getachew D. Belew, Luciana L. Ferreira, Luís F. Grilo, John G. Jones, Piero Portincasa, Vilma A. Sardão, Paulo J. Oliveira
Published in: Current Pharmaceutical Design, Issue 25/29, 2019, Page(s) 3175-3194, ISSN 1381-6128
Publisher: Bentham Science Publishers
DOI: 10.2174/1389203720666190830163735

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Author(s): Alessandro Rimessi, Gaia Pedriali, Bianca Vezzani, Anna Tarocco, Saverio Marchi, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Published in: Seminars in Cell & Developmental Biology, Issue 98, 2020, Page(s) 167-180, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.05.015

Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

Author(s): Gabriella Sistilli, Veronika Kalendova, Tomas Cajka, Illaria Irodenko, Kristina Bardova, Marina Oseeva, Petr Zacek, Petra Kroupova, Olga Horakova, Karoline Lackner, Amalia Gastaldelli, Ondrej Kuda, Jan Kopecky, Martin Rossmeisl
Published in: Nutrients, Issue 13/2, 2021, Page(s) 437, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13020437

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Author(s): Gaia Pedriali, Giampaolo Morciano, Simone Patergnani, Paolo Cimaglia, Cristina Morelli, Elisa Mikus, Roberto Ferrari, Vincenzo Gasbarro, Carlotta Giorgi, Mariusz R. Wieckowski, Paolo Pinton
Published in: International Journal of Molecular Sciences, Issue 21/14, 2020, Page(s) 4899, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21144899

Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach

Author(s): Raquel G. Bardallo, Rui Teixeira da Silva, Teresa Carbonell, Emma Folch-Puy, Carlos Palmeira, Joan Roselló-Catafau, Jacques Pirenne, René Adam, Arnau Panisello-Roselló
Published in: International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5332, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105332

Mechanisms for increased risk of diabetes in chronic liver diseases

Author(s): Gianluca Svegliati‐Baroni, Melania Gaggini, Fabrizia Carli, Chiara Barbieri, Monica Cucco, Ramy Younes, Chiara Rosso, Elisabetta Bugianesi, Amalia Gastaldelli
Published in: Liver International, Issue 40/10, 2020, Page(s) 2489-2499, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14556

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C‐isotopomers derived from [U‐ 13 C]fructose and [U‐ 13 C]glucose

Author(s): Getachew D. Belew, Giada Di Nunzio, Ludgero Tavares, Joao G. Silva, Alejandra N. Torres, John G. Jones
Published in: Magnetic Resonance in Medicine, Issue 84/5, 2020, Page(s) 2765-2771, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28286

Other (10)

¡Un hígado equilibrado es medio camino andado!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2115-9
Publisher: Coimbra University Press

Um Fígado Equilibrado é Meio Caminho Andado!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2039-8
Publisher: Coimbra University Press

Eine gesunde Leber – nicht nur was für Streber!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2119-7
Publisher: Coimbra University Press

Sigues metge del teu propi fetge!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2117-3
Publisher: Coimbra University Press

Publicly stressing the role of mitochondria in NAFLD with(in) a sports event

Author(s): Mireia Alemany‐Pagès Rui Tavares Sara Varela Amaral Ana Teresa Barros-Viegas Paulo J. Oliveira João Ramalho‐Santos Anabela Marisa Azul
Published in: European Journal of Clinical Investigation, Issue 50(5), 2021, ISSN 1365-2362
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/eci.13234

Un Fegato Sano Ti Porta Lontano!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2121-0
Publisher: Coimbra University Press

Zdrowa wątroba przy długim życiu Cię zachowa!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2127-2
Publisher: Coimbra University Press

Zdravá játra vždy splní své povinnosti!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2129-6
Publisher: Coimbra University Press

Healthy Liver Will Always Deliver!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2042-8
Publisher: Coimbra University Press

La prochaine fois, pensez à ton foie!

Author(s): Alemany i Pagès M, Ramalho-Santos J, Tavares R, Azul A M.
Published in: 2020, ISBN 978-989-26-2123-4
Publisher: Coimbra University Press

Book chapters (2)

The role of mitochondria-associated membranes in cellular homeostasis and diseases

Author(s): Mariasole Perrone, Natascia Caroccia, Ilaria Genovese, Sonia Missiroli, Lorenzo Modesti, Gaia Pedriali, Bianca Vezzani, Veronica Angela Maria Vitto, Michele Antenori, Magdalena Lebiedzinska-Arciszewska, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Published in: Biology of the Endoplasmic Reticulum, Issue 350, 2020, Page(s) 119-196, ISBN 9780128197448
Publisher: Elsevier
DOI: 10.1016/bs.ircmb.2019.11.002

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Author(s): Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Published in: Mitochondria and Longevity, Issue 340, 2018, Page(s) 209-344, ISBN 9780-128157367
Publisher: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

Intellectual Property Rights

Patent (4)

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 809369
Date: 2017-10-16
Applicant(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 835943
Date: 2017-12-29
Applicant(s): UNIVERSIDADE DO PORTO

HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 809369
Date: 2017-10-16
Applicant(s): UNIVERSIDADE DO PORTO

HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF

Application/Publication number: 17 835943
Date: 2017-12-29
Applicant(s): CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO