Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

Deliverables

Establishment of the Supervisoty Board for the FOIE GRAS consortium

A public website will be prepared, open to the general public and demonstrating the general activities of the consortium, plus scientific data originating from the programme, biographies from the involved reserachers, important links, etc.

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Publications

Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury

Author(s): Arnau Panisello-Roselló, Joan Roselló-Catafau
Published in: International Journal of Molecular Sciences, Issue 19/12, 2018, Page(s) 4093, ISSN 1422-0067
DOI: 10.3390/ijms19124093

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Author(s): Ines C.M. Simoes, Giampaolo Morciano, Magdalena Lebiedzinska-Arciszewska, Gianluca Aguiari, Paolo Pinton, Yaiza Potes, Mariusz R. Wieckowski
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1866/10, 2020, Page(s) 165834, ISSN 0925-4439
DOI: 10.1016/j.bbadis.2020.165834

Aging and nutrition. Paving the way to better health

Author(s): Emilio Molina-Molina, Gabriella Garruti, Harshitha Shanmugam, Domenica Maria Di Palo, Ignazio Grattagliano, Tecla Mastronuzzi, Piero Portincasa
Published in: Romanian Journal of Internal Medicine, Issue 58/2, 2020, Page(s) 55-68, ISSN 2501-062X
DOI: 10.2478/rjim-2020-0005

Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

Author(s): Federico Carbone, Maria Stefania Lattanzio, Silvia Minetti, Anna Maria Ansaldo, Daniele Ferrara, Emilio Molina-Molina, Anna Belfiore, Edoardo Elia, Stefania Pugliese, Vincenzo Ostilio Palmieri, Fabrizio Montecucco, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 20/23, 2019, Page(s) 5981, ISSN 1422-0067
DOI: 10.3390/ijms20235981

Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis

Author(s): Domenica Maria Di Palo, Gabriella Garruti, Agostino Di Ciaula, Emilio Molina-Molina, Harshitha Shanmugam, Maria De Angelis, Piero Portincasa
Published in: Nutrients, Issue 12/2, 2020, Page(s) 564, ISSN 2072-6643
DOI: 10.3390/nu12020564

Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Author(s): Jelena Stevanović, Jorge Beleza, Pedro Coxito, António Ascensão, José Magalhães
Published in: Molecular Metabolism, Issue 32, 2020, Page(s) 1-14, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.11.015

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Author(s): Harshitha Shanmugam, Emilio Molina Molina, Domenica Maria Di Palo, Maria Felicia Faienza, Agostino Di Ciaula, Gabriella Garruti, David Q. H. Wang, Piero Portincasa
Published in: Journal of Gastrointestinal and Liver Diseases, Issue 29/1, 2020, Page(s) 99-110, ISSN 1841-8724
DOI: 10.15403/jgld-544

Mitochondria in non-alcoholic fatty liver disease

Author(s): Inês C.M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka, Mariusz R. Wieckowski
Published in: The International Journal of Biochemistry & Cell Biology, Issue 95, 2018, Page(s) 93-99, ISSN 1357-2725
DOI: 10.1016/j.biocel.2017.12.019

Exercising the hepatobiliary-gut axis. The impact of physical activity performance

Author(s): Emilio Molina-Molina, Raquel Lunardi Baccetto, David Q-H Wang, Ornella de Bari, Marcin Krawczyk, Piero Portincasa
Published in: European Journal of Clinical Investigation, 2018, Page(s) e12958, ISSN 0014-2972
DOI: 10.1111/eci.12958

Bile Acid Physiology

Author(s): Agostino Di Ciaula, Gabriella Garruti, Raquel Lunardi Baccetto, Emilio Molina-Molina, Leonilde Bonfrate, David Q-H Wang, Piero Portincasa
Published in: Annals of Hepatology, Issue 16/0, 2017, Page(s) 4-14, ISSN 1665-2681
DOI: 10.5604/01.3001.0010.5493

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury

Author(s): Arnau Panisello-Roselló, Norma Alva, Marta Flores, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, René Adam, Teresa Carbonell, Joan Roselló-Catafau
Published in: International Journal of Molecular Sciences, Issue 19/9, 2018, Page(s) 2479, ISSN 1422-0067
DOI: 10.3390/ijms19092479

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Author(s): Arnau Panisello-Roselló, Alexandre Lopez, Emma Folch-Puy, Teresa Carbonell, Anabela Rolo, Carlos Palmeira, René Adam, Marc Net, Joan Roselló-Catafau
Published in: World Journal of Gastroenterology, Issue 24/27, 2018, Page(s) 2984-2994, ISSN 1007-9327
DOI: 10.3748/wjg.v24.i27.2984

Bile Acids and Cancer: Direct and Environmental-Dependent Effects

Author(s): Agostino Di Ciaula, David Q.-H. Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O. Palmieri, Piero Portincasa
Published in: Annals of Hepatology, Issue 16/0, 2017, Page(s) 81-99, ISSN 1665-2681
DOI: 10.5604/01.3001.0010.5501

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Author(s): Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, John G. Jones
Published in: Magnetic Resonance in Medicine, Issue 81/1, 2019, Page(s) 639-644, ISSN 0740-3194
DOI: 10.1002/mrm.27378

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Author(s): Hu Huang, Seung-Hwan Lee, Inês Sousa-Lima, Sang Soo Kim, Won Min Hwang, Yossi Dagon, Won-Mo Yang, Sungman Cho, Min-Cheol Kang, Ji A. Seo, Munehiko Shibata, Hyunsoo Cho, Getachew Debas Belew, Jinhyuk Bhin, Bhavna N. Desai, Min Jeong Ryu, Minho Shong, Peixin Li, Hua Meng, Byung-Hong Chung, Daehee Hwang, Min Seon Kim, Kyong Soo Park, Maria Paula Macedo, Morris White, John Jones, Young-Bum Kim
Published in: Journal of Clinical Investigation, Issue 128/12, 2018, Page(s) 5335-5350, ISSN 0021-9738
DOI: 10.1172/jci63562

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Author(s): Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Published in: Hepatology Communications, Issue 2/9, 2018, Page(s) 1080-1094, ISSN 2471-254X
DOI: 10.1002/hep4.1225

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Author(s): Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Published in: Biochemical Pharmacology, Issue 160, 2019, Page(s) 34-45, ISSN 0006-2952
DOI: 10.1016/j.bcp.2018.11.020

Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution Appraisal

Author(s): A. Panisello-Rosello, C. Castro-Benítez, A. Lopez, S. Balloji, E. Folch-Puy, R. Adam, J. Roselló-Catafau
Published in: Transplantation Proceedings, Issue 50/3, 2018, Page(s) 714-718, ISSN 0041-1345
DOI: 10.1016/j.transproceed.2018.02.044

Critical Care Aspects of Gallstone Disease

Author(s): Piero Portincasa, Emilio Molina-Molina, Gabriella Garruti, David Q.-H. Wang
Published in: The Journal of Critical Care Medicine, Issue 5/1, 2019, Page(s) 6-18, ISSN 2393-1817
DOI: 10.2478/jccm-2019-0003

Gastrointestinal defects in gallstone and cholecystectomized patients

Author(s): Agostino Di Ciaula, Emilio Molina-Molina, Leonilde Bonfrate, David Q.-H. Wang, Dan L. Dumitrascu, Piero Portincasa
Published in: European Journal of Clinical Investigation, Issue 49/3, 2019, Page(s) e13066, ISSN 0014-2972
DOI: 10.1111/eci.13066

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Author(s): Jorge Beleza, João Albuquerque, Estela Santos-Alves, Pedro Fonseca, Garoa Santocildes, Jelena Stevanovic, Sílvia Rocha-Rodrigues, David Rizo-Roca, António Ascensão, Joan Ramon Torrella, José Magalhães
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
DOI: 10.3389/fphys.2019.00593

Faster Detection of Helicobacter pylori Infection by 13 C-Urea Breath Test. Comparing Short versus Standard Sampling Time

Author(s): Emilio Molina-Molina, Leonilde Bonfrate, Michele Lorusso, Harshitha Shanmugam, Giuseppe Scaccianoce, Theodore Rokkas, Piero Portincasa
Published in: Journal of Gastrointestinal and Liver Diseases, Issue 28, 2019, Page(s) 151-161, ISSN 1841-8724
DOI: 10.15403/jgld-175

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Author(s): Martina Theresa Hackl, Clemens Fürnsinn, Christina Maria Schuh, Martin Krssak, Fabrizia Carli, Sara Guerra, Angelika Freudenthaler, Sabina Baumgartner-Parzer, Thomas H. Helbich, Anton Luger, Maximilian Zeyda, Amalia Gastaldelli, Christoph Buettner, Thomas Scherer
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-10684-1

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Author(s): Adriana Fontes, Mireia Alemany-Pagès, Paulo J. Oliveira, João Ramalho-Santos, Hans Zischka, Anabela Marisa Azul
Published in: International Journal of Molecular Sciences, Issue 20/16, 2019, Page(s) 3987, ISSN 1422-0067
DOI: 10.3390/ijms20163987

Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis

Author(s): Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones
Published in: Journal of Lipid Research, 2019, Page(s) jlr.RA119000354, ISSN 0022-2275
DOI: 10.1194/jlr.ra119000354

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Author(s): Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
Published in: Cells, Issue 8/10, 2019, Page(s) 1222, ISSN 2073-4409
DOI: 10.3390/cells8101222

Non-Alcoholic Fatty Liver Disease in Non-Obese Individuals: Prevalence, Pathogenesis and Treatment

Author(s): Emilio Molina-Molina, Marcin Krawczyk, Ewa Stachowska, Frank Lammert, Piero Portincasa
Published in: Clinics and Research in Hepatology and Gastroenterology, Issue 43/6, 2019, Page(s) 638-645, ISSN 2210-7401
DOI: 10.1016/j.clinre.2019.04.005

Physical Activity is Beneficial for Gallbladder Disease

Author(s): Molina-Molina E, Shanmugam H,Wang DQH, Vergani L, Portincasa P.
Published in: Japanese Journal of Gastroenterology and Hepatology, Issue 1(1), 2019, Page(s) 1-4, ISSN 2435-1210

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Author(s): Simoes, Janikiewicz, Bauer, Karkucinska-Wieckowska, Kalinowski, Dobrzyń, Wolski, Pronicki, Zieniewicz, Dobrzyń, Krawczyk, Zischka, Wieckowski, Potes
Published in: Nutrients, Issue 11/12, 2019, Page(s) 2871, ISSN 2072-6643
DOI: 10.3390/nu11122871

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

Author(s): Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron
Published in: Journal of Hepatology, 2019, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.11.008

Childhood obesity, cardiovascular and liver health: a growing epidemic with age

Author(s): Maria Felicia Faienza, Mariangela Chiarito, Emilio Molina-Molina, Harshitha Shanmugam, Frank Lammert, Marcin Krawczyk, Gabriele D’Amato, Piero Portincasa
Published in: World Journal of Pediatrics, 2020, ISSN 1708-8569
DOI: 10.1007/s12519-020-00341-9

Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance?

Author(s): Mireia Alemany-Pagès, Mariana Moura-Ramos, Sara Araújo, Maria Paula Macedo, Rogério T. Ribeiro, Dulce do Ó, João Ramalho-Santos, Anabela Marisa Azul
Published in: BMC Public Health, Issue 20/1, 2020, ISSN 1471-2458
DOI: 10.1186/s12889-020-09249-5

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

Author(s): Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares, John G. Jones
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-69820-3

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Author(s): Gianluca Svegliati-Baroni, Bárbara Patrício, Gessica Lioci, Maria Paula Macedo, Amalia Gastaldelli
Published in: International Journal of Molecular Sciences, Issue 21/16, 2020, Page(s) 5820, ISSN 1422-0067
DOI: 10.3390/ijms21165820

Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation

Author(s): Arnau Panisello Rosello, Rui Teixeira da Silva, Carlos Castro, Raquel G. Bardallo, Maria Calvo, Emma Folch-Puy, Teresa Carbonell, Carlos Palmeira, Joan Roselló Catafau, René Adam
Published in: International Journal of Molecular Sciences, Issue 21/16, 2020, Page(s) 5703, ISSN 1422-0067
DOI: 10.3390/ijms21165703

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Author(s): Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Published in: Mitochondria and Longevity, Issue 340, 2018, Page(s) 209-344
DOI: 10.1016/bs.ircmb.2018.05.006

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