Deliverables Other (4) Scientific publications Task 5.6: Publish research findings (leads: all beneficiaries). Direct interaction with the public Task 5.3: Perform public outreach activities (all ESRs; lead: B7-UNIGE). Presentations at scientific conferences Task 5.5: Present research findings at international scientific conferences (leads: all beneficiaries). Press releases Task 5.4: Produce press releases (lead: B6-UOXF) Websites, patent fillings, videos etc. (1) SYNTRAIN website Task 5.1: Establishment of SYNTRAIN website (lead: B1-UCPH). Documents, reports (2) International scientific conference Task 4.5: Organization of international scientific conference (leads: B3-UPAT and B5-DCS). PhD theses Task 4.6: Awarding of doctoral degrees (leads: all beneficiaries). Publications Peer reviewed articles (18) Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination Author(s): Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-06287-x Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum Author(s): Jemina Lehto, Anna Huguet Ninou, Dimitrios Chioureas, Jos Jonkers, Nina M. S. Gustafsson Published in: Cancers, Issue 13/6, 2021, Page(s) 1442, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13061442 OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions Author(s): Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz Published in: Biomolecules, Issue 10/11, 2020, Page(s) 1483, ISSN 2218-273X Publisher: Biomolecules DOI: 10.3390/biom10111483 Targeting OGG1 arrests cancer cell proliferation by inducing replication stress Author(s): Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero, Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita, Evert J Homan, Stella Kar Published in: Nucleic Acids Research, 2020, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkaa1048 Cellular senescence and failure of myelin repair in multiple sclerosis Author(s): Paraskevi N. Koutsoudaki, Dimitrios Papadopoulos, Panagiotis-Georgios Passias, Pinelopi Koutsoudaki, Vassilis G. Gorgoulis Published in: Mechanisms of Ageing and Development, Issue 192, 2020, Page(s) 111366, ISSN 0047-6374 Publisher: Elsevier BV DOI: 10.1016/j.mad.2020.111366 DNA Damage and Cancer Immunotherapy: A STING in the Tale Author(s): Timo Reisländer, Florian J. Groelly, Madalena Tarsounas Published in: Molecular Cell, Issue 80/1, 2020, Page(s) 21-28, ISSN 1097-2765 Publisher: Cell Press DOI: 10.1016/j.molcel.2020.07.026 Mitochondrial Homeostasis and Cellular Senescence Author(s): Panagiotis Vasileiou, Konstantinos Evangelou, Konstantinos Vlasis, Georgios Fildisis, Mihalis Panayiotidis, Efstathios Chronopoulos, Panagiotis-Georgios Passias, Mirsini Kouloukoussa, Vassilis Gorgoulis, Sophia Havaki Published in: Cells, Issue 8/7, 2019, Page(s) 686, ISSN 2073-4409 Publisher: Cells DOI: 10.3390/cells8070686 Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation Author(s): Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina v Published in: Science, Issue 362/6416, 2018, Page(s) 834-839, ISSN 0036-8075 Publisher: American Association for the Advancement of Science DOI: 10.1126/science.aar8048 Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability Author(s): Reihaneh Zarrizi, Martin R. Higgs, Karolin Voßgröne, Maria Rossing, Birgitte Bertelsen, Muthiah Bose, Arne Nedergaard Kousholt, Heike Rösner, the COMPLEXO Network, Bent Ejlertsen, Grant S. Stewart, Finn Cilius Nielsen, Claus S. Sørensen Published in: Journal of Clinical Investigation, Issue bi weekly, 2020, Page(s) 4069-4080, ISSN 0021-9738 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci127521 Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses Author(s): Marianna Tampere, Aleksandra Pettke, Cristiano Salata, Olov Wallner, Tobias Koolmeister, Armando Cazares-Körner, Torkild Visnes, Maria Carmen Hesselman, Elena Kunold, Elisee Wiita, Christina Kalderén, Molly Lightowler, Ann-Sofie Jemth, Janne Lehtiö, Åsa Rosenquist, Ulrika Warpman-Berglund, Thomas Helleday, Ali Mirazimi, Rozbeh Jafari, Marjo-Riitta Puumalainen Published in: Viruses, Issue 12/12, 2020, Page(s) 1423, ISSN 1999-4915 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/v12121423 Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance Author(s): Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas Published in: EMBO Molecular Medicine, Issue 11/7, 2019, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201809982 A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence Author(s): Eirini-Stavroula Komseli, Ioannis S. Pateras, Thorbjørn Krejsgaard, Konrad Stawiski, Sophia V. Rizou, Alexander Polyzos, Fani-Marlen Roumelioti, Maria Chiourea, Ioanna Mourkioti, Eleni Paparouna, Christos P. Zampetidis, Sentiljana Gumeni, Ioannis P. Trougakos, Dafni-Eleftheria Pefani, Eric O’Neill, Sarantis Gagos, Aristides G. Eliopoulos, Wojciech Fendler, Dipanjan Chowdhury, Jiri Bartek, Vassi Published in: BMC Genomics, Issue 19/1, 2018, Page(s) 37-58, ISSN 1471-2164 Publisher: BioMed Central DOI: 10.1186/s12864-017-4375-1 Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability Author(s): Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard Sørensen, Jiri Bartek, Vassilis G. Gorgoulis Published in: Genome Biology, Issue 19/1, 2018, ISSN 1474-760X Publisher: Genome Biology DOI: 10.1186/s13059-018-1401-9 BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors Author(s): Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-11048-5 Integrating the DNA damage and protein stress responses during cancer development and treatment Author(s): Vassilis G Gorgoulis, Dafni-Eleftheria Pefani, Ioannis S Pateras, Ioannis P Trougakos Published in: The Journal of Pathology, Issue 246/1, 2018, Page(s) 12-40, ISSN 0022-3417 Publisher: John Wiley & Sons Inc. DOI: 10.1002/path.5097 Targeting BER enzymes in cancer therapy Author(s): Torkild Visnes, Maurice Grube, Bishoy Magdy Fekry Hanna, Carlos Benitez-Buelga, Armando Cázares-Körner, Thomas Helleday Published in: DNA Repair, Issue 71, 2018, Page(s) 118-126, ISSN 1568-7864 Publisher: Elsevier BV DOI: 10.1016/j.dnarep.2018.08.015 Senescence and senotherapeutics: a new field in cancer therapy Author(s): Vassilios Myrianthopoulos, Konstantinos Evangelou, Panagiotis V.S. Vasileiou, Tomer Cooks, Theodoros P. Vassilakopoulos, Gerassimos A. Pangalis, Myrsini Kouloukoussa, Christos Kittas, Alexandros G. Georgakilas, Vassilis G. Gorgoulis Published in: Pharmacology & Therapeutics, Issue 193, 2019, Page(s) 31-49, ISSN 0163-7258 Publisher: Pergamon Press DOI: 10.1016/j.pharmthera.2018.08.006 A Deep Learning Framework for Predicting Response to Therapy in Cancer Author(s): Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos, Tyler J. Moss, Sarina Piha-Paul, Hua Zhou, Eleni Kardala, Eleni Damianidou, Leonidas G. Alexopoulos, Iannis Aifantis, Paul A. Townsend, Mihalis I. Panayiotidis, Petros Sfikakis, Jiri Bartek, Rebecca C. Fitzgerald, Dimitris Thanos, Kenna R. Mills Shaw, Russell Petty, Aristotelis T Published in: Cell Reports, Issue 29/11, 2019, Page(s) 3367-3373.e4, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2019.11.017 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
