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Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network

Deliverables

Scientific publications

Task 5.6: Publish research findings (leads: all beneficiaries).

Direct interaction with the public

Task 5.3: Perform public outreach activities (all ESRs; lead: B7-UNIGE).

Presentations at scientific conferences

Task 5.5: Present research findings at international scientific conferences (leads: all beneficiaries).

Press releases

Task 5.4: Produce press releases (lead: B6-UOXF)

SYNTRAIN website

Task 5.1: Establishment of SYNTRAIN website (lead: B1-UCPH).

International scientific conference

Task 4.5: Organization of international scientific conference (leads: B3-UPAT and B5-DCS).

PhD theses

Task 4.6: Awarding of doctoral degrees (leads: all beneficiaries).

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Publications

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Author(s): Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06287-x

Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

Author(s): Jemina Lehto, Anna Huguet Ninou, Dimitrios Chioureas, Jos Jonkers, Nina M. S. Gustafsson
Published in: Cancers, 13/6, 2021, Page(s) 1442, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061442

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Author(s): Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz
Published in: Biomolecules, 10/11, 2020, Page(s) 1483, ISSN 2218-273X
Publisher: Biomolecules
DOI: 10.3390/biom10111483

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Author(s): Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero, Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita, Evert J Homan, Stella Kar
Published in: Nucleic Acids Research, 2020, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1048

Cellular senescence and failure of myelin repair in multiple sclerosis

Author(s): Paraskevi N. Koutsoudaki, Dimitrios Papadopoulos, Panagiotis-Georgios Passias, Pinelopi Koutsoudaki, Vassilis G. Gorgoulis
Published in: Mechanisms of Ageing and Development, 192, 2020, Page(s) 111366, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111366

DNA Damage and Cancer Immunotherapy: A STING in the Tale

Author(s): Timo Reisländer, Florian J. Groelly, Madalena Tarsounas
Published in: Molecular Cell, 80/1, 2020, Page(s) 21-28, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.07.026

Mitochondrial Homeostasis and Cellular Senescence

Author(s): Panagiotis Vasileiou, Konstantinos Evangelou, Konstantinos Vlasis, Georgios Fildisis, Mihalis Panayiotidis, Efstathios Chronopoulos, Panagiotis-Georgios Passias, Mirsini Kouloukoussa, Vassilis Gorgoulis, Sophia Havaki
Published in: Cells, 8/7, 2019, Page(s) 686, ISSN 2073-4409
Publisher: Cells
DOI: 10.3390/cells8070686

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Author(s): Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina v
Published in: Science, 362/6416, 2018, Page(s) 834-839, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar8048

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

Author(s): Reihaneh Zarrizi, Martin R. Higgs, Karolin Voßgröne, Maria Rossing, Birgitte Bertelsen, Muthiah Bose, Arne Nedergaard Kousholt, Heike Rösner, the COMPLEXO Network, Bent Ejlertsen, Grant S. Stewart, Finn Cilius Nielsen, Claus S. Sørensen
Published in: Journal of Clinical Investigation, bi weekly, 2020, Page(s) 4069-4080, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci127521

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

Author(s): Marianna Tampere, Aleksandra Pettke, Cristiano Salata, Olov Wallner, Tobias Koolmeister, Armando Cazares-Körner, Torkild Visnes, Maria Carmen Hesselman, Elena Kunold, Elisee Wiita, Christina Kalderén, Molly Lightowler, Ann-Sofie Jemth, Janne Lehtiö, Åsa Rosenquist, Ulrika Warpman-Berglund, Thomas Helleday, Ali Mirazimi, Rozbeh Jafari, Marjo-Riitta Puumalainen
Published in: Viruses, 12/12, 2020, Page(s) 1423, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12121423

Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance

Author(s): Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Published in: EMBO Molecular Medicine, 11/7, 2019, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809982

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

Author(s): Eirini-Stavroula Komseli, Ioannis S. Pateras, Thorbjørn Krejsgaard, Konrad Stawiski, Sophia V. Rizou, Alexander Polyzos, Fani-Marlen Roumelioti, Maria Chiourea, Ioanna Mourkioti, Eleni Paparouna, Christos P. Zampetidis, Sentiljana Gumeni, Ioannis P. Trougakos, Dafni-Eleftheria Pefani, Eric O’Neill, Sarantis Gagos, Aristides G. Eliopoulos, Wojciech Fendler, Dipanjan Chowdhury, Jiri Bartek, Vassi
Published in: BMC Genomics, 19/1, 2018, Page(s) 37-58, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-017-4375-1

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Author(s): Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard Sørensen, Jiri Bartek, Vassilis G. Gorgoulis
Published in: Genome Biology, 19/1, 2018, ISSN 1474-760X
Publisher: Genome Biology
DOI: 10.1186/s13059-018-1401-9

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Author(s): Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11048-5

Integrating the DNA damage and protein stress responses during cancer development and treatment

Author(s): Vassilis G Gorgoulis, Dafni-Eleftheria Pefani, Ioannis S Pateras, Ioannis P Trougakos
Published in: The Journal of Pathology, 246/1, 2018, Page(s) 12-40, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5097

Targeting BER enzymes in cancer therapy

Author(s): Torkild Visnes, Maurice Grube, Bishoy Magdy Fekry Hanna, Carlos Benitez-Buelga, Armando Cázares-Körner, Thomas Helleday
Published in: DNA Repair, 71, 2018, Page(s) 118-126, ISSN 1568-7864
Publisher: Elsevier BV
DOI: 10.1016/j.dnarep.2018.08.015

Senescence and senotherapeutics: a new field in cancer therapy

Author(s): Vassilios Myrianthopoulos, Konstantinos Evangelou, Panagiotis V.S. Vasileiou, Tomer Cooks, Theodoros P. Vassilakopoulos, Gerassimos A. Pangalis, Myrsini Kouloukoussa, Christos Kittas, Alexandros G. Georgakilas, Vassilis G. Gorgoulis
Published in: Pharmacology & Therapeutics, 193, 2019, Page(s) 31-49, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.08.006

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Author(s): Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos, Tyler J. Moss, Sarina Piha-Paul, Hua Zhou, Eleni Kardala, Eleni Damianidou, Leonidas G. Alexopoulos, Iannis Aifantis, Paul A. Townsend, Mihalis I. Panayiotidis, Petros Sfikakis, Jiri Bartek, Rebecca C. Fitzgerald, Dimitris Thanos, Kenna R. Mills Shaw, Russell Petty, Aristotelis T
Published in: Cell Reports, 29/11, 2019, Page(s) 3367-3373.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.11.017