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CORDIS

European Training Network for Cell-based Regenerative Medicine

Deliverables

Secondments completed

The report willgive an account of all completed secondments.Securing that all ESRs, as planned will be exposed to both an academic and an industrial setting either through recruitment or secondments. The SUPs will in close collaboration with the ESRs ensure that the planned secondments are appropriate to the ESR’ academic background, professional needs and career goals.

Report on exploitation and patenting activities

From the onset of Training4CRM we will focus on innovation and exploitable results. Rules for the use and dissemination of knowledge generated will be in place at the start of the project in the Consortium Agreement, detailing Intellectual Property Rights to prevent any potential conflicts. Transfer of knowledge to industry may include presentations/demos at industry fairs, articles in industrial organisations members’ bulletin, news articles etc., and of course more formal transfer through licensing or spinout. Whenever relevant beneficiaries and partners will take action towards patenting of exploitable results. IPR and exploitation of knowledge generated in Training4CRM will be the topics for the Exploitation of knowledge research school.

Necessary approvals and permits obtained and submitted to the Commission

For HUMAN EMBRYOS/FOETUSES (after GA) : 1. All the Human Pluripotent Stem Cells lines to be used must be registered in hPSCreg, copy of registration must be provided to REA 2. Human Neural Stem Cell lines lines to be used must be registered in hPSCreg ; copy of registration must be provided to REA 3. The project must be registered in hPSCreg and copy of this registration must be provided to REA For HUMAN CELLS / TISSUE (after GA, before the commencement of the research work) : 1. Copies of ethical/regulatory approvals must be submitted prior to the start of the relevant research activities. For ANIMALS (after GA, before the commencement of the research work): 1. Copies of ethical / regulatory approvals for the work to be carried out with animals must be submitted prior to the start of the relevant research activities. 2. Copies of personal licences and training certificates for the work to be carried out with animals (as indicated in the Part B Ethics Section) must be submitted prior to the start of the relevant research activities. If licences or training certificates expire during the course of the research, renewed documentation must be submitted in due time. For THIRD COUNTRIES (throughout the project): 1. The applicant must confirm that the ethical standards and guidelines of Horizon2020 will be rigorously applied, regardless of the country in which the research is carried out 2. The ethics advisor shall report about the H2020 compliance of third country partners to the project. For ENVIRONMENT PROTECTION AND SAFETY (after GA, before the commencement of the research work): 1. If relevant, copies of facilities authorisations must be provided (security classification of laboratory). 2. The applicant must ensure that appropriate health and safety procedures conforming to relevant local/national guidelines/legislation are followed for staff involved in this project. For OTHER ETHICS ISSUES (throughout the project): 1. The Ethics coordinator must report to the REA with the periodic reports and the final report, and whenever it is considered to be necessary by the Ethics coordinator. 2. A complete portfolio of copies of all ethical approvals that cover all aspects of the research by all of the partners of the Consortium throughout the lifetime of the project must be compiled and retained by the Ethics Advisory and must be available to the REA if requested and for Ethics Checks or Audits.

Final program for research school on Pre-clinical studies

Final program for research school on Pre-clinical studies incl. venue, lecturers, speakers etc

Final program for research school on Biotechnology

Competed program for research school on Biotechnology, incl. venue, speakers, letcurers etc

Final program for research school on Explotation

Final program for research school on Explotation, incl venue

Supervision team approval report

As the ESR are recruited the recruiting organisation must immediately create a supervision team (SUP) of 3 people, incl. a main supervisor from an academic beneficiary (from recruiting host or secondment host) and 2 co-supervisors, whereof at least one must be from an industrial beneficiary or partner. All SUPs must be approved by the SB and the Training Coordinator. For ESRs recruited M12 the report will be updated M13.

Final program for research school on Micro- and Nanoengineering

Programme for research school on Micro- and Nanoengineering, incl. venue, speakers, lecturers etc.

Establish plan for network-wide meetings

The SB will at the kick-off meeting decide on a plan for network-wide meetings throughout the project

Individual ESR public engagement plans / impact report

Dissemination to policy makers, end-users and the general public is the focus of the two public engagement workshops (research schools M12 and M18) where ESRs will make individual plans for appropriate activities. Activities should be relevant to the work of the ESR and be customised to the targeted audience. Activities may include taking part in DTU Science Programme for high school students, creating a 1 week, summer school for high school students, participation in Researchers’ Night, writing popular scientific articles in different magazines/newspapers, blogs, social media groups, IFLScience/Science Channel, YouTube etc. ESRs may be Marie Sklodowska-Curie Ambassadors. The Public Engagement Plans must be approved by the SB and the CEC. The plan must be revised M48.

Project logo and templates

The Coordinator will create a project logo and relevant templates (ppt, poster, mail banner). All beneficiary and partner logos, the EU emblem and all templates will be readily available at the Training4CRM intranet.

Report on scientific publications

This dissemination will mainly be scientific articles, oral lectures at conferences, guest lectures at host/secondment university, conference proceedings and posters, see also table 3.2.1. The CEC will monitor progress in scientific publications. Rules for publishing results from Training4CRM will be laid out in the CA.

Establish Supervisory Board

The Supervisory Board (SB) includes one key representative from each beneficiary. Members of the SB must function as supervisor forat least one ESR. The SB is part of the management of the project,and also has tasks related to WP5 on training and education.

Publish Training4CRM website

The Coordinator and the Communication and Exploitation Coordinator (UB) will create an appropriate structure for the Training4CRM website. The structure must take into account the different stakeholders. Every 3 months we will make a website visitor report to monitor number and behaviour of visits on Training4CRM website. These statistics will give us important pointers to continuously improve the website to fulfil its purpose of disseminating Training4CRM results to different audiences. DTU will host and maintain the website.

Network conference

Organization of the conference “Optoelectronics in NeuroSciences” at the end of the project. Target audience: Scientific community working in the closely related fields (neural engineering, biomaterials, etc. Impact assessment: Overall number of participants in the conference, both from academic and industrial sectors

Publications

Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases?

Author(s): Cristina Salado-Manzano, Unai Perpiña, Marco Straccia, Francisco J. Molina-Ruiz, Emanuele Cozzi, Anne E. Rosser, Josep M. Canals
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00250

Human cerebral organoids and neural 3D tissues in basic research, and their application to study neurological diseases

Author(s): Theresa S P Rothenbücher, Alberto Martínez-Serrano
Published in: Future Neurology, Issue 14/1, 2019, Page(s) FNL3, ISSN 1479-6708
Publisher: Future Medicine Ltd.
DOI: 10.2217/fnl-2018-0043

High-Value Tunable Pseudo-Resistors Design

Author(s): Emanuele Guglielmi, Fabio Toso, Francesco Zanetto, Giuseppe Sciortino, Alireza Mesri, Marco Sampietro, Giorgio Ferrari
Published in: IEEE Journal of Solid-State Circuits, Issue 55/8, 2020, Page(s) 2094-2105, ISSN 0018-9200
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jssc.2020.2973639

Wide Dynamic Range Multichannel Lock-In Amplifier for Contactless Optical Sensors With Sub-pS Resolution

Author(s): Francesco Zanetto, Emanuele Guglielmi, Fabio Toso, Rossella Gaudiano, Francesco Caruso, Marco Sampietro, Giorgio Ferrari
Published in: IEEE Solid-State Circuits Letters, Issue 3, 2020, Page(s) 246-249, ISSN 2573-9603
Publisher: IEEE
DOI: 10.1109/lssc.2020.3012920

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

Author(s): Shashank Vasudevan, Janko Kajtez, Ada‐Ioana Bunea, Ana Gonzalez‐Ramos, Tania Ramos‐Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez‐Serrano, Stephan S. Keller, Jenny Emnéus
Published in: Advanced Science, Issue 6/24, 2019, Page(s) 1902011, ISSN 2198-3844
Publisher: Advanced Science
DOI: 10.1002/advs.201902011

Systematic in vitro comparison of decellularization protocols for blood vessels

Author(s): Robin Simsa, Arvind Manikantan Padma, Philipp Heher, Mats Hellström, Andreas Teuschl, Lachmi Jenndahl, Niklas Bergh, Per Fogelstrand
Published in: PLOS ONE, Issue 13/12, 2018, Page(s) e0209269, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0209269

Extracellular Heme Proteins Influence Bovine Myosatellite Cell Proliferation and the Color of Cell-Based Meat

Author(s): Robin Simsa, John Yuen, Andrew Stout, Natalie Rubio, Per Fogelstrand, David L. Kaplan
Published in: Foods, Issue 8/10, 2019, Page(s) 521, ISSN 2304-8158
Publisher: FOODS (MDPI)
DOI: 10.3390/foods8100521

Effect of fluid dynamics on decellularization efficacy and mechanical properties of blood vessels

Author(s): Robin Simsa, Xavier Monforte Vila, Elias Salzer, Andreas Teuschl, Lachmi Jenndahl, Niklas Bergh, Per Fogelstrand
Published in: PLOS ONE, Issue 14/8, 2019, Page(s) e0220743, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0220743

WDM-Based Silicon Photonic Multi-Socket Interconnect Architecture With Automated Wavelength and Thermal Drift Compensation

Author(s): Francesco Zanetto, Vittorio Grimaldi, Miltiadis Moralis-Pegios, Stelios Pitris, Konstantinos Fotiadis, Theonitsa Alexoudi, Emanuele Guglielmi, Douglas Aguiar, Peter De Heyn, Yoojin Ban, Joris Van Campenhout, Nikos Pleros, Giorgio Ferrari, Marco Sampietro, Andrea Melloni
Published in: Journal of Lightwave Technology, Issue 38/21, 2020, Page(s) 6000-6006, ISSN 0733-8724
Publisher: Optical Society of America
DOI: 10.1109/jlt.2020.3008001

Machine learning for stem cell differentiation and proliferation classification on electrical impedance spectroscopy

Author(s): André B. Cunha, Jie Hou, Christin Schuelke
Published in: Journal of Electrical Bioimpedance, Issue 10/1, 2019, Page(s) 124-132, ISSN 1891-5469
Publisher: Sciendo
DOI: 10.2478/joeb-2019-0018

3D‐Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices

Author(s): Janko Kajtez, Sebastian Buchmann, Shashank Vasudevan, Marcella Birtele, Stefano Rocchetti, Christian Jonathan Pless, Arto Heiskanen, Roger A. Barker, Alberto Martínez‐Serrano, Malin Parmar, Johan Ulrik Lind, Jenny Emnéus
Published in: Advanced Science, Issue 7/16, 2020, Page(s) 2001150, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202001150

Pyrolytic Carbon Nanograss Enhances Neurogenesis and Dopaminergic Differentiation of Human Midbrain Neural Stem Cells

Author(s): Afia Asif, Silvia García‐López, Arto Heiskanen, Alberto Martínez‐Serrano, Stephan S. Keller, Marta P. Pereira, Jenny Emnéus
Published in: Advanced Healthcare Materials, Issue 9/20, 2020, Page(s) 2001108, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001108

A Laser Diode-Based Wireless Optogenetic Headstage

Author(s): Alireza Mesri; Marco Sampietro; Andre B. Cunha; Giorgio Ferrari; Orjan G. Martinsen
Published in: PRIME, Issue 1, 2018
Publisher: IEEE
DOI: 10.1109/prime.2018.8430348

Bioimpedance Measurements on Human Neural Stem Cells as a Benchmark for the Development of Smart Mobile Biomedical Applications

Author(s): André B. Cunha, Christin Schuelke, Arto Heiskanen, Afia Asif, Yasmin M. Hassan, Stephan S. Keller, Håvard Kalvøy, Alberto Martínez-Serrano, Jenny Emnéus, Ørjan G. Martinsen
Published in: 17th International Conference on Electrical Bioimpedance, Issue 1, 2020
Publisher: Springer
DOI: 10.1007/978-981-13-3498-6_6

Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis

Author(s): Shashank Vasudevan; Janko Kajtez; Arto Heiskanen; Jenny Emnéus; Stephan S. Keller
Published in: 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS), Issue annually, 2020
Publisher: IEEE
DOI: 10.1109/mems46641.2020.9056270

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