Cellular navigation along spatial gradients

Project Information

GRADIENTSENSING

Grant agreement ID: 724373

DOI

10.3030/724373

Project closed

EC signature date 13 March 2017

Start date 1 April 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 984 922,00

EU contribution

€ 1 984 922,00

Coordinated by

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Developmental Cell

Author(s): Gaertner, Florian; Reis-Rodrigues, Patricia; de Vries, Ingrid; Hons, Miroslav; Aguilera, Juan; Riedl, Michael; Leithner, Alexander F; Tasciyan, Saren; Kopf, Aglaja; Merrin, Jack; Zheden, Vanessa; Kaufmann, Walter; Hauschild, Robert; Sixt, Michael K
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.11.024

Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium

Author(s): Kari Vaahtomeri, Christine Moussion, Robert Hauschild, Michael Sixt
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.630002

Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration

Author(s): Alexander Leithner, Joerg Renkawitz, Ingrid De Vries, Robert Hauschild, Hans Häcker, Michael Sixt
Published in: European Journal of Immunology, Issue 48/6, 2018, Page(s) 1074-1077, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201747358

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

Author(s): Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V. Stein, Michael Sixt
Published in: Nature Immunology, Issue 19/6, 2018, Page(s) 606-616, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0109-z

Nuclear positioning facilitates amoeboid migration along the path of least resistance

Author(s): Jörg Renkawitz, Aglaja Kopf, Julian Stopp, Ingrid de Vries, Meghan K. Driscoll, Jack Merrin, Robert Hauschild, Erik S. Welf, Gaudenz Danuser, Reto Fiolka, Michael Sixt
Published in: Nature, Issue 568/7753, 2019, Page(s) 546-550, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1087-5

Cellular locomotion using environmental topography

Author(s): Anne Reversat, Florian Gaertner, Jack Merrin, Julian Stopp, Saren Tasciyan, Juan Aguilera, Ingrid de Vries, Robert Hauschild, Miroslav Hons, Matthieu Piel, Andrew Callan-Jones, Raphael Voituriez, Michael Sixt
Published in: Nature, Issue 582/7813, 2020, Page(s) 582-585, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2283-z

Microtubules control cellular shape and coherence in amoeboid migrating cells

Author(s): Aglaja Kopf, Jörg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry Tedford, Jack Merrin, Oliver Thorn-Seshold, Dirk Trauner, Hans Häcker, Klaus-Dieter Fischer, Eva Kiermaier, Michael Sixt
Published in: Journal of Cell Biology, Issue 219/6, 2020, Page(s) e201907154, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201907154

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

Author(s): Julia Damiano-Guercio, Laëtitia Kurzawa, Jan Mueller, Georgi Dimchev, Matthias Schaks, Maria Nemethova, Thomas Pokrant, Stefan Brühmann, Joern Linkner, Laurent Blanchoin, Michael Sixt, Klemens Rottner, Jan Faix
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55351

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse.

Author(s): Alexander Leithner; Alexander Leithner; Lukas M. Altenburger; Robert Hauschild; Frank P. Assen; Klemens Rottner; Theresia E. B. Stradal; Alba Diz-Muñoz; Jens V. Stein; Michael Sixt
Published in: The Journal of Cell Biology, Issue 1, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202006081