The role of complement in the induction of autoimmunity against post-translationally modified proteins

Project Information

AUTOCOMPLEMENT

Grant agreement ID: 724517

DOI 10.3030/724517

Project closed

EC signature date 6 June 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 802,50

EU contribution € 1 999 802,50

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

Publications

Peer reviewed articles (10)

Circulating C1q levels in health and disease, more than just a biomarker.

Author(s): Fleur S. van de Bovenkamp; Douwe J. Dijkstra; Cees van Kooten; Kyra A. Gelderman; Leendert A. Trouw
Published in: Molecular Immunology, Issue 1, 2021, Page(s) 206-2016, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2021.10.010

Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Author(s): Michelle D van den Beukel, Anna E C Stoelinga, Adriaan J van der Meer, Stef van der Meulen, Lu Zhang, Maarten E Tushuizen, Bart van Hoek, Leendert A Trouw
Published in: Front Med (Lausanne), Issue 2023 Jul 25:10:1195747, 2023, ISSN 2296-858X
Publisher: Frontiers in Medicine
DOI: 10.3389/fmed.2023.1195747

Single-cell reconstruction of follicular remodeling in the human adult ovary.

Author(s): Fan, X.; Bialecka, M.; Moustakas, I.; Lam, E.; Torrens-Juaneda, V.; Borggreven, N. V.; Trouw, L.; Louwe, L. A.; Pilgram, G. S. K.; Mei, H.; van der Westerlaken, L.; Chuva de Sousa Lopes, S. M.
Published in: Nature Communications, 10, Issue 1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11036-9

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Author(s): R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Published in: Clinical & Experimental Immunology, Issue 200/1, 2020, Page(s) 1-11, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

The role of complement activation in autoimmune liver disease

Author(s): Maaike Biewenga, Arantza Farina Sarasqueta, Maarten E. Tushuizen, Eveline S.M. de Jonge-Muller, Bart van Hoek, Leendert A. Trouw
Published in: Autoimmunity Reviews, 2020, Page(s) 102534, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2020.102534

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

Author(s): Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes
Published in: Annals of the Rheumatic Diseases, Issue 78/7, 2019, Page(s) 908-916, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214950

Complement activation and regulation in rheumatic disease

Author(s): Douwe J. Dijkstra, Jivan V. Joeloemsingh, Ingeborg M. Bajema, Leendert A. Trouw
Published in: Seminars in Immunology, Issue 45, 2019, Page(s) 101339, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2019.101339

Auto-antibodies to post-translationally modified proteins in osteoarthritis

Author(s): X Xie, M A M van Delft, F Shuweihdi, S R Kingsbury, L A Trouw, G M Doody, P G Conaghan, F Ponchel
Published in: Osteoarthritis and Cartilage, 2021, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2021.03.008

Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations

Author(s): Rory C Monahan, Michelle D van den Beukel, Nicole V Borggreven, Rolf Fronczek, Tom W J Huizinga, Margreet Kloppenburg, Gerda M Steup-Beekman, Leendert A Trouw
Published in: RMD Open, Issue 2022 Apr;8(1), 2022, ISSN 2056-5933
Publisher: BMJ
DOI: 10.1136/rmdopen-2021-002079

Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia

Author(s): Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.842451