The role of complement in the induction of autoimmunity against post-translationally modified proteins

Project Information

AUTOCOMPLEMENT

Grant agreement ID: 724517

DOI

10.3030/724517

Project closed

EC signature date 6 June 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 802,50

EU contribution

€ 1 999 802,50

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Author(s): Michelle D. van den Beukel, Anna E. C. Stoelinga, Adriaan J. van der Meer, Stef van der Meulen, Lu Zhang, Maarten E. Tushuizen, Bart van Hoek, Leendert A. Trouw
Published in: Frontiers in Medicine, Issue 10, 2023, ISSN 2296-858X
Publisher: Frontiers
DOI: 10.3389/fmed.2023.1297191

Circulating C1q levels in health and disease, more than just a biomarker.

Author(s): Fleur S. van de Bovenkamp; Douwe J. Dijkstra; Cees van Kooten; Kyra A. Gelderman; Leendert A. Trouw
Published in: Molecular Immunology, Issue 1, 2021, Page(s) 206-2016, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2021.10.010

Added value of multiple autoantibody testing for predicting progression to inflammatory arthritis in at-risk individuals

Author(s): Frederique Ponchel, Laurence Duquenne, Xuanxiao Xie, Diane Corscadden, Farag Shuweihdi, K Mankia, L A Trouw, Paul Emery
Published in: RMD Open, Issue 8, 2022, Page(s) e002512, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2022-002512

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Author(s): Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2024.1288597

Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Author(s): Michelle D van den Beukel, Anna E C Stoelinga, Adriaan J van der Meer, Stef van der Meulen, Lu Zhang, Maarten E Tushuizen, Bart van Hoek, Leendert A Trouw
Published in: Front Med (Lausanne), Issue 2023 Jul 25:10:1195747, 2023, ISSN 2296-858X
Publisher: Frontiers in Medicine
DOI: 10.3389/fmed.2023.1195747

Single-cell reconstruction of follicular remodeling in the human adult ovary.

Author(s): Fan, X.; Bialecka, M.; Moustakas, I.; Lam, E.; Torrens-Juaneda, V.; Borggreven, N. V.; Trouw, L.; Louwe, L. A.; Pilgram, G. S. K.; Mei, H.; van der Westerlaken, L.; Chuva de Sousa Lopes, S. M.
Published in: Nature Communications, 10, Issue 1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11036-9

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Author(s): R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Published in: Clinical & Experimental Immunology, Issue 200/1, 2020, Page(s) 1-11, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

The role of complement activation in autoimmune liver disease

Author(s): Maaike Biewenga, Arantza Farina Sarasqueta, Maarten E. Tushuizen, Eveline S.M. de Jonge-Muller, Bart van Hoek, Leendert A. Trouw
Published in: Autoimmunity Reviews, 2020, Page(s) 102534, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2020.102534

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

Author(s): Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes
Published in: Annals of the Rheumatic Diseases, Issue 78/7, 2019, Page(s) 908-916, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214950

Complement activation and regulation in rheumatic disease

Author(s): Douwe J. Dijkstra, Jivan V. Joeloemsingh, Ingeborg M. Bajema, Leendert A. Trouw
Published in: Seminars in Immunology, Issue 45, 2019, Page(s) 101339, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2019.101339

Auto-antibodies to post-translationally modified proteins in osteoarthritis

Author(s): X Xie, M A M van Delft, F Shuweihdi, S R Kingsbury, L A Trouw, G M Doody, P G Conaghan, F Ponchel
Published in: Osteoarthritis and Cartilage, 2021, ISSN 1063-4584
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2021.03.008

Differences in avidity of anti-post-translationally modified protein antibodies in mouse models and rheumatoid arthritis patients: not one-size-fits-all

Author(s): Stef van der Meulen, Lu Zhang, Jacqueline M F van Veenendaal, Diane van der Woude, Leendert A Trouw
Published in: RMD Open, Issue 10, 2024, Page(s) e004131, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2024-004131

Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations

Author(s): Rory C Monahan, Michelle D van den Beukel, Nicole V Borggreven, Rolf Fronczek, Tom W J Huizinga, Margreet Kloppenburg, Gerda M Steup-Beekman, Leendert A Trouw
Published in: RMD Open, Issue 2022 Apr;8(1), 2022, ISSN 2056-5933
Publisher: BMJ
DOI: 10.1136/rmdopen-2021-002079

Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia

Author(s): Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus
Published in: Frontiers in Immunology, Issue 1, 2022, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.842451

Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association

Author(s): Michelle D van den Beukel, Tineke J van Wesemael, Anna Titia W Hoogslag, Nicole V Borggreven, Tom WJ Huizinga, Annette HM van der Helm-van Mil, René EM Toes, Diane van der Woude, Leendert A Trouw
Published in: RMD Open, Issue 9, 2023, Page(s) e003480, ISSN 2056-5933
Publisher: BMJ publishing group
DOI: 10.1136/rmdopen-2023-003480