The role of complement in the induction of autoimmunity against post-translationally modified proteins

Informazioni relative al progetto

AUTOCOMPLEMENT

ID dell’accordo di sovvenzione: 724517

DOI

10.3030/724517

Progetto chiuso

Data della firma CE 6 Giugno 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 802,50

Contributo UE

€ 1 999 802,50

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (15)

Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Autori: Michelle D. van den Beukel, Anna E. C. Stoelinga, Adriaan J. van der Meer, Stef van der Meulen, Lu Zhang, Maarten E. Tushuizen, Bart van Hoek, Leendert A. Trouw
Pubblicato in: Frontiers in Medicine, Numero 10, 2023, ISSN 2296-858X
Editore: Frontiers
DOI: 10.3389/fmed.2023.1297191

Circulating C1q levels in health and disease, more than just a biomarker.

Autori: Fleur S. van de Bovenkamp; Douwe J. Dijkstra; Cees van Kooten; Kyra A. Gelderman; Leendert A. Trouw
Pubblicato in: Molecular Immunology, Numero 1, 2021, Pagina/e 206-2016, ISSN 0161-5890
Editore: Pergamon Press
DOI: 10.1016/j.molimm.2021.10.010

Added value of multiple autoantibody testing for predicting progression to inflammatory arthritis in at-risk individuals

Autori: Frederique Ponchel, Laurence Duquenne, Xuanxiao Xie, Diane Corscadden, Farag Shuweihdi, K Mankia, L A Trouw, Paul Emery
Pubblicato in: RMD Open, Numero 8, 2022, Pagina/e e002512, ISSN 2056-5933
Editore: BMJ publishing group
DOI: 10.1136/rmdopen-2022-002512

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Autori: Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2024.1288597

Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Autori: Michelle D van den Beukel, Anna E C Stoelinga, Adriaan J van der Meer, Stef van der Meulen, Lu Zhang, Maarten E Tushuizen, Bart van Hoek, Leendert A Trouw
Pubblicato in: Front Med (Lausanne), Numero 2023 Jul 25:10:1195747, 2023, ISSN 2296-858X
Editore: Frontiers in Medicine
DOI: 10.3389/fmed.2023.1195747

Single-cell reconstruction of follicular remodeling in the human adult ovary.

Autori: Fan, X.; Bialecka, M.; Moustakas, I.; Lam, E.; Torrens-Juaneda, V.; Borggreven, N. V.; Trouw, L.; Louwe, L. A.; Pilgram, G. S. K.; Mei, H.; van der Westerlaken, L.; Chuva de Sousa Lopes, S. M.
Pubblicato in: Nature Communications, 10, Numero 1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11036-9

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Autori: R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Pubblicato in: Clinical & Experimental Immunology, Numero 200/1, 2020, Pagina/e 1-11, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

The role of complement activation in autoimmune liver disease

Autori: Maaike Biewenga, Arantza Farina Sarasqueta, Maarten E. Tushuizen, Eveline S.M. de Jonge-Muller, Bart van Hoek, Leendert A. Trouw
Pubblicato in: Autoimmunity Reviews, 2020, Pagina/e 102534, ISSN 1568-9972
Editore: Elsevier BV
DOI: 10.1016/j.autrev.2020.102534

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

Autori: Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes
Pubblicato in: Annals of the Rheumatic Diseases, Numero 78/7, 2019, Pagina/e 908-916, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214950

Complement activation and regulation in rheumatic disease

Autori: Douwe J. Dijkstra, Jivan V. Joeloemsingh, Ingeborg M. Bajema, Leendert A. Trouw
Pubblicato in: Seminars in Immunology, Numero 45, 2019, Pagina/e 101339, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2019.101339

Auto-antibodies to post-translationally modified proteins in osteoarthritis

Autori: X Xie, M A M van Delft, F Shuweihdi, S R Kingsbury, L A Trouw, G M Doody, P G Conaghan, F Ponchel
Pubblicato in: Osteoarthritis and Cartilage, 2021, ISSN 1063-4584
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2021.03.008

Differences in avidity of anti-post-translationally modified protein antibodies in mouse models and rheumatoid arthritis patients: not one-size-fits-all

Autori: Stef van der Meulen, Lu Zhang, Jacqueline M F van Veenendaal, Diane van der Woude, Leendert A Trouw
Pubblicato in: RMD Open, Numero 10, 2024, Pagina/e e004131, ISSN 2056-5933
Editore: BMJ publishing group
DOI: 10.1136/rmdopen-2024-004131

Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations

Autori: Rory C Monahan, Michelle D van den Beukel, Nicole V Borggreven, Rolf Fronczek, Tom W J Huizinga, Margreet Kloppenburg, Gerda M Steup-Beekman, Leendert A Trouw
Pubblicato in: RMD Open, Numero 2022 Apr;8(1), 2022, ISSN 2056-5933
Editore: BMJ
DOI: 10.1136/rmdopen-2021-002079

Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia

Autori: Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus
Pubblicato in: Frontiers in Immunology, Numero 1, 2022, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.842451

Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association

Autori: Michelle D van den Beukel, Tineke J van Wesemael, Anna Titia W Hoogslag, Nicole V Borggreven, Tom WJ Huizinga, Annette HM van der Helm-van Mil, René EM Toes, Diane van der Woude, Leendert A Trouw
Pubblicato in: RMD Open, Numero 9, 2023, Pagina/e e003480, ISSN 2056-5933
Editore: BMJ publishing group
DOI: 10.1136/rmdopen-2023-003480