Objective Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice. This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms. A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes. This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans. Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease. Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesphysical sciencesopticsmicroscopysuper resolution microscopynatural sciencesbiological scienceshistology Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2016-COG - ERC Consolidator Grant Call for proposal ERC-2016-COG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Coordinator LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. Net EU contribution € 1 997 973,00 Address Albert einstein strasse 9 07745 Jena Germany See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. Germany Net EU contribution € 1 997 973,00 Address Albert einstein strasse 9 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY OF DUNDEE Participation ended United Kingdom Net EU contribution € 0,00 Address Nethergate DD1 4HN Dundee See on map Region Scotland Eastern Scotland Angus and Dundee City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
