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Holographic super-resolution micro-endoscopy for in-vivo applications

Objective

Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice.
This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms.
A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes.
This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans.
Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease.
Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ.

Field of science

  • /natural sciences/biological sciences/neurobiology
  • /medical and health sciences/basic medicine/neurology/alzheimer
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

ERC-2016-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Address
Albert Einstein Strasse 9
07745 Jena
Germany
Activity type
Research Organisations
EU contribution
€ 1 843 454,99

Beneficiaries (2)

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany
EU contribution
€ 1 843 454,99
Address
Albert Einstein Strasse 9
07745 Jena
Activity type
Research Organisations
UNIVERSITY OF DUNDEE

Participation ended

United Kingdom
EU contribution
€ 154 518,01
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments