The functional interaction of EGFR and beta-catenin signalling in colorectal cancer: Genetics, mechanisms, and therapeutic potential.

Publications

PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity

Auteurs: Montemurro M, Grassi E, Pizzino CG, Bertotti A, Ficarra E, Urgese G.
Publié dans: BMC Bioinformatics, 2021, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-021-04277-3

EGAsubmitter: A software to automate submission of nucleic acid sequencing data to the European Genome-phenome Archive

Auteurs: Viviani M, Montemurro M, Trusolino L, Bertotti A, Urgese G, Grassi E.
Publié dans: Frontiers in Bioinformatics, 2023, ISSN 2673-7647
Éditeur: Frontiers
DOI: 10.3389/fbinf.2023.1143014

Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity

Auteurs: Silvia Cascianelli; Chiara Barbera; Alexandra Ambra Ulla; Elena Grassi; Barbara Lupo; Diego Pasini; Andrea Bertotti; Livio Trusolino; Enzo Medico; Claudio Isella; Marco Masseroli
Publié dans: Genome Medicine, Numéro 2, 2023, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-023-01176-5

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Auteurs: Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline
Publié dans: Nature Genetics, Numéro 53/1, 2021, Page(s) 86-99, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-020-00750-6

Effective drug combinations in breast, colon and pancreatic cancer cells

Auteurs: Patricia Jaaks; Elizabeth A. Coker; Daniel J. Vis; Olivia Edwards; Emma F. Carpenter; Simonetta M. Leto; Lisa Dwane; Francesco Sassi; Howard Lightfoot; Syd Barthorpe; Dieudonne van der Meer; Wanjuan Yang; Alexandra Beck; Tatiana Mironenko; Caitlin Hall; James Hall; Iman Mali; Laura Richardson; Charlotte Tolley; James Morris; Frances Thomas; Ermira Lleshi; Nanne Aben; Cyril H. Benes; Andrea Bertott
Publié dans: NATURE, Numéro 7, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-04437-2

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Auteurs: Bas Ponsioen; Jasmin B. Post; Julian R. Buissant des Amorie; Dimitrios Laskaris; Ravian L. van Ineveld; Simone Kersten; Andrea Bertotti; Francesco Sassi; François Sipieter; François Sipieter; Benjamin Cappe; Sander Mertens; Ingrid Verlaan-Klink; Sylvia F. Boj; Rob G. J. Vries; Holger Rehmann; Peter Vandenabeele; Franck B. Riquet; Franck B. Riquet; Livio Trusolino; Johannes L. Bos; Hugo J. Snippe
Publié dans: Nature Cell BIology, Numéro 8, 2021, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells

Auteurs: Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M.
Publié dans: Nature Genetics, 2022, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-022-01105-z

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system

Auteurs: Simone Pernice; Roberta Sirovich; Elena Grassi; Marco Viviani; Martina Ferri; Francesco Sassi; Luca Alessandrı; Dora Tortarolo; Raffaele A. Calogero; Livio Trusolino; Andrea Bertotti; Marco Beccuti; Martina Olivero; Francesca Cordero
Publié dans: Bioinformatics, Numéro 7, 2023, ISSN 1367-4811
Éditeur: Oxford University Press
DOI: 10.1101/2022.08.08.503120

One tool to find them all: a case of data integration and querying in a distributed LIMS platform

Auteurs: Alberto Grand, Emanuele Geda, Andrea Mignone, Andrea Bertotti, Alessandro Fiori
Publié dans: Database, Numéro 2019, 2019, ISSN 1758-0463
Éditeur: Oxford University Press
DOI: 10.1093/database/baz004

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Auteurs: Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Gonçalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari, Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne van der Meer, David Dow, Carolyn Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan A. Stronach, Julio Saez-Rodriguez, Kosu
Publié dans: Nature, Numéro 568/7753, 2019, Page(s) 511-516, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-019-1103-9

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Auteurs: Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Publié dans: Clinical Cancer Research, Numéro 25/20, 2019, Page(s) 6243-6259, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3440

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Auteurs: Catalano Irene, Grassi Elena, Bertotti Andrea, Trusolino Livio
Publié dans: TRENDS IN CANCER, 2019, ISSN 2405-8033
Éditeur: Cell press
DOI: 10.1016/j.trecan.2019.10.006

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Auteurs: Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro Magrì, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini, Ludovic Barault, Luca Novara, Claudio Isella, Enzo Medico, Andrea Bertotti, Livio Trusolino, Giovanni Germano, Federica Di Nicolantonio, Alberto Bardelli
Publié dans: Genome Medicine, Numéro 11/1, 2019, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-019-0654-6

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

Auteurs: Annalisa Lorenzato, Alessandro Magrì, Vittoria Matafora, Valentina Audrito, Pamela Arcella, Luca Lazzari, Monica Montone, Simona Lamba, Silvia Deaglio, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Angela Bachi, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Publié dans: Cancers, Numéro 12/3, 2020, Page(s) 685, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030685

EGFR blockade reverts resistance to KRAS G12C inhibition in colorectal cancer

Auteurs: Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, B
Publié dans: Cancer Discovery, 2020, Page(s) CD-20-0187, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Auteurs: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Publié dans: Science Translational Medicine, Numéro 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Auteurs: Leto SM, Ferri M, Sassi F, Zanella ER, Cottino F, Vurchio V, Catalano I, Ferrero A, Zingaretti CC, Marchiò C, Grassi E, Trusolino L, Bertotti A.
Publié dans: Clinical Cancer Reseearch, 2023, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-2550

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