Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus

Project Information

ThymusTolerance

Grant agreement ID: 724821

DOI

10.3030/724821

Project closed

EC signature date 8 May 2017

Start date 1 September 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 220 000,00

EU contribution

€ 2 220 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.

Author(s): Yael Goldfarb; Tal Givony; Noam Kadouri; Jan Dobeš; Cristina Peligero-Cruz; Itay Zalayat; Golda M. Damari; Bareket Dassa; Shifra Ben-Dor; Yael Gruper; Bergithe E. Oftedal; Eirik Bratland; Martina M. Erichsen; Amund Holte Berger; Ayelet Avin; Shir Nevo; Uku Haljasorg; Uku Haljasorg; Yael Kuperman; Adi Ulman; Rebecca Haffner-Krausz; Ziv Porat; Ulus Atasoy; Dena Leshkowitz; Eystein S. Husebye; Eyste
Published in: Journal of Experimental Medicine, Issue Vol. 218 No. 11, 2021, Page(s) 1-24, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201076

Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans.

Author(s): Dobeš J, Ben-Nun O, Binyamin A, Stoler-Barak L, Oftedal BE, Goldfarb Y, Kadouri N, Gruper Y, Givony T, Zalayat I, Kováčová K, Böhmová H, Valter E, Shulman Z, Filipp D, Husebye ES, Abramson J.
Published in: Nature Immunology, 2022, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-022-01247-6

IL18 signaling promotes homing of mature Tregs into the thymus

Author(s): Cristina Peligero-Cruz; Tal Givony; Arnau Sebé-Pedrós; Jan Dobeš; Noam Kadouri; Shir Nevo; Francesco Roncato; Ronen Alon; Yael Goldfarb; Jakub Abramson
Published in: eLife, Issue 1, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58213

Tuft cells: From the mucosa to the thymus

Author(s): Shir Nevo, Noam Kadouri, Jakub Abramson
Published in: Immunology Letters, Issue 210, 2019, Page(s) 1-9, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2019.02.003

Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations

Author(s): Ayelet Avin, Maayan Levy, Ziv Porat, Jakub Abramson
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01808-6

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Author(s): Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S. Zimmermann, Jakub Abramson, Ido Amit
Published in: Nature, Issue 559/7715, 2018, Page(s) 622-626, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0346-1

Thymic Epithelial Cells

Author(s): Jakub Abramson, Graham Anderson
Published in: Annual Review of Immunology, Issue 35/1, 2017, Page(s) 85-118, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-051116-052320

Thymic epithelial cell heterogeneity: TEC by TEC

Author(s): Noam Kadouri, Shir Nevo, Yael Goldfarb, Jakub Abramson
Published in: Nature Reviews Immunology, Issue 20/4, 2020, Page(s) 239-253, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-019-0238-0

Transcriptional regulation of the thymus master regulator Foxn1

Author(s): Kadouri N, Givony T, Nevo S, Hey J, Ben Dor S, Damari G, Dassa B, Dobes J, Weichenhan D, Bähr M, Paulsen M, Haffner-Krausz R, Mall MA, Plass C, Goldfarb Y, Abramson J.
Published in: Science Immunology, 2022, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.abn8144