Stability and dynamics at different spatial scales: From physiology to Alzheimer's degeneration

Project Information

MacroStability

Grant agreement ID: 724866

DOI 10.3030/724866

Project closed

EC signature date 2 March 2017

Start date 1 October 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

Publications

Peer reviewed articles (14)

Longitudinal in vivo imaging of perineuronal nets

Author(s): Amit Benbenishty, Shany Peled-Hajaj, Venkat Raghavan Krishnaswamy, Hagai Har-Gil, Sapir Havusha-Laufer, Antonella Ruggiero, Inna Slutsky, Pablo Blinder, Irit Sagi
Published in: Neurophotonics, Issue 015008 (March 2023)., 2023, ISSN 2329-4248
Publisher: spie
DOI: 10.1117/1.nph.10.1.015008

M-Current Inhibition in Hippocampal Excitatory Neurons Triggers Intrinsic and Synaptic Homeostatic Responses at Different Temporal Scales

Author(s): Lezmy Jonathan, Gelman Hana, Katsenelson Maxim, Styr Boaz, Tikochinsky, Eliav Lipinsky, Maya Peretz, Asher, Slutsky Inna, Attali Bernard
Published in: The Journal of Neuroscience, Issue 40(19), 2020, Page(s) 3694–3706, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1914-19.2020

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Author(s): Maxim Katsenelson; Ilana Shapira; Eman Abbas; Kristina Jevdokimenko; Boaz Styr; Antonella Ruggiero; Saba Aïd; Eugenio F. Fornasiero; Martin Holzenberger; Silvio O. Rizzoli; Inna Slutsky
Published in: Proc Natl Acad Sci U S A ., Issue 1, 2022, Page(s) Aug 16;119(33):e2121040119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2121040119

Intrinsic fluorescence of nucleobase crystals

Author(s): Ruth Aizen, Zohar A. Arnon, Or Berger, Antonella Ruggiero, Dor Zaguri, Noam Brown, Evgeny Shirshin, Inna Slutsky, Ehud Gazit
Published in: Nanoscale Advances, 2022, Page(s) eCollection 2023 Jan 18., ISSN 2516-0230
Publisher: Royal Society of Chemistry and the National Center for Nanoscience and Technology
DOI: 10.1039/d2na00551d

Hippocampal sub-networks exhibit distinct spatial representation deficits in Alzheimer’s disease model mice

Author(s): Rechnitz Ohad, Slutsky Inna, Morris Genela, Derdikman Dori
Published in: Current Biology, Issue 31(15), 2021, Page(s) 3292-3302.e6, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.05.039

Mitochondria: new players in homeostatic regulation of firing rate set points

Author(s): Ruggiero, Antonella, Katsenelson, Maxim, Slutsky, Inna
Published in: Trends in Neurosciences, Issue 2021/08/01/, 2021, Page(s) 605-618, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2021.03.002

Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease

Author(s): Boaz Styr, Inna Slutsky
Published in: Nature Neuroscience, Issue 21/4, 2018, Page(s) 463-473, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0080-x

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

Author(s): Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky
Published in: Neuron, Issue 102(5), 2019, Page(s) 1009–1024.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.03.045

Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Author(s): Heather C. Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N. Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M. Ranaivoson, Davide Comoletti, Jeffrey N. Savas, Han Remaut, Detlef Balschun, Keimpe D. Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit
Published in: Science, Issue 363/6423, 2019, Page(s) eaao4827, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao4827

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

Author(s): Samuel Frere, Inna Slutsky
Published in: Neuron, Issue 97/1, 2018, Page(s) 32-58, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.11.028

Measuring synaptic transmission and plasticity with fEPSP recordings in behaving mice

Author(s): Leore R. Heim, Shiri Shoob, Lior de Marcas, Daniel Zarhin, Inna Slutsky
Published in: STAR Protocols, Issue 2022/03/18/, 2022, Page(s) Pages 1009-1024.e8, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.101115

Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models

Author(s): Zarhin D, Atsmon R, Ruggiero A, Baeloha H, Shoob S, Scharf O, Heim L.R., Buchbinder N, Shinikamin O, Shapira I, Styr B, Braun G, Harel M, Sheinin A, Geva N, Sela Y, Saito T, Saido T, Geiger T, Nir Y, Ziv Y, Slutsky I.
Published in: Cell Reports, Issue 38(3), 2022, Page(s) 110268, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110268

Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer's disease mouse model

Author(s): Shiri Shoob, Nadav Buchbinder, Ortal Shinikamin, Or Gold, Halit Baeloha, Tomer Langberg, Daniel Zarhin, Ilana Shapira, Gabriella Braun, Naomi Habib & Inna Slutsky
Published in: Nature Communications, Issue 7002 (2023), 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42721-5

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease

Author(s): Sara Calafate, Gökhan Özturan, Nicola Thrupp, Jeroen Vanderlinden, Luísa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverría, Marcelo Dias, Wei-Ting Chen, Mark Fiers, Ashley Lu, Ine Vlaeminck, Eline Creemers, Katleen Craessaerts, Joris Vandenbempt, Luuk van Boekholdt, Suresh Poovathingal, Kristofer Davie, Dietmar Rudolf Thal, Keim
Published in: Nature Neuroscience, Issue 26 (2023), 2023, Page(s) 1021–1031, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01325-4

Non-peer reviewed articles (1)

The Sound of Silence: Hidden Responses of Neural Circuits to Alzheimer-Linked Mutations

Author(s): Refaela Atsmon, Inna Slutsky
Published in: Neuron, Issue 107/6, 2020, Page(s) 990-991, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.08.016