Getting to the root of ageing: somatic decay as a cost of germline maintenance

Project Information

GermlineAgeingSoma

Grant agreement ID: 724909

DOI

10.3030/724909

Project closed

EC signature date 17 August 2017

Start date 1 September 2017

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITY OF EAST ANGLIA
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Fitness benefits of dietary restriction

Author(s): Zahida Sultanova; Edward Ivimey-Cook; Tracey Chapman; Alexei A. Maklakov
Published in: Proceedings of the Royal Society B: Biological Sciences, Issue 1, 2021, ISSN 0370-1662
Publisher: Royal Society
DOI: 10.1098/rspb.2021.1787

Intergenerational Transfer of Ageing: Parental Age and Offspring Lifespan.

Author(s): Monaghan, Pat; Maklakov, Alexei A.; Metcalfe, Neil B.
Published in: 0169-5347, Issue 6, 2020, ISSN 1872-8383
Publisher: n/a
DOI: 10.1016/j.tree.2020.07.005

Inbreeding reduces fitness of seed beetles under thermal stress

Author(s): Edward Ivimey-Cook; Sophie Bricout; Victoria Candela; Alexei A. Maklakov; Elena C. Berg
Published in: Journal of Evolutionary Biology, Issue 2, 2021, ISSN 1420-9101
Publisher: n/a
DOI: 10.1101/2021.05.05.442709

Ageing as “early-life inertia”: Disentangling life-history trade-offs along a lifetime of an individual

Author(s): Hanne Carlsson,Edward Ivimey-Cook,Elizabeth M. L. Duxbury,Nathan Edden,Kris Sales,Alexei A. Maklakov
Published in: Evolution Letters, Issue 5, 2021, Page(s) 551-564, ISSN 2056-3744
Publisher: ESEB
DOI: 10.1002/evl3.254

Multigenerational downregulation of insulin/IGF‐1 signaling in adulthood improves lineage survival, reproduction, and fitness in <i>Caenorhabditis elegans</i> supporting the developmental theory of ageing

Author(s): Elizabeth M. L. Duxbury; Hanne Carlsson; Kris Sales; Zahida Sultanova; Simone Immler; Tracey Chapman; Alexei A. Maklakov
Published in: Evolution, Issue 4, 2022, ISSN 1558-5646
Publisher: n/a
DOI: 10.1111/evo.14640

Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring

Author(s): Martin I. Lind, Sanjana Ravindran, Zuzana Sekajova, Hanne Carlsson, Andrea Hinas, Alexei A. Maklakov
Published in: Evolution Letters, Issue 3/2, 2019, Page(s) 207-216, ISSN 2056-3744
Publisher: Wiley
DOI: 10.1002/evl3.108

Evolution Under Dietary Restriction Decouples Survival From Fecundity in Drosophila melanogaster Females

Author(s): Felix Zajitschek, Grigorios Georgolopoulos, Anna Vourlou, Maja Ericsson, Susanne R K Zajitschek, Urban Friberg, Alexei A Maklakov
Published in: The Journals of Gerontology: Series A, 2018, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/gly070

Sex differences in adult mortality rate mediated by early-life environmental conditions

Author(s): Robert M. Griffin, Adam D. Hayward, Elisabeth Bolund, Alexei A. Maklakov, Virpi Lummaa
Published in: Ecology Letters, Issue 21/2, 2018, Page(s) 235-242, ISSN 1461-023X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ele.12888

Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes

Author(s): Brian S Mautz, Martin I Lind, Alexei A Maklakov
Published in: The Journals of Gerontology: Series A, Issue 75/5, 2019, Page(s) 843-848, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/glz276

Environmental variation mediates the evolution of anticipatory parental effects

Author(s): Martin I. Lind, Martyna K. Zwoinska, Johan Andersson, Hanne Carlsson, Therese Krieg, Tuuli Larva, Alexei A. Maklakov
Published in: Evolution Letters, Issue online first, 2020, Page(s) online, ISSN 2056-3744
Publisher: Wiley
DOI: 10.1002/evl3.177

Evolution of ageing as a tangle of trade-offs: energy versus function

Author(s): Alexei A. Maklakov, Tracey Chapman
Published in: Proceedings of the Royal Society B: Biological Sciences, Issue 286/1911, 2019, Page(s) 20191604, ISSN 0962-8452
Publisher: Royal Society of London
DOI: 10.1098/rspb.2019.1604

Silver‐spoon upbringing improves early‐life fitness but promotes reproductive ageing in a wild bird

Author(s): Foteini Spagopoulou, Céline Teplitsky, Stéphane Chantepie, Martin I. Lind, Lars Gustafsson, Alexei A. Maklakov
Published in: Ecology Letters, Issue 23/6, 2020, Page(s) 994-1002, ISSN 1461-023X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ele.13501

Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

Author(s): Edward R. Ivimey-Cook, Kris Sales, Hanne Carlsson, Simone Immler, Tracey Chapman and Alexei A. Maklakov
Published in: Proceedings of the Royal Society B: Biological Sciences, 2021, ISSN 0962-8452
Publisher: Royal Society of London
DOI: 10.1098/rspb.2021.0701

Beneficial cumulative effects of old parental age on offspring fitness

Author(s): Laura M. Travers, Hanne Carlsson, Martin I. Lind and Alexei A. Maklakov
Published in: Proceedings of the Royal Society B: Biological Sciences, 2021, ISSN 0962-8452
Publisher: Royal Society of London
DOI: 10.1098/rspb.2021.1843

Other (4)

Variable environments select for short lifespan

Author(s): Martin I. Lind, Irja I. Ratikainen, Johan Andersson, Hanne Carlsson, Therese Krieg, Tuuli Larva, Alexei A. Maklakov
Published in: bioRxiv pre-print server, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.01.29.924373

Cost-free lifespan extension via optimisation of gene expression in adulthood supports the developmental theory of ageing

Author(s): Martin I. Lind, Hanne Carlsson, Edward Ivimey-Cook, Alexei A. Maklakov
Published in: bioRxiv pre-print server, 2020
Publisher: bioRxiv
DOI: 10.1101/739490

Evolutionary causes of lifespan extension by dietary restriction: linking theory and mechanisms

Author(s): Laura M. Travers, Hanne Carlsson, Elizabeth M. L. Duxbury, Alexei A. Maklakov
Published in: bioRxiv pre-print server, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.01.14.904599

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

Author(s): Edward R Ivimey-Cook, David S. Murray, Jean-Charles de Coriolis, Nathan Edden, Simone Immler, Alexei A. Maklakov
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbour
DOI: 10.1101/2022.07.18.500454