Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health

Project Information

MITOSENSING

Grant agreement ID: 725004

DOI

10.3030/725004

Project closed

EC signature date 22 February 2017

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 573,00

EU contribution

€ 1 999 573,00

Coordinated by

FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner

Author(s): Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Published in: Redox Biology, Issue 41, 2021, Page(s) 101945, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.101945

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Author(s): Alicia G. Gómez-Valadés, Macarena Pozo, Luis Varela, Mehdi Boutagouga Boudjadja, Sara Ramírez, Iñigo Chivite, Elena Eyre, Roberta Haddad-Tóvolli, Arnaud Obri, Maria Milà-Guasch, Jordi Altirriba, Marc Schneeberger, Mónica Imbernón, Angela R. Garcia-Rendueles, Pau Gama-Perez, Jonathan Rojo-Ruiz, Bence Rácz, Maria Teresa Alonso, Ramon Gomis, Antonio Zorzano, Giuseppe D’Agostino, Clara V. A
Published in: Cell Metabolism, Issue 33/9, 2021, Page(s) 1820-1835.e9, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.07.008

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

Author(s): Carmelo Quarta, Marc Claret, Lori M. Zeltser, Kevin W. Williams, Giles S. H. Yeo, Matthias H. Tschöp, Sabrina Diano, Jens C. Brüning, Daniela Cota
Published in: Nature Metabolism, Issue 3/3, 2021, Page(s) 299-308, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-021-00345-3

Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection

Author(s): Macarena Pozo, Marc Claret
Published in: Trends in Endocrinology & Metabolism, Issue 29/8, 2018, Page(s) 581-594, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2018.05.001

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Author(s): Roberta Haddad-Tóvolli, Jordi Altirriba, Arnaud Obri, Elena Eyre Sánchez, Iñigo Chivite, Maria Milà-Guasch, Sara Ramírez, Alicia G. Gómez-Valadés, Macarena Pozo, Jasmine Burguet, Licio A. Velloso, Marc Claret
Published in: Molecular Metabolism, Issue 36, 2020, Page(s) 100963, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.006

Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

Author(s): Stéphanie Herkenne, Olivier Ek, Margherita Zamberlan, Anna Pellattiero, Maya Chergova, Iñigo Chivite, Eliška Novotná, Giovanni Rigoni, Tiago Branco Fonseca, Dijana Samardzic, Andrielly Agnellini, Camilla Bean, Giulietta Di Benedetto, Natascia Tiso, Francesco Argenton, Antonella Viola, Maria Eugenia Soriano, Marta Giacomello, Elena Ziviani, Gabriele Sales, Marc Claret, Mariona Graupera, Luca Sc
Published in: Cell Metabolism, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.04.007

Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits.

Author(s): Haddad-Tóvolli R, Ramírez S, Muñoz-Moreno E, Milà-Guasch M, Miquel-Rio L, Pozo M, Chivite I, Altirriba J, Obri A, Gómez-Valadés AG, Toledo M, Eyre E, Bortolozzi A, Valjent E, Soria G, Claret M.
Published in: Nature Metabolism, 2022, ISSN 2522-5812
Publisher: Nature Portfolio
DOI: 10.1038/s42255-022-00557-1

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders.

Author(s): Ramírez S, Haddad-Tóvolli R, Radosevic M, Toledo M, Pané A, Alcolea D, Ribas V, Milà-Guasch M, Pozo M, Obri A, Eyre E, Gómez-Valadés AG, Chivite I, Van Eeckhout T, Zalachoras I, Altirriba J, Bauder C, Imbernón M, Garrabou G, Garcia-Ruiz C, Nogueiras R, Soto D, Gasull X, Sandi C, Brüning JC, Fortea J, Jiménez A, Fernández-Checa JC, Claret M.
Published in: Cell Metabolism, 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.12.023

Other (1)

Cooperative tanycytes fuel the neuronal tank

Author(s): Haddad-Tóvolli R, Claret M.
Published in: Journal of Clinical Investigation, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci153279