The Missing Link of Episodic Memory Decline in Aging: The Role of Inefficient Systems Consolidation

Project Information

AgeConsolidate

Grant agreement ID: 725025

DOI 10.3030/725025

Project closed

EC signature date 7 April 2017

Start date 1 May 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 481,75

EU contribution € 1 999 481,75

Coordinated by

UNIVERSITETET I OSLO
Norway

Publications

Peer reviewed articles (35)

Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

Author(s): Anders M. Fjell, Øystein Sørensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baaré, David Bartrés-Faz, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kühn, Kathrine Skak Madsen, Lars Nyberg, Cristina Solé-Padullés, Didac Vidal-Piñeiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Published in: Journal of Neuroscience, Issue 12 July 2023, 43 (28), 2023, Page(s) 5241-5250, ISSN 1529-2401
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2330-22.2023

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

Author(s): James M Roe; Didac Vidal-Pineiro; Inge K Amlien; Mengyu Pan; Markus H Sneve; Michel Thiebaut de Schotten; Patrick Friedrich; Zhiqiang Sha; Clyde Francks; Espen M Eilertsen; Yunpeng Wang; Kristine B Walhovd; Anders M Fjell; René Westerhausen
Published in: eLife, Issue 8, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.84685

Age-Related Differences in Functional Asymmetry During Memory Retrieval Revisited: No Evidence for Contralateral Overactivation or Compensation

Author(s): James M Roe, Didac Vidal-Piñeiro, Markus H Sneve, Kristiina Kompus, Douglas N Greve, Kristine B Walhovd, Anders M Fjell, René Westerhausen
Published in: Cerebral Cortex, Issue 30/3, 2019, Page(s) 1129-1147, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz153

The functional foundations of episodic memory remain stable throughout the lifespan

Author(s): Håkon Grydeland; James Michael Roe; Anders M. Fjell; Anders M. Fjell; Didac Vidal-Piñeiro; Øystein Sørensen; Lars H Nyberg; Inge K. Amlien; Markus Handal Sneve; Kristine B. Walhovd; Kristine B. Walhovd; Athanasia M. Mowinckel
Published in: Cerebral Cortex, Issue 1, 2020, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1101/2020.01.30.926469

Self-reported sleep relates to microstructural hippocampal decline in β-amyloid positive adults beyond genetic risk

Author(s): Håkon Grydeland; Donatas Sederevicius; Yunpeng Wang; David Bartrés-Faz; Lars Bertram; Lars Bertram; Valerija Dobricic; Sandra Düzel; Klaus P. Ebmeier; Ulman Lindenberger; Lars Nyberg; Lars Nyberg; Sara Pudas; Claire E. Sexton; Cristina Solé-Padullés; Øystein Sørensen; Kristine B. Walhovd; Anders M. Fjell
Published in: Sleep, Issue 1, 2021, ISSN 0161-8105
Publisher: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsab110

Reliability and sensitivity of two whole-brain segmentation approaches included in FreeSurfer – ASEG and SAMSEG

Author(s): Donatas Sederevičius, Didac Vidal-Piñeiro, Øystein Sørensen, Koen van Leemput, Juan Eugenio Iglesias, Adrian V. Dalca, Douglas N. Greve, Bruce Fischl, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell
Published in: NeuroImage, 2021, Page(s) Volume 237, 15 August 2021, 118113, ISSN 1095-9572
Publisher: Elsevier
DOI: 10.1016/j.neuroimage.2021.118113

A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects

Author(s): Øystein Sørensen, Kristine B. Walhovd, Anders M. Fjell
Published in: NeuroImage, Issue 226, 2021, Page(s) 117596, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117596

Whole-brain connectivity during encoding: age-related differences and associations with cognitive and brain structural decline

Author(s): Elettra Capogna; Markus H Sneve; Liisa Raud; Line Folvik; Hedda T Ness; Kristine B Walhovd; Anders M Fjell; Didac Vidal-Piñeiro
Published in: Cerebral Cortex, Issue 1, 2022, Page(s) Pages 68–82, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhac053

Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable

Author(s): Kristine B. Walhovd, Anne Cecilie Sjøli Bråthen, Matthew S. Panizzon, Athanasia M. Mowinckel, Øystein Sørensen, Ann-Marie G. de Lange, Stine Kleppe Krogsrud, Asta Håberg, Carol E. Franz, William S. Kremen, Anders M. Fjell
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-78225-1

Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status

Author(s): Stine K. Krogsrud, Athanasia M. Mowinckel, Donatas Sederevicius, Didac Vidal-Piñeiro, Inge K. Amlien, Yunpeng Wang, Øystein Sørensen, Kristine B. Walhovd, Anders M. Fjell
Published in: Developmental Cognitive Neuroscience, 2021, Page(s) Volume 51, October 2021, 100997, ISSN 1878-9307
Publisher: Elsevier
DOI: 10.1016/j.dcn.2021.100997

Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium

Author(s): Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Andreas M Brandmaier, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Paolo Ghisletta, Ane-Victoria Idland, Tim C Kietzmann, Rogier A Kievit, Simone Kühn, Ulman Lindenberger, Fredrik Magnussen, Didac Macià, Athanasia M Mowinckel, Lars Nyberg, Claire E Sexton, Cristina Solé-Padullés, Sara
Published in: Cerebral Cortex, Issue 31/4, 2020, Page(s) 1953-1969, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhaa332

Sustained upregulation of widespread hippocampal–neocortical coupling following memory encoding

Author(s): Line Folvik; Markus H Sneve; Hedda T Ness; Didac Vidal-Piñeiro; Liisa Raud; Oliver M Geier; Kristine B Walhovd; Anders M Fjell
Published in: Cerebral Cortex, Issue 8, 2023, Page(s) Pages 4844–4858, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhac384

Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan

Author(s): Håkon Grydeland; Petra E. Vértes; František Váša; Rafael Romero Garcia; Kirstie Whitaker; Aaron Alexander-Bloch; Atle Bjørnerud; Ameera X. Patel; Donatas Sederevicius; Christian K. Tamnes; Lars T. Westlye; Simon R. White; Kristine B. Walhovd; Anders M. Fjell; Edward T. Bullmore
Published in: Cerebral Cortex, Issue 1, 2019, Page(s) 1369–1381, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1101/314195

Hippocampal-cortical functional connectivity during memory encoding and retrieval

Author(s): Raud L, Sneve MH, Vidal-Piñeiro D, Sørensen Ø, Folvik L, Ness HT, Mowinckel AM, Grydeland H, Walhovd KB, Fjell AM.
Published in: NeuroImage, 2023, Page(s) Volume 279, 1 October 2023, 120309, ISSN 1095-9572
Publisher: Elsevier
DOI: 10.1016/j.neuroimage.2023.120309

Reduced Hippocampal-Striatal Interactions during Formation of Durable Episodic Memories in Aging.

Author(s): Hedda Ness; Line Folvik; Markus Handal Sneve; Didac Vidal-Piñeiro; Liisa Raud; Oliver Geier; Lars Nyberg; Kristine B. Walhovd; Kristine B. Walhovd; Anders M. Fjell; Anders M. Fjell
Published in: Cerebral Cortex, Issue 1, 2021, Page(s) Pages 2358–2372, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhab331

Meta-analysis of generalized additive models in neuroimaging studies

Author(s): Øystein Sørensen, Andreas M. Brandmaier, Dídac Macià, Klaus Ebmeier, Paolo Ghisletta, Rogier A. Kievit, Athanasia M. Mowinckel, Kristine B. Walhovd, Rene Westerhausen, Anders Fjell
Published in: NeuroImage, Issue 224, 2021, Page(s) 117416, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117416

Brain aging differs with cognitive ability regardless of education

Author(s): Kristine B. Walhovd; Lars Nyberg; Ulman Lindenberger; Inge K. Amlien; Øystein Sørensen; Yunpeng Wang; Athanasia M. Mowinckel; Rogier A. Kievit; Klaus P. Ebmeier; David Bartrés-Faz; Simone Kühn; Carl-Johan Boraxbekk; Paolo Ghisletta; Kathrine Skak Madsen; Willliam F. C. Baaré; Enikő Zsoldos; Fredrik Magnussen; Didac Vidal-Piñeiro; Brenda Penninx; Anders M. Fjell
Published in: Walhovd , K B , Nyberg , L , Lindenberger , U , Amlien , I K , Sørensen , Ø , Wang , Y , Mowinckel , A M , Kievit , R A , Ebmeier , K P , Bartrés-Faz , D , Kühn , S , Boraxbekk , C-J , Ghisletta , P , Madsen , K S , Baaré , W F C , Zsoldos , E , Magnussen , F , Vidal-Piñeiro , D , Penninx , B & Fjell , A M 2022 , ' Brain aging differs with cognitive ability regardless of education ' , Scient, Issue 11, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-17727-6

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease

Author(s): James M Roe; Didac Vidal-Piñeiro; Øystein Sørensen; Andreas M. Brandmaier; Sandra Düzel; Hector A. Gonzalez; Rogier A. Kievit; Ethan Knights; Simone Kühn; Simone Kühn; Ulman Lindenberger; Athanasia M. Mowinckel; Lars Nyberg; Denise C. Park; Sara Pudas; Melissa M. Rundle; Kristine B. Walhovd; Kristine B. Walhovd; Anders M. Fjell; Anders M. Fjell; René Westerhausen; Australian Imaging Biomark
Published in: Nature Communications, Issue 1, 2021, Page(s) Vol 12, Iss 1, Pp 1-11 (2021), ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21057-y

Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change

Author(s): Didac Vidal-Piñeiro; Yunpeng Wang; Stine K. Krogsrud; Inge K Amlien; William Fc Baaré; David Bartrés-Faz; Lars Bertram; Lars Bertram; Andreas M. Brandmaier; Christian A. Drevon; Sandra Düzel; Klaus P. Ebmeier; Richard N. Henson; Carme Junqué; Rogier A. Kievit; Rogier A. Kievit; Simone Kühn; Esten Leonardsen; Ulman Lindenberger; Kathrine Skak Madsen; Fredrik Magnussen; Athanasia M. Mowinckel;
Published in: eLife, Issue 9, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.69995

Neural correlates of durable memories across the adult lifespan: brain activity at encoding and retrieval

Author(s): Didac Vidal-Piñeiro, Markus H. Sneve, Andreas B. Storsve, James M. Roe, Kristine B. Walhovd, Anders M. Fjell
Published in: Neurobiology of Aging, Issue 60, 2017, Page(s) 20-33, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.08.017

Maintained Frontal Activity Underlies High Memory Function Over 8 Years in Aging

Author(s): Didac Vidal-Piñeiro, Markus H Sneve, Lars H Nyberg, Athanasia M Mowinckel, Donatas Sederevicius, Kristine B Walhovd, Anders M Fjell
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy177

Continuity and Discontinuity in Human Cortical Development and Change From Embryonic Stages to Old Age

Author(s): Anders M Fjell, Chi-Hua Chen, Donatas Sederevicius, Markus H Sneve, Håkon Grydeland, Stine K Krogsrud, Inge Amlien, Lia Ferschmann, Hedda Ness, Line Folvik, Dani Beck, Athanasia M Mowinckel, Christian K Tamnes, René Westerhausen, Asta K Håberg, Anders M Dale, Kristine B Walhovd
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy266

High-Expanding Regions in Primate Cortical Brain Evolution Support Supramodal Cognitive Flexibility

Author(s): Markus H Sneve, Håkon Grydeland, Marcello G P Rosa, Tomáš Paus, Tristan Chaplin, Kristine Walhovd, Anders M Fjell
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy268

Development and Decline of the Hippocampal Long-Axis Specialization and Differentiation During Encoding and Retrieval of Episodic Memories

Author(s): Espen Langnes, Didac Vidal-Piñeiro, Markus H Sneve, Inge K Amlien, Kristine B Walhovd, Anders M Fjell
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy209

The Lifespan Trajectory of the Encoding-Retrieval Flip: A Multimodal Examination of Medial Parietal Cortex Contributions to Episodic Memory

Author(s): Inge K. Amlien, Markus H. Sneve, Didac Vidal-Piñeiro, Kristine B. Walhovd, Anders M. Fjell
Published in: The Journal of Neuroscience, Issue 38/40, 2018, Page(s) 8666-8679, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1702-17.2018

Volumetric and microstructural regional changes of the hippocampus underlying development of recall performance after extended retention intervals

Author(s): Anders M. Fjell, Markus H. Sneve, Donatas Sederevicius, Øystein Sørensen, Stine K. Krogsrud, Athanasia M. Mowinckel, Kristine B. Walhovd
Published in: Developmental Cognitive Neuroscience, Issue 40, 2019, Page(s) 100723, ISSN 1878-9293
Publisher: Elsevier BV
DOI: 10.1016/j.dcn.2019.100723

Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium

Author(s): Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Didac Maciá Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, G
Published in: Sleep, 2019, ISSN 0161-8105
Publisher: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsz280

Elaboration Benefits Source Memory Encoding Through Centrality Change

Author(s): Inge K. Amlien, Markus H. Sneve, Didac Vidal-Piñeiro, Kristine B. Walhovd, Anders M. Fjell
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-39999-1

Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression

Author(s): Anders M Fjell, Donatas Sederevicius, Markus H Sneve, Ann-Marie Glasø de Lange, Anne CecilieSjøli Bråthen, Ane-Victoria Idland, Leiv Otto Watne, Yunpeng Wang, Céline Reinbold, Valerija Dobricic, Fabian Kilpert, Kaj Blennow, Henrik Zetterbergj, Shengjun Hong, Lars Bertram, Kristine B Walhovd
Published in: Cerebral Cortex, Issue 30/4, 2019, Page(s) 2144-2156, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz228

Anterior and posterior hippocampus macro‐ and microstructure across the lifespan in relation to memory—A longitudinal study

Author(s): Espen Langnes, Markus H. Sneve, Donatas Sederevicius, Inge K. Amlien, Kristine B. Walhovd, Anders M. Fjell
Published in: Hippocampus, Issue 21 Jan 2020, 2020, Page(s) 1-15, ISSN 1050-9631
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hipo.23189

Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan

Author(s): Håkon Grydeland, Petra E Vértes, František Váša, Rafael Romero-Garcia, Kirstie Whitaker, Aaron F Alexander-Bloch, Atle Bjørnerud, Ameera X Patel, Donatas Sederevičius, Christian K Tamnes, Lars T Westlye, Simon R White, Kristine B Walhovd, Anders M Fjell, Edward T Bullmore
Published in: Cerebral Cortex, Issue 29/3, 2018, Page(s) 1369-1381, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy330

Cellular correlates of cortical thinning throughout the lifespan

Author(s): Didac Vidal-Pineiro, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen, Kristine B. Walhovd, Tomas Paus, Anders M. Fjell
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-78471-3

Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults

Author(s): Didac Vidal-Piñeiro, Øystein Sørensen, Kaj Blennow, Elettra Capogna, Nathalie Bodd Halaas, Ane-Victoria Idland, Athanasia Monica Mowinckel, Joana Braga Pereira, Leiv Otto Watne, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell
Published in: Neurobiology of Ageing, 2022, Page(s) Volume 116, August 2022, Pages 80-91, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2022.04.010

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

Author(s): Anders M. Fjell; Anders M. Fjell; Håkon Grydeland; Yunpeng Wang; Inge K Amlien; David Bartrés-Faz; Andreas M. Brandmaier; Sandra Düzel; Jeremy A. Elman; Carol E. Franz; Asta Håberg; Tim C. Kietzmann; Rogier A. Kievit; William S. Kremen; William S. Kremen; Stine K. Krogsrud; Simone Kühn; Ulman Lindenberger; Dídac Macià; Athanasia M. Mowinckel; Lars Nyberg; Lars Nyberg; Matthew S. Panizzon; C
Published in: eLife, Issue 1, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.66466

Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers – in cognitively unimpaired older adults

Author(s): Elettra Capogna, Leiv Otto Watne, Øystein Sørensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Piñeiro
Published in: Brain, Behavior, and Immunity, 2023, Page(s) Volume 113, October 2023, Pages 56-65, ISSN 1090-2139
Publisher: Elsevier
DOI: 10.1016/j.bbi.2023.06.027

Monographic books (1)

The Cambridge Handbook of Cognitive Aging

Author(s): Anders M. Fjell, Kristine B. Walhovd
Published in: 2020, ISBN 9781108552684
Publisher: Cambridge University Press