Extracellular Vesicle-Internalizing Receptors (EVIRs) for Cancer ImmunoGeneTherapy

Project Information

EVOLVE

Grant agreement ID: 725051

DOI

10.3030/725051

Project closed

EC signature date 16 December 2016

Start date 1 July 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 958 919,00

EU contribution

€ 1 958 919,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Author(s): Abhishek S Kashyap, Martina Schmittnaegel, Nicolò Rigamonti, Daniela Pais-Ferreira, Philipp Mueller, Melanie Buchi, Chia-Huey Ooi, Matthias Kreuzaler, Petra Hirschmann, Alan Guichard, Natascha Rieder, Ruben Bill, Frank Herting, Yvonne Kienast, Stefan Dirnhofer, Christian Klein, Sabine Hoves, Carola H Ries, Emily Corse, Michele De Palma, Alfred Zippelius
Published in: Proc Natl Acad Sci U S A, Issue 117/1, 2020, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1902145116

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Author(s): Jeremiah Bernier-Latmani, Christophe Cisarovsky, Samantha Mahfoud, Simone Ragusa, Isabelle Dupanloup, David Barras, François Renevey, Sina Nassiri, Pascale Anderle, Mario Leonardo Squadrito, Stefanie Siegert, Suzel Davanture, Alejandra González-Loyola, Nadine Fournier, Sanjiv A Luther, Rui Benedito, Philippe Valet, Bin Zhou, Michele De Palma, Mauro Delorenzi, Christine Sempoux, Tatiana V Petrova
Published in: Nature Cardiovascular Research, Issue 1/5, 2022, ISSN 2731-0590
Publisher: Nature Publishing Group
DOI: 10.1038/s44161-022-00061-5

Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles

Author(s): Yasaman Jahani, Eduardo R. Arvelo, Filiz Yesilkoy, Kirill Koshelev, Chiara Cianciaruso, Michele De Palma, Yuri Kivshar, Hatice Altug
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23257-y

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Author(s): Simone Ragusa, Borja Prat-Luri, Alejandra González-Loyola, Sina Nassiri, Mario Leonardo Squadrito, Alan Guichard, Sabrina Cavin, Nikolce Gjorevski, David Barras, Giancarlo Marra, Matthias P. Lutolf, Jean Perentes, Emily Corse, Roberta Bianchi, Laureline Wetterwald, Jaeryung Kim, Guillermo Oliver, Mauro Delorenzi, Michele De Palma, Tatiana V. Petrova
Published in: Journal of Clinical Investigation, Issue 130/3, 2020, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci129558

Disentangling the complexity of tumor-derived extracellular vesicles

Author(s): Tim Beltraminelli, Caleb R Perez, Michele De Palma
Published in: Cell Reports, Issue 35/1, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108960

Perivascular macrophages in health and disease

Author(s): Antonio Lapenna, Michele De Palma, Claire E Lewis
Published in: Nature Reviews Immunology, Issue 18/11, 2018, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-018-0056-9

Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow

Author(s): Florent Duval, Michele De Palma
Published in: Cancer Discovery, Issue 9/7, 2019, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0535

Dendritic cell cross-dressing and tumor immunity

Author(s): Amaia Martinez-Usatorre, Michele De Palma
Published in: Embo Molecular Medicine, Issue 14/10, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216523

Tweaking the DNA of myeloid cells curbs cancer spread

Author(s): Ali Ghasemi, Michele De Palma
Published in: Nature, Issue 579/7798, 2020, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-020-00481-y

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Author(s): Ioanna Keklikoglou, Chiara Cianciaruso, Esra Güç, Mario Leonardo Squadrito, Laura M. Spring, Simon Tazzyman, Lore Lambein, Amanda Poissonnier, Gino B. Ferraro, Caroline Baer, Antonino Cassará, Alan Guichard, M. Luisa Iruela-Arispe, Claire E. Lewis, Lisa M. Coussens, Aditya Bardia, Rakesh K. Jain, Jeffrey W. Pollard, Michele De Palma
Published in: Nature Cell Biology, Issue 21/2, 2019, Page(s) 190-202, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0256-3

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

Author(s): Mario Leonardo Squadrito, Chiara Cianciaruso, Sarah K Hansen, Michele De Palma
Published in: Nature Methods, Issue 15/3, 2018, Page(s) 183-186, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4579

Engineering dendritic cell vaccines to improve cancer immunotherapy

Author(s): Caleb R. Perez, Michele De Palma
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13368-y

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Author(s): Chiara Cianciaruso, Tim Beltraminelli, Florent Duval, Sina Nassiri, Romain Hamelin, André Mozes, Hector Gallart-Ayala, Gerardo Ceada Torres, Bruno Torchia, Carola H. Ries, Julijana Ivanisevic, Michele De Palma
Published in: Cell Reports, Issue 27/10, 2019, Page(s) 3062-3080.e11, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.05.008

T cell-induced CSF1 promotes melanoma resistance to PD1 blockade

Author(s): Natalie J Neubert, Martina Schmittnaegel, Natacha Bordry, Sina Nassiri, Noémie Wald, Christophe Martignier, Laure Tillé, Krisztian Homicsko, William Damsky, Hélène Maby-El Hajjami, Irina Klaman, Esther Danenberg, Kalliopi Ioannidou, Lana Kandalaft, George Coukos, Sabine Hoves, Carola H Ries, Silvia A Fuertes Marraco, Periklis G Foukas, Michele De Palma, Daniel E Speiser
Published in: Science Translational Medicine, Issue 10/436, 2018, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aan3311

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Author(s): Amaia Martinez-Usatorre, Ece Kadioglu, Gael Boivin, Chiara Cianciaruso, Alan Guichard, Bruno Torchia, Nadine Zangger, Sina Nassiri, Ioanna Keklikoglou, Martina Schmittnaegel, Carola H Ries, Etienne Meylan, Michele De Palma
Published in: Science Translational Medicine, Issue 13/606, 2021, ISSN 1946-6242
Publisher: AAAS
DOI: 10.1126/scitranslmed.abd1616

Intellectual Property Rights

Patent (1)

ENGINEERED ANTIGEN PRESENTING CELLS AND USES THEREOF

Application/Publication number: EP 16153966
Date: 2016-02-02
Applicant(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE