Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity

Project Information

TEMUBLYM

Grant agreement ID: 725061

DOI 10.3030/725061

Project closed

EC signature date 29 March 2017

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 866 046,00

EU contribution € 1 866 046,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Publications

Peer reviewed articles (27)

CD38 Defines a Subset of B Cells in Rainbow Trout Kidney With High IgM Secreting Capacities

Author(s): Diana Martín, Pedro Perdiguero, Esther Morel, Irene Soleto, J German Herranz-Jusdado, Luis A Ramón, Beatriz Abós, Tiehui Wang, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 16643224, 2021, Page(s) 773888, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.773888

Mucosal and systemic immune effects of Bacillus subtilis in rainbow trout (Oncorhynchus mykiss)

Author(s): F. Docando, N. Nuñez-Ortiz, C.R. Serra, P. Arense, P. Enes, A. Oliva-Teles, P. Díaz-Rosales, C. Tafalla
Published in: Fish & Shellfish Immunology, Issue 10504648, 2022, Page(s) 142-155, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2022.03.040

Diversity of Rainbow Trout Blood B Cells Revealed by Single Cell RNA Sequencing

Author(s): Pedro Perdiguero, Esther Morel, Carolina Tafalla
Published in: Biology, Issue 10/6, 2021, Page(s) 511, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology10060511

Type I Interferon Regulates the Survival and Functionality of B Cells in Rainbow Trout

Author(s): Ottavia Benedicenti, Tiehui Wang, Esther Morel, Christopher J. Secombes, Irene Soleto, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.01494

Aeromonas salmonicida activates rainbow trout IgM+ B cells signalling through Toll like receptors

Author(s): Irene Soleto, Esther Morel, Estefanía Muñoz-Atienza, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73999-w

Search for effective oral adjuvants for rainbow trout (Oncorhynchus mykiss)

Author(s): Felix Docando; Paula Arense; Alba Martín-Martín; Tiehui Wang; Carolina Tafalla; Patricia Díaz-Rosales
Published in: Fish & Shellfish Immunology, Issue 10504648, 2022, Page(s) 419-424, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2022.07.039

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish

Author(s): Pedro Perdiguero, Maria C. Goméz-Esparza, Diana Martín, Steve Bird, Irene Soleto, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.596975

Passive Immunization Delays Disease Outcome in Gilthead Sea Bream Infected With Enteromyxum leei (Myxozoa), Despite the Moderate Changes in IgM and IgT Repertoire

Author(s): Amparo Picard-Sánchez; Itziar Estensoro; Pedro Perdiguero; Del Pozo R; Carolina Tafalla; MCarla Piazzon; Ariadna Sitjà-Bobadilla
Published in: Frontiers in Immunology, Issue 16643224, 2020, Page(s) 581361, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.581361

Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM + B Cells and Mammalian B1 Cells

Author(s): Beatriz Abós, Steve Bird, Aitor G. Granja, Esther Morel, Juan A. More Bayona, Daniel R. Barreda, Carolina Tafalla
Published in: The Journal of Immunology, Issue 201/2, 2018, Page(s) 465-480, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1701546

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Author(s): Carolina Tafalla, Aitor G. Granja
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01285

Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum

Author(s): Estefanía Muñoz-Atienza, Carlos Távara, Patricia Díaz-Rosales, Luis Llanco, Enrique Serrano-Martínez, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 86, 2019, Page(s) 25-34, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2018.11.027

Role of teleost B cells in viral immunity

Author(s): Patricia Díaz-Rosales, Estefanía Muñoz-Atienza, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 86, 2019, Page(s) 135-142, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2018.11.039

Regulation of IgM+ B Cell Activities by Rainbow Trout APRIL Reveals Specific Effects of This Cytokine in Lower Vertebrates

Author(s): Irene Soleto, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01880

Dysregulation of B Cell Activity During Proliferative Kidney Disease in Rainbow Trout

Author(s): Beatriz Abos, Itziar Estensoro, Pedro Perdiguero, Marc Faber, Yehfang Hu, Patricia Díaz Rosales, Aitor G. Granja, Christopher J. Secombes, Jason W. Holland, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01203

CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgM+ B Cells in Rainbow Trout

Author(s): Rocío Simón, Patricia Díaz-Rosales, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 10, 2019, Page(s) 584, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.00584

Identification of CD8α+ dendritic cells in rainbow trout (Oncorhynchus mykiss) intestine

Author(s): Irene Soleto, Aitor G. Granja, Rocío Simón, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 89, 2019, Page(s) 309-318, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2019.04.001

Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L

Author(s): Aitor G. Granja, Pedro Perdiguero, Alba Martín-Martín, Patricia Díaz-Rosales, Irene Soleto, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.02902

Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Author(s): Pedro Perdiguero, Alba Martín-Martín, Ottavia Benedicenti, Patricia Díaz-Rosales, Esther Morel, Estefanía Muñoz-Atienza, Mónica García-Flores, Rocío Simón, Irene Soleto, Andrea Cerutti, Carolina Tafalla
Published in: Cell Reports, Issue 29/13, 2019, Page(s) 4223-4235.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.11.101

Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM+ B cells

Author(s): Beatriz Abos, Tiehui Wang, Christopher J. Secombes, Carolina Tafalla
Published in: Developmental & Comparative Immunology, 2020, Page(s) 103752, ISSN 0145-305X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2020.103752

Rainbow trout mount a robust specific immune response upon anal administration of thymus-independent antigens

Author(s): Alba Martín-Martín, Rocío Simón, Beatriz Abós, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Developmental & Comparative Immunology, Issue 109, 2020, Page(s) 103715, ISSN 0145-305X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2020.103715

The Ancient Cytokine BAFF- and APRIL-like Molecule Regulates the Functionality of Teleost IgM + B Cells Similarly to BAFF and APRIL

Author(s): Rocío Simón, Patricia Díaz-Rosales, Carolina Tafalla
Published in: The Journal of Immunology, Issue 206/8, 2021, Page(s) 1765-1775, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2000762

Functional and Phenotypic Characterization of B Cells in the Teleost Adipose Tissue

Author(s): Rocío Simón, Alba Martín-Martín, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 16643224, 2022, Page(s) 868551., ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.868551

Mechanisms Used by Probiotics to Confer Pathogen Resistance to Teleost Fish

Author(s): Rocío Simón, Félix Docando, Noelia Nuñez-Ortiz, Carolina Tafalla, Patricia Díaz-Rosales
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.653025

Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish

Author(s): Pedro Perdiguero, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: iScience, Issue 24/6, 2021, Page(s) 102615, ISSN 2589-0042
Publisher: Science
DOI: 10.1016/j.isci.2021.102615

Pro-Inflammatory and B Cell Regulating Capacities of TWEAK in Rainbow Trout (Oncorhynchus mykiss)

Author(s): Beatriz Abós, Elena Pérez-Fernández, Esther Morel, Pedro Perdiguero, and Carolina Tafalla
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.748836

A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout

Author(s): Chris Bailey; Jason W. Holland; Christopher J. Secombes; Carolina Tafalla
Published in: Parasite Immunology, Issue 01419838, 2020, Page(s) 12730, ISSN 0141-9838
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pim.12730

Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish

Author(s): Estefanía Muñoz-Atienza, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.622377

Intellectual Property Rights

Registered design (2)

PLASMID ENCODING B-CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) AND USES OF SAME IN THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES IN FISH

Application/Publication number: PCT/ES2020/070721 PCT/ES2020/070721
Date: 2020-07-05

PLASMID ENCODING B-CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) AND USES OF SAME IN THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES IN FISH

Application/Publication number: PCT/ES2020/070721 PCT/ES2020/070721
Date: 2020-07-05
Applicant(s): INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA