Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity

Project Information

TEMUBLYM

Grant agreement ID: 725061

DOI

10.3030/725061

Project closed

EC signature date 29 March 2017

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 866 046,00

EU contribution

€ 1 866 046,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

CD38 Defines a Subset of B Cells in Rainbow Trout Kidney With High IgM Secreting Capacities

Author(s): Diana Martín, Pedro Perdiguero, Esther Morel, Irene Soleto, J German Herranz-Jusdado, Luis A Ramón, Beatriz Abós, Tiehui Wang, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 773888, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.773888

Mucosal and systemic immune effects of Bacillus subtilis in rainbow trout (Oncorhynchus mykiss)

Author(s): F. Docando, N. Nuñez-Ortiz, C.R. Serra, P. Arense, P. Enes, A. Oliva-Teles, P. Díaz-Rosales, C. Tafalla
Published in: Fish & Shellfish Immunology, Issue 124, 2022, Page(s) 142-155, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2022.03.040

Diversity of Rainbow Trout Blood B Cells Revealed by Single Cell RNA Sequencing

Author(s): Pedro Perdiguero, Esther Morel, Carolina Tafalla
Published in: Biology, Issue 10/6, 2021, Page(s) 511, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology10060511

Type I Interferon Regulates the Survival and Functionality of B Cells in Rainbow Trout

Author(s): Ottavia Benedicenti, Tiehui Wang, Esther Morel, Christopher J. Secombes, Irene Soleto, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 1494, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01494

Aeromonas salmonicida activates rainbow trout IgM+ B cells signalling through Toll like receptors

Author(s): Irene Soleto, Esther Morel, Estefanía Muñoz-Atienza, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 16810, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73999-w

Search for effective oral adjuvants for rainbow trout (Oncorhynchus mykiss)

Author(s): Felix Docando; Paula Arense; Alba Martín-Martín; Tiehui Wang; Carolina Tafalla; Patricia Díaz-Rosales
Published in: Fish & Shellfish Immunology, Issue 128, 2022, Page(s) 419-424, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2022.07.039

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish

Author(s): Pedro Perdiguero, Maria C. Goméz-Esparza, Diana Martín, Steve Bird, Irene Soleto, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 596975, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.596975

Passive Immunization Delays Disease Outcome in Gilthead Sea Bream Infected With Enteromyxum leei (Myxozoa), Despite the Moderate Changes in IgM and IgT Repertoire

Author(s): Amparo Picard-Sánchez; Itziar Estensoro; Pedro Perdiguero; Del Pozo R; Carolina Tafalla; MCarla Piazzon; Ariadna Sitjà-Bobadilla
Published in: Frontiers in Immunology, Issue 11/11, 2020, Page(s) 581361, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.581361

Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM + B Cells and Mammalian B1 Cells

Author(s): Beatriz Abós, Steve Bird, Aitor G. Granja, Esther Morel, Juan A. More Bayona, Daniel R. Barreda, Carolina Tafalla
Published in: The Journal of Immunology, Issue 201/2, 2018, Page(s) 465-480, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1701546

Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish

Author(s): Carolina Tafalla, Aitor G. Granja
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01285

Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum

Author(s): Estefanía Muñoz-Atienza, Carlos Távara, Patricia Díaz-Rosales, Luis Llanco, Enrique Serrano-Martínez, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 86, 2019, Page(s) 25-34, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2018.11.027

Role of teleost B cells in viral immunity

Author(s): Patricia Díaz-Rosales, Estefanía Muñoz-Atienza, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 86, 2019, Page(s) 135-142, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2018.11.039

Regulation of IgM+ B Cell Activities by Rainbow Trout APRIL Reveals Specific Effects of This Cytokine in Lower Vertebrates

Author(s): Irene Soleto, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 1880, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01880

Dysregulation of B Cell Activity During Proliferative Kidney Disease in Rainbow Trout

Author(s): Beatriz Abos, Itziar Estensoro, Pedro Perdiguero, Marc Faber, Yehfang Hu, Patricia Díaz Rosales, Aitor G. Granja, Christopher J. Secombes, Jason W. Holland, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 1203, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01203

CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgM+ B Cells in Rainbow Trout

Author(s): Rocío Simón, Patricia Díaz-Rosales, Esther Morel, Diana Martín, Aitor G. Granja, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 10, 2019, Page(s) 584, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.00584

Identification of CD8α+ dendritic cells in rainbow trout (Oncorhynchus mykiss) intestine

Author(s): Irene Soleto, Aitor G. Granja, Rocío Simón, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Fish & Shellfish Immunology, Issue 89, 2019, Page(s) 309-318, ISSN 1050-4648
Publisher: Academic Press
DOI: 10.1016/j.fsi.2019.04.001

Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L

Author(s): Aitor G. Granja, Pedro Perdiguero, Alba Martín-Martín, Patricia Díaz-Rosales, Irene Soleto, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 10, 2019, Page(s) 2902, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.02902

Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Author(s): Pedro Perdiguero, Alba Martín-Martín, Ottavia Benedicenti, Patricia Díaz-Rosales, Esther Morel, Estefanía Muñoz-Atienza, Mónica García-Flores, Rocío Simón, Irene Soleto, Andrea Cerutti, Carolina Tafalla
Published in: Cell Reports, Issue 29/13, 2019, Page(s) 4223-4235.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.11.101

Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM+ B cells

Author(s): Beatriz Abos, Tiehui Wang, Christopher J. Secombes, Carolina Tafalla
Published in: Developmental & Comparative Immunology, 2020, Page(s) 103752, ISSN 0145-305X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2020.103752

Rainbow trout mount a robust specific immune response upon anal administration of thymus-independent antigens

Author(s): Alba Martín-Martín, Rocío Simón, Beatriz Abós, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Developmental & Comparative Immunology, Issue 109, 2020, Page(s) 103715, ISSN 0145-305X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.dci.2020.103715

The Ancient Cytokine BAFF- and APRIL-like Molecule Regulates the Functionality of Teleost IgM + B Cells Similarly to BAFF and APRIL

Author(s): Rocío Simón, Patricia Díaz-Rosales, Carolina Tafalla
Published in: The Journal of Immunology, Issue 206/8, 2021, Page(s) 1765-1775, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2000762

Functional and Phenotypic Characterization of B Cells in the Teleost Adipose Tissue

Author(s): Rocío Simón, Alba Martín-Martín, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 13, 2022, Page(s) 868551, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.868551

Mechanisms Used by Probiotics to Confer Pathogen Resistance to Teleost Fish

Author(s): Rocío Simón, Félix Docando, Noelia Nuñez-Ortiz, Carolina Tafalla, Patricia Díaz-Rosales
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 653025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.653025

Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish

Author(s): Pedro Perdiguero, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla
Published in: iScience, Issue 24/6, 2021, Page(s) 102615, ISSN 2589-0042
Publisher: Elsevier Inc
DOI: 10.1016/j.isci.2021.102615

Pro-Inflammatory and B Cell Regulating Capacities of TWEAK in Rainbow Trout (Oncorhynchus mykiss)

Author(s): Beatriz Abós, Elena Pérez-Fernández, Esther Morel, Pedro Perdiguero, and Carolina Tafalla
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 748836, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.748836

A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout

Author(s): Chris Bailey; Jason W. Holland; Christopher J. Secombes; Carolina Tafalla
Published in: Parasite Immunology, Issue 01419838, 2020, Page(s) 12730, ISSN 0141-9838
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pim.12730

Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish

Author(s): Estefanía Muñoz-Atienza, Patricia Díaz-Rosales, Carolina Tafalla
Published in: Frontiers in Immunology, Issue 11, 2021, Page(s) 622377, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.622377

Intellectual Property Rights

Registered design (2)

PLASMID ENCODING B-CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) AND USES OF SAME IN THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES IN FISH

Application/Publication number: PCT/ES2020/070721 PCT/ES2020/070721
Date: 2020-07-05
Applicant(s): INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA

PLASMID ENCODING B-CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) AND USES OF SAME IN THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES IN FISH

Application/Publication number: PCT/ES2020/070721 PCT/ES2020/070721
Date: 2020-07-05
Applicant(s): AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS