Hold it or let it go: a niche decision on cancer growth

Project Information

WHOLENICHE

Grant agreement ID: 725492

DOI 10.3030/725492

Project closed

EC signature date 30 March 2017

Start date 1 April 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes

Author(s): Anisha Ramessur, Bana Ambasager, Iker Valle Aramburu, Freddie Peakman, Kelly Gleason, Christoph Lehmann, Venizelos Papayannopoulos, Raoul Charles Coombes, and Ilaria Malanchi
Published in: Breast Cancer Research, 2023, ISSN 1465-542X
Publisher: Springer Nature
DOI: 10.1186/s13058-023-01707-3

Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility

Author(s): Stefanie K Wculek, Victoria L Bridgeman, Freddie Peakman, Ilaria Malanchi
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell press
DOI: 10.1016/j.isci.2020.101277

Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth

Author(s): Anna Perdrix Rosell; Oscar Maiques; Joshua Alexander James Martin; Probir Chakravarty; Luigi Ombrato; Victoria Sanz-Moreno; Ilaria Malanchi
Published in: Cancer Letters, Issue 1, 2022, ISSN 0304-3835
Publisher: Elsevier BV
DOI: 10.1016/j.canlet.2022.215800

Metastatic-niche labelling reveals parenchymal cells with stem features

Author(s): Luigi Ombrato; Emma Nolan; Ivana Kurelac; Ivana Kurelac; Antranik Mavousian; Victoria L. Bridgeman; Ivonne Heinze; Probir Chakravarty; Stuart Horswell; Estela Gonzalez-Gualda; Giulia Matacchione; Anne Weston; Joanna Kirkpatrick; Ehab Husain; Valerie Speirs; Lucy M. Collinson; Alessandro Ori; Joo-Hyeon Lee; Ilaria Malanchi
Published in: Metastatic-niche labelling reveals parenchymal cells with stem features, Issue 1, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1487-6

Generation of neighbor-labeling cells to study intercellular interactions in vivo

Author(s): Luigi Ombrato, Emma Nolan , Diana Passaro , Ivana Kurelac , Victoria L Bridgeman , Alexander Waclawiczek , Delfim Duarte , Cristina Lo Celso , Dominique Bonnet , Ilaria Malanchi
Published in: Nature Protocols, 2020, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-00438-5

Lung adenocarcinoma promotion by air pollutants

Author(s): "William Hill,#1 Emilia L. Lim,#1,2,127 Clare E. Weeden,#1 Claudia Lee,1,2,3 Marcellus Augustine,1,2,3,4 Kezhong Chen,2,5 Feng-Che Kuan,6,7 Fabio Marongiu,8,9 Edward J. Evans, Jr,8 David A. Moore,1,2,10 Felipe S. Rodrigues,11 Oriol Pich,1 Bjorn Bakker,1 Hongui Cha,2,12 Renelle Myers,13 Febe van Maldegem,14,15 Jesse Boumelha,14 Selvaraju Veeriah,2 Andrew Rowan,1 Cristina Naceur-Lombardelli,2 Takahir"
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05874-3

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

Author(s): Diana Passaro, Manuel Garcia-Albornoz, Giovanni Diana, Probir Chakravarty, Linda Ariza-McNaughton, Antoniana Batsivari, Clara Borràs-Eroles, Ander Abarrategi, Alexander Waclawiczek, Luigi Ombrato, Ilaria Malanchi, John Gribben, Dominique Bonnet
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109119

Connecting the dots: Neutrophils at the interface of tissue regeneration and cancer

Author(s): Ilaria Malanchi; Emma Nolan
Published in: Seminars in Immunology, Issue 1, 2021, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2022.101598

Neutrophil phenotypes and functions in cancer: A consensus statement

Author(s): Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Published in: Journal of Experimental Medicine, Issue 1, 2022, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220011

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Author(s): Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, I
Published in: Nature Communications, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08839-1

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

Author(s): Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewnath, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell , Peter Faull, Rebecca Carter, Ilaria Malanchi
Published in: Nature Cancer, 2022, ISSN 2662-1347
Publisher: nature
DOI: 10.1038/s43018-022-00336-7

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

Author(s): Patricia Altea-Manzano, Ginevra Doglioni , Yawen Liu , Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo
Published in: Nature Cancer, 2023, ISSN 2662-1347
Publisher: Nature Publishing group
DOI: 10.1038/s43018-023-00513-2

Book chapters (1)

Mechanisms of Organ-Specific Metastasis of Breast Cancer

Author(s): Emma Nolan, Yibin Kang, Ilaria Malanchi
Published in: 2023
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041326