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The chemistry and physics of RNP granules: how they form, age and cause disease

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Publications

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

Author(s): Christiane Iserman, Christine Desroches Altamirano, Ceciel Jegers, Ulrike Friedrich, Taraneh Zarin, Anatol W. Fritsch, Matthäus Mittasch, Antonio Domingues, Lena Hersemann, Marcus Jahnel, Doris Richter, Ulf-Peter Guenther, Matthias W. Hentze, Alan M. Moses, Anthony A. Hyman, Günter Kramer, Moritz Kreysing, Titus M. Franzmann, Simon Alberti
Published in: Cell, 181/4, 2020, Page(s) 818-831.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.04.009

Protein phase separation and its role in tumorigenesis

Author(s): Shan Jiang, Johan Bourghardt Fagman, Changyan Chen, Simon Alberti, Beidong Liu
Published in: eLife, 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60264

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Author(s): Shovamayee Maharana, Jie Wang, Dimitrios K. Papadopoulos, Doris Richter, Andrey Pozniakovsky, Ina Poser, Marc Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M. Franzmann, Marcus Jahnel, Lara Marrone, Young-Tae Chang, Jared Sterneckert, Pavel Tomancak, Anthony A. Hyman, Simon Alberti
Published in: Science, 360/6391, 2018, Page(s) 918-921, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar7366

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Author(s): Jie Wang, Jeong-Mo Choi, Alex S. Holehouse, Hyun O. Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis Lemaitre, Andrei Pozniakovsky, David Drechsel, Ina Poser, Rohit V. Pappu, Simon Alberti, Anthony A. Hyman
Published in: Cell, 174/3, 2018, Page(s) 688-699.e16, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.06.006

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Author(s): Laura Mediani, Jordina Guillén‐Boixet, Jonathan Vinet, Titus M Franzmann, Ilaria Bigi, Daniel Mateju, Arianna D Carrà, Federica F Morelli, Tatiana Tiago, Ina Poser, Simon Alberti, Serena Carra
Published in: The EMBO Journal, 38/15, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101341

ALS and FTD: Where RNA metabolism meets protein quality control

Author(s): Jessica Mandrioli, Laura Mediani, Simon Alberti, Serena Carra
Published in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.06.003

Liquid–Liquid Phase Separation in Disease

Author(s): Simon Alberti, Dorothee Dormann
Published in: Annual Review of Genetics, 53/1, 2019, ISSN 0066-4197
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-112618-043527

A User’s Guide for Phase Separation Assays with Purified Proteins

Author(s): Simon Alberti, Shambaditya Saha, Jeffrey B. Woodruff, Titus M. Franzmann, Jie Wang, Anthony A. Hyman
Published in: Journal of Molecular Biology, 430/23, 2018, Page(s) 4806-4820, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.06.038

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

Author(s): Simon Alberti, Amy Gladfelter, Tanja Mittag
Published in: Cell, 176/3, 2019, Page(s) 419-434, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.035

Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

Author(s): Titus M. Franzmann, Simon Alberti
Published in: Journal of Biological Chemistry, 294/18, 2019, Page(s) 7128-7136, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.tm118.001190

Quality Control of Membraneless Organelles

Author(s): Simon Alberti, Serena Carra
Published in: Journal of Molecular Biology, 430/23, 2018, Page(s) 4711-4729, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.05.013

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Author(s): Lara Marrone, Hannes C. A. Drexler, Jie Wang, Priyanka Tripathi, Tania Distler, Patrick Heisterkamp, Eric Nathaniel Anderson, Sukhleen Kour, Anastasia Moraiti, Shovamayee Maharana, Rajat Bhatnagar, T. Grant Belgard, Vadreenath Tripathy, Norman Kalmbach, Zohreh Hosseinzadeh, Valeria Crippa, Masin Abo-Rady, Florian Wegner, Angelo Poletti, Dirk Troost, Eleonora Aronica, Volker Busskamp, Joachim Weis,
Published in: Acta Neuropathologica, 138/1, 2019, Page(s) 67-84, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-01998-x

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Author(s): Jordina Guillén-Boixet, Andrii Kopach, Alex S. Holehouse, Sina Wittmann, Marcus Jahnel, Raimund Schlüßler, Kyoohyun Kim, Irmela R.E.A. Trussina, Jie Wang, Daniel Mateju, Ina Poser, Shovamayee Maharana, Martine Ruer-Gruß, Doris Richter, Xiaojie Zhang, Young-Tae Chang, Jochen Guck, Alf Honigmann, Julia Mahamid, Anthony A. Hyman, Rohit V. Pappu, Simon Alberti, Titus M. Franzmann
Published in: Cell, 181/2, 2020, Page(s) 346-361.e17, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.03.049