The chemistry and physics of RNP granules: how they form, age and cause disease

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

Author(s): Christiane Iserman, Christine Desroches Altamirano, Ceciel Jegers, Ulrike Friedrich, Taraneh Zarin, Anatol W. Fritsch, Matthäus Mittasch, Antonio Domingues, Lena Hersemann, Marcus Jahnel, Doris Richter, Ulf-Peter Guenther, Matthias W. Hentze, Alan M. Moses, Anthony A. Hyman, Günter Kramer, Moritz Kreysing, Titus M. Franzmann, Simon Alberti
Published in: Cell, Issue 181/4, 2020, Page(s) 818-831.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.04.009

Protein products of nonstop mRNA disrupt nucleolar homeostasis

Author(s): Zoe H Davis, Laura Mediani, Francesco Antoniani, Jonathan Vinet, Shuangxi Li, Simon Alberti, Bingwei Lu, Alex S Holehouse, Serena Carra, Onn Brandman
Published in: Cell Stress and Chaperones, Issue 26, 2021, Page(s) 549–561 (2021), ISSN 1466-1268
Publisher: Springer Netherlands
DOI: 10.1007/s12192-021-01200-w

eIF4F is a thermo-sensing regulatory node in the translational heat shock response

Author(s): Christine Desroches Altamirano , Moo-Koo Kang , Mareike A Jordan , Tom Borianne , Irem Dilmen , Maren Gnädig , Alexander von Appen , Alf Honigmann , Titus M Franzmann , Simon Alberti
Published in: Molecular Cell, Issue 2024 Mar 19, 2024, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.02.038

Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process

Author(s): Choudhary, Dhawal; Mediani, Laura; Avellaneda, Mario J; Bjarnason, Sveinn; Alberti, Simon; Boczek, Edgar E; Heidarsson, Pétur O; Mossa, Alessandro; Carra, Serena; Tans, Sander J; Cecconi, Ciro
Published in: Journal of the American Chemical Society (Online) 145 (2023), Issue 28, 2023, Page(s) 15188–15196, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c02022

PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Author(s): Nagaraja Chappidi, Thomas Quail, Simon Doll, Laura T Vogel, Radoslav Aleksandrov, Suren Felekyan, Ralf Kühnemuth, Stoyno Stoynov, Claus A M Seidel, Jan Brugués, Marcus Jahnel, Titus M Franzmann, Simon Alberti
Published in: Cell, Issue Volume 187, Issue 4, 2024, Page(s) 945-961, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.01.015

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Author(s): Simon Alberti, Anthony A Hyman
Published in: Nature Reviews and molecular cell biology, Issue 22 (3), 2021, Page(s) 196–213, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00326-6

Protein phase separation and its role in tumorigenesis

Author(s): Shan Jiang, Johan Bourghardt Fagman, Changyan Chen, Simon Alberti, Beidong Liu
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60264

CAPRIN1 P512L causes aberrant protein aggregation and associates with early-onset ataxia

Author(s): Andrea Delle Vedove; Janani Natarajan; Ginevra Zanni; Matthias Eckenweiler; Anixa Muiños-Bühl; Markus Storbeck; Jordina Guillén Boixet; Sabina Barresi; Simone Pizzi; Irmgard Hölker; Friederike Körber; Titus M. Franzmann; Enrico S. Bertini; Janbernd Kirschner; Simon Alberti; Marco Tartaglia; Brunhilde Wirth
Published in: Cellular and Molecular Life Sciences, Issue Volume 79, article number 526, 2022, ISSN 1420-9071
Publisher: Springer Link
DOI: 10.21203/rs.3.rs-1838998/v1

Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development

Author(s): M. Sankaranarayanan, Ryan J. Emenecker, Elise L. Wilby, Marcus Jahnel, Irmela R.E.A. Trussina, Matt Wayland, Simon Alberti, Alex S. Holehouse, and Timothy T. Weil
Published in: Developmental Cell, Issue Volume 56, Issue 20, 2021, Page(s) 2886-2901.e6, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.09.021

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Author(s): Shovamayee Maharana, Jie Wang, Dimitrios K. Papadopoulos, Doris Richter, Andrey Pozniakovsky, Ina Poser, Marc Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M. Franzmann, Marcus Jahnel, Lara Marrone, Young-Tae Chang, Jared Sterneckert, Pavel Tomancak, Anthony A. Hyman, Simon Alberti
Published in: Science, Issue 360/6391, 2018, Page(s) 918-921, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar7366

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Author(s): Jie Wang, Jeong-Mo Choi, Alex S. Holehouse, Hyun O. Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis Lemaitre, Andrei Pozniakovsky, David Drechsel, Ina Poser, Rohit V. Pappu, Simon Alberti, Anthony A. Hyman
Published in: Cell, Issue 174/3, 2018, Page(s) 688-699.e16, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.06.006

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Author(s): Laura Mediani, Jordina Guillén‐Boixet, Jonathan Vinet, Titus M Franzmann, Ilaria Bigi, Daniel Mateju, Arianna D Carrà, Federica F Morelli, Tatiana Tiago, Ina Poser, Simon Alberti, Serena Carra
Published in: The EMBO Journal, Issue 38/15, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101341

ALS and FTD: Where RNA metabolism meets protein quality control

Author(s): Jessica Mandrioli, Laura Mediani, Simon Alberti, Serena Carra
Published in: Seminars in Cell & Developmental Biology, 2019, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.06.003

Liquid–Liquid Phase Separation in Disease

Author(s): Simon Alberti, Dorothee Dormann
Published in: Annual Review of Genetics, Issue 53/1, 2019, ISSN 0066-4197
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-112618-043527

A User’s Guide for Phase Separation Assays with Purified Proteins

Author(s): Simon Alberti, Shambaditya Saha, Jeffrey B. Woodruff, Titus M. Franzmann, Jie Wang, Anthony A. Hyman
Published in: Journal of Molecular Biology, Issue 430/23, 2018, Page(s) 4806-4820, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.06.038

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

Author(s): Simon Alberti, Amy Gladfelter, Tanja Mittag
Published in: Cell, Issue 176/3, 2019, Page(s) 419-434, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.12.035

Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

Author(s): Titus M. Franzmann, Simon Alberti
Published in: Journal of Biological Chemistry, Issue 294/18, 2019, Page(s) 7128-7136, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.tm118.001190

Quality Control of Membraneless Organelles

Author(s): Simon Alberti, Serena Carra
Published in: Journal of Molecular Biology, Issue 430/23, 2018, Page(s) 4711-4729, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.05.013

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Author(s): Lara Marrone, Hannes C. A. Drexler, Jie Wang, Priyanka Tripathi, Tania Distler, Patrick Heisterkamp, Eric Nathaniel Anderson, Sukhleen Kour, Anastasia Moraiti, Shovamayee Maharana, Rajat Bhatnagar, T. Grant Belgard, Vadreenath Tripathy, Norman Kalmbach, Zohreh Hosseinzadeh, Valeria Crippa, Masin Abo-Rady, Florian Wegner, Angelo Poletti, Dirk Troost, Eleonora Aronica, Volker Busskamp, Joachim Weis,
Published in: Acta Neuropathologica, Issue 138/1, 2019, Page(s) 67-84, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-01998-x

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Author(s): Jordina Guillén-Boixet, Andrii Kopach, Alex S. Holehouse, Sina Wittmann, Marcus Jahnel, Raimund Schlüßler, Kyoohyun Kim, Irmela R.E.A. Trussina, Jie Wang, Daniel Mateju, Ina Poser, Shovamayee Maharana, Martine Ruer-Gruß, Doris Richter, Xiaojie Zhang, Young-Tae Chang, Jochen Guck, Alf Honigmann, Julia Mahamid, Anthony A. Hyman, Rohit V. Pappu, Simon Alberti, Titus M. Franzmann
Published in: Cell, Issue 181/2, 2020, Page(s) 346-361.e17, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.03.049

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

Author(s): Shovamayee Maharana, Stefanie Kretschmer, Susan Hunger, Xiao Yan, David Kuster, Sofia Traikov, Thomas Zillinger, Marc Gentzel, Shobha Elangovan, Padmanava Dasgupta, Nagaraja Chappidi, Nadja Lucas, Katharina Isabell Maser, Henrike Maatz, Alexander Rapp, Virginie Marchand, Young-Tae Chang, Yuri Motorin, Norbert Hubner, Gunther Hartmann, Anthony A Hyman, Simon Alberti, Min Ae Lee-Kirsch
Published in: Molecular Cell, Issue Volume 82, Issue 19, 2022, Page(s) 3712-3728, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.08.031

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

Author(s): Laura Mediani , Francesco Antoniani, Veronica Galli, Jonathan Vinet, Arianna Dorotea Carrà, Ilaria Bigi, Vadreenath Tripathy, Tatiana Tiago, Marco Cimino, Giuseppina Leo, Triana Amen, Daniel Kaganovich, Cristina Cereda, Orietta Pansarasa, Jessica Mandrioli, Priyanka Tripathi, Dirk Troost, Eleonora Aronica, Johannes Buchner, Anand Goswami, Jared Sterneckert, Simon Alberti, Serena Carra
Published in: Embo Reports, Issue Volume 22, Issue 5, 2021, Page(s) e51740, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202051740

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