Determining the instructive tissue signals and the master transcription factors driving Kupffer cell differentiation

Project Information

KupfferCellNiche

Grant agreement ID: 725924

DOI

10.3030/725924

Project closed

EC signature date 18 May 2017

Start date 1 July 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 996 705,00

EU contribution

€ 1 996 705,00

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Author(s): Bosteels Cedric, Liesbet Martens, Martin Guilliams, Simon Tavernier, Bart Lambrecht
Published in: Cell Reports Medicine, 2022, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2022.100833

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Author(s): Charlotte L. Scott, Wouter T’Jonck, Liesbet Martens, Helena Todorov, Dorine Sichien, Bieke Soen, Johnny Bonnardel, Sofie De Prijck, Niels Vandamme, Robrecht Cannoodt, Wouter Saelens, Bavo Vanneste, Wendy Toussaint, Pieter De Bleser, Nozomi Takahashi, Peter Vandenabeele, Sandrine Henri, Clare Pridans, David A. Hume, Bart N. Lambrecht, Patrick De Baetselier, Simon W.F. Milling, Jo A. Van Ginderach
Published in: Immunity, Issue 49/2, 2018, Page(s) 312-325.e5, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.07.004

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

Author(s): Johnny Bonnardel, Wouter T’Jonck, Djoere Gaublomme, Robin Browaeys, Charlotte L. Scott, Liesbet Martens, Bavo Vanneste, Sofie De Prijck, Sergei A. Nedospasov, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Wendy Toussaint, Pieter De Bleser, Inge Mannaerts, Alain Beschin, Leo A. van Grunsven, Bart N. Lambrecht, Tom Taghon, Saskia Lippens, Dirk Elewaut, Yvan Saeys, Martin Guilliams
Published in: Immunity, Issue 51/4, 2019, Page(s) 638-654.e9, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2019.08.017

Establishment and Maintenance of the Macrophage Niche

Author(s): Martin Guilliams, Guilhem R. Thierry, Johnny Bonnardel, Marc Bajenoff
Published in: Immunity, Issue 52/3, 2020, Page(s) 434-451, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.02.015

Developmental and Functional Heterogeneity of Monocytes

Author(s): Martin Guilliams, Alexander Mildner, Simon Yona
Published in: Immunity, Issue 49/4, 2018, Page(s) 595-613, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2018.10.005

Does niche competition determine the origin of tissue-resident macrophages?

Author(s): Martin Guilliams, Charlotte L. Scott
Published in: Nature Reviews Immunology, Issue 17/7, 2017, Page(s) 451-460, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2017.42

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Author(s): Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Ney
Published in: Cell, 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.12.018