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Understanding pathogen, livestock, environment interactions involving bluetongue virus

Objective

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe.
Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies.
PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

Call for proposal

H2020-SFS-2016-2017

See other projects for this call

Sub call

H2020-SFS-2016-2

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Net EU contribution
€ 1 301 601,50
Address
University Park
NG7 2RD Nottingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham

Participants (19)

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
Net EU contribution
€ 383 750,00
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Net EU contribution
€ 12 500,00
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC
France
Net EU contribution
€ 333 365,00
Address
Rue Scheffer 42
75016 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE G CAPORALE
Italy
Net EU contribution
€ 393 875,00
Address
Via Campo Boario
64100 Teramo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
Net EU contribution
€ 290 000,00
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald
ENVIRONMENTAL RESEARCH GROUP OXFORD LIMITED
United Kingdom
Net EU contribution
€ 143 281,25
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Ryelands Grove 10
HR6 8QA Leominster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
West Midlands (England) Herefordshire, Worcestershire and Warwickshire Herefordshire, County of
 
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Net EU contribution
€ 188 705,00
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 203 625,00
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STICHTING WAGENINGEN RESEARCH
Netherlands
Net EU contribution
€ 418 000,00
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 640 438,75
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KIMRON VETERINARY INSTITUTE
Israel
Net EU contribution
€ 87 500,00
Address
Kimron Street 1
50250 Rishon L'tzion
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 172 625,00
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STATENS VETERINAERMEDICINSKA ANSTALT
Sweden
Net EU contribution
€ 230 000,00
Address
Ulls Vaeg 2B
75189 Uppsala
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Östra Sverige Östra Mellansverige Uppsala län
KAFKAS UNIVERSITESI
Turkey
Net EU contribution
€ 110 000,00
Address
Pasacayiri
36100 Kars
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II
Morocco
Net EU contribution
€ 137 500,00
Address
Avenue Allal El Fassi Madinat Al
10101 Rabat
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
Net EU contribution
€ 434 822,50
Address
Ash Road Pirbright
GU24 0NF Woking
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
South East (England) Surrey, East and West Sussex West Surrey
International Livestock Research Institute
Kenya
Net EU contribution
€ 287 851,25
Address
Old Naivasha Rd
00100 Nairobi
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES
Senegal
Net EU contribution
€ 129 861,25
Address
Route Des Hydrocarbures Bel Air
3120 Dakar
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT PASTEUR DE TUNIS
Tunisia
Net EU contribution
€ 140 000,00
Address
Place Pasteur 13
1002 Tunis
Activity type
Research Organisations
Non-EU contribution
€ 0,00