Skip to main content

Understanding pathogen, livestock, environment interactions involving bluetongue virus

Objective

New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe.
Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies.
PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.

Call for proposal

H2020-SFS-2016-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Address
University Park
NG7 2RD Nottingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 301 601,50

Participants (18)

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 396 250
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC
France
EU contribution
€ 333 365
Address
Rue Scheffer 42
75016 Paris
Activity type
Research Organisations
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL'ABRUZZO E DEL MOLISE G CAPORALE
Italy
EU contribution
€ 393 875
Address
Via Campo Boario
64100 Teramo
Activity type
Research Organisations
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
EU contribution
€ 290 000
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
ENVIRONMENTAL RESEARCH GROUP OXFORD LIMITED
United Kingdom
EU contribution
€ 143 281,25
Address
Ryelands Grove 10
HR6 8QA Leominster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 188 705
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 203 625
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 418 000
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 640 438,75
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
KIMRON VETERINARY INSTITUTE
Israel
EU contribution
€ 87 500
Address
Kimron Street 1
50250 Rishon L'tzion
Activity type
Research Organisations
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 172 625
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
STATENS VETERINAERMEDICINSKA ANSTALT
Sweden
EU contribution
€ 230 000
Address
Ulls Vaeg 2B
75189 Uppsala
Activity type
Research Organisations
KAFKAS UNIVERSITESI
Turkey
EU contribution
€ 110 000
Address
Pasacayiri
36100 Kars
Activity type
Higher or Secondary Education Establishments
INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II
Morocco
EU contribution
€ 137 500
Address
Avenue Allal El Fassi Madinat Al
10101 Rabat
Activity type
Higher or Secondary Education Establishments
THE PIRBRIGHT INSTITUTE LBG
United Kingdom
EU contribution
€ 434 822,50
Address
Ash Road Pirbright
GU24 0NF Woking
Activity type
Research Organisations
International Livestock Research Institute
Kenya
EU contribution
€ 287 851,25
Address
Old Naivasha Rd
00100 Nairobi
Activity type
Research Organisations
INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES
Senegal
EU contribution
€ 129 861,25
Address
Route Des Hydrocarbures Bel Air
3120 Dakar
Activity type
Research Organisations
INSTITUT PASTEUR DE TUNIS
Tunisia
EU contribution
€ 140 000
Address
Place Pasteur 13
1002 Tunis
Activity type
Research Organisations